DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and slc6a16a

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_021327051.1	Gene:	slc6a16a / 555229	ZFINID:	ZDB-GENE-061009-43	Length:	693	Species:	Danio rerio

Alignment Length:	582	Identity:	179/582 - (30%)
Similarity:	287/582 - (49%)	Gaps:	89/582 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLG 79
            ::||  |.:.|:::.:.:..||||||:|||||:..|||||.|::.|::.||:||.|::::|::.|
Zfish    41 DRPA--WDSKLQYVLAQVGFSVGLGNVWRFPYLCHQNGGGAFMLLYVMLLLIIGVPLFFMELAAG 103

  Fly    80 QFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWG 143
            |...:|.:..: .::|.|.|:.....:.......||:.|:|.:|.:...||...|||.:|    .
Zfish   104 QSIRQGSIGVWKHISPRLAGIGYSSCMVCFFVALYYNVIIAWSLFYMGNSFQYPLPWEQC----P 164

  Fly   144 TDCHDGNAQNSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAWLVIGGVLIRGIKS 208
            .|.............||...::.|:.|....:||..... |..:..||..||.::...:|:||||
Zfish   165 VDMISNQTVKECAASSPTSYFWFRKALDISDSIDQSGEF-NPIMTGCLLAAWAIVCLAMIKGIKS 228

  Fly   209 SGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQ---WRELLNPLVWYAAVTQVFFSLA 270
            |.|..||..||||.||:..|:|.:.|.||||||.|.|.|:   |.|:   .||..|.|||||:|.
Zfish   229 SAKVMYFSSVFPYAVLICFLIRGLMLDGAIDGIKYMFYPKVEIWGEV---QVWRQAATQVFFALG 290

  Fly   271 ICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILG-------------NLAR-- 320
            :.:|::|.|:|||..:.|.:.|.::::.::..:|::|..:.|.:||             |:||
Zfish   291 LGYGSVIAYSSYNPIHNNCHRDAIMVSGINFMTSVLASLVVFVVLGFRAKNIALDCVATNVARMA 355

  Fly   321 ---ETGN----------PDIGSVV-----------------------------KG--GAGLAFIS 341
               :||:          .|..|||                             ||  |.|||||:
Zfish   356 EMAQTGSSQHWRPLFNMSDPKSVVLQDYRQWYSSYGSLLGSNITDCDLEREMSKGVEGTGLAFIA 420

  Fly   342 YPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWKLASGLTVLGF 406
            :.||:|.|...| .::.||||||..||:.:..|....||..:.|.|.:.......|.....:|||
Zfish   421 FTEAMALFPASP-FWSTLFFLMLLNLGLSTMFGTMQGILTPLMDNFRVLGRHKTMLTVCSCILGF 484

  Fly   407 SVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRL 471
            .:.:::....|.:.:.:.|.|..:...:|:.|.|.|:||||||.:||.:|::.|:.......:|.
Zfish   485 LIGLLFTQRSGNYFVTMFDDYSATLPLIIVVIFETVSVAWIYGADRFLDDVEVMLHWRPPVVYRY 549

  Fly   472 CWRFI----TPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAI 529
            .|:::    ..||:.|.|:.|:       :|...|....|..|    :...::.||||:..:
Zfish   550 LWKYVCLLGMVGLLAASLLRMV-------FKRPTYTAWNHTTG----SEASLEYPGWALVVL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	168/536 (31%)
slc6a16a	XP_021327051.1	SLC6sbd-B0AT-like	42..617	CDD:271364	179/581 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820