DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and slc6a11a

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001091857.1	Gene:	slc6a11a / 558960	ZFINID:	ZDB-GENE-030131-3729	Length:	590	Species:	Danio rerio

Alignment Length:	558	Identity:	209/558 - (37%)
Similarity:	318/558 - (56%)	Gaps:	32/558 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEIS 77
            |.|:  .||.|.:|||.:.....:||||:|||||:.::||||.|.|||::.|:..|.|::.||.|
Zfish    18 PEER--GQWANKIEFLLTVAGAIIGLGNVWRFPYLCYKNGGGAFFIPYVLYLVTCGIPLFVLETS 80

  Fly    78 LGQFTGRGVVKAF-DMAPLLKGVA-LGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWE 140
            |||:|.:|.:..: .:.||.:|:. ..|::....||||. .|:|....:..:||..||||:.|..
Zfish    81 LGQYTSQGGIMCWRKVCPLFEGMGYASQLIIVYGSITYI-IIIAWAFLYLFSSFNVELPWASCNN 144

  Fly   141 SWGTD-CHDGNAQNSSGKMSPAQLYFEREIL----HEVPNIDNG---LSLPNWQLVACLAIAWLV 197
            .|.|| |...:.:|||.::: :.|.....::    |.|..:.:|   |....|.|...|.:.|::
Zfish   145 PWNTDTCIVLSGRNSSSELA-SPLNSSSSVMEFWHHRVLRLSSGVEHLGTVRWDLALILLLVWIL 208

  Fly   198 IGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAV 262
            :...:.:|:||:|||.||...||||:|||||||.||||||::||.|:..|....|.:|.||..|.
Zfish   209 VYFCIWKGVKSTGKAVYFTATFPYVMLLILLLRGVTLPGALNGIYYYMYPDLTRLADPQVWMDAG 273

  Fly   263 TQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDI 327
            ||:|:|.|||.|.|.:..|||.:|.|.|.|...:..::|.:|.:.|...|.:||::|:|.| .||
Zfish   274 TQIFYSYAICLGYLSSLGSYNQYNNNCYRDSFYLCLLNSGTSFLGGFAIFSVLGHMAQEQG-VDI 337

  Fly   328 GSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGST-VGMGSCILRVIRDQF---- 387
            ..|.:.|.||.||.||:|:.... :.|.:||.||:|:.:||:.|. ||:.| |:..:.|.|
Zfish   338 SLVAESGPGLVFIVYPQAVTMLP-LSQFWAVCFFIMIILLGLDSQFVGLES-IMTSVTDIFPTVL 400

  Fly   388 --GLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALI-LAIGELVAVAWIYG 449
              |.|..   .|..|:.::.:.:.::.:|.||.:|:.|.|.|..|.|.|: ||..:.||:.|:||
Zfish   401 RRGFRRE---MLLLGICLVCYFMGLLMITEGGLYIIQLFDHYVCSGTTLLFLATCQSVAIGWVYG 462

  Fly   450 VNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKG-VGYPTLAHVFGCFL 513
            .:||.|:|:.|:|.:.....:.||.::||.:.....|:.|:..|.|::.. ..||..|:..|.||
Zfish   463 ADRFYENIQDMIGYKPWPMVKYCWLYVTPSVCVGTFIFSLVKYSPLKFNNKYMYPWWAYGIGWFL 527

  Fly   514 ATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSD 551
            |...|..:|   |..|||.....|:||:|::.||.|::
Zfish   528 AVSSLSLIP---INMIYKLHKGKGTFWERLQLACSPAE 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	184/487 (38%)
slc6a11a	NP_001091857.1	SLC6sbd-TauT-like	21..560	CDD:271387	206/551 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820