DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and Slc6a12

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_059031.1	Gene:	Slc6a12 / 50676	RGDID:	620255	Length:	628	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	202/563 - (35%)
Similarity:	313/563 - (55%)	Gaps:	28/563 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGR 69
            |:..:.:|...|...||.|.:||:.|.....:||||:|||||:.::||||.|.|||.|.....|.
  Rat    37 EMMDQKDKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGI 101

  Fly    70 PVYYLEISLGQFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSEL 133
            ||::||::|||::.:|.|.|: .:.|||:|:.:..|:..:....||..|:|..|.:..:||..||
  Rat   102 PVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWEL 166

  Fly   134 PWSRCWESWGTD-CHD-------GNAQNSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVAC 190
            ||:.|..||.|: |.|       ..|..|....||...::||.:|.....|.:..|| .|:|..|
  Rat   167 PWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVLGITSGIHDLGSL-RWELALC 230

  Fly   191 LAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNP 255
            |.:||::....:.:|:||:||..||...|||::|:|||:|.||||||..||:::.||....|.:|
  Rat   231 LLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDP 295

  Fly   256 LVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLAR 320
            .||..|.||:|||.|||.|.|....|||.::.|.|.|.:.:..::|.:|.:||.:.|.|||.:|:
  Rat   296 QVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQ 360

  Fly   321 ETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRD 385
            |.|.| |..|.:.|.|||||::|:|:.... :.|:::.||||||..||:.|......|::....|
  Rat   361 EQGVP-ISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMD 423

  Fly   386 QF-------GLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVS-FTALILAIGELV 442
            .|       |.|.    .|...:.::.:.:.::.:|.||.:|..|.|:|..| ...|.|::.|::
  Rat   424 MFPQQLRKRGRRE----LLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVI 484

  Fly   443 AVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVG-YPTLA 506
            .:.|:||.:||.::::.|:|.......::.|.|:||||..|...:.|...:.|:|..|. ||:..
  Rat   485 CIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYIYPSWG 549

  Fly   507 HVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549
            :..|..||...:..:|.:.|..:.|.:   |||.:|::....|
  Rat   550 YSIGWLLAFSSMACVPLFIIITLLKTQ---GSFKKRLQRLITP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	182/486 (37%)
Slc6a12	NP_059031.1	SLC5-6-like_sbd	49..589	CDD:294310	198/549 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820