DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and SLC6A17

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001010898.1	Gene:	SLC6A17 / 388662	HGNCID:	31399	Length:	727	Species:	Homo sapiens

Alignment Length:	582	Identity:	172/582 - (29%)
Similarity:	289/582 - (49%)	Gaps:	92/582 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLG 79
            ::||  |.:.|:::.:.|..||||||||||||:..:||||.:::|||:.|::||.|:::||:::|
Human    59 DRPA--WNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVG 121

  Fly    80 QFTGRGVVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWG 143
            |...||.:..:. :.|.|.|:.....:.......||:.|:..::.::..||...||||.|
Human   122 QRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC----- 181

  Fly   144 TDCHDGN---AQNSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAWLVIGGVLIRG 205
            ....:|:   .:....|.|....::.||.|....:|.....| ||::..||.:||.::|..:::|
Human   182 PVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGL-NWKMTLCLLVAWSIVGMAVVKG 245

  Fly   206 IKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLA 270
            |:||||..||..:||||||...|:|.:.|.||:|||::.|.|:..::|:|.||..|.|||||:|.
Human   246 IQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALG 310

  Fly   271 ICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILG------------------- 316
            :.||.:|.::|||..:.|.:.|..:::.::..:|::|..:.|.:||
Human   311 LGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKIL 375

  Fly   317 ------NLARETGNPDIG----------------SVVK----------------------GGAGL 337
                  .|:|:...|.:.                ..||                      .|.||
Human   376 GYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGL 440

  Fly   338 AFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWKLASGLT 402
            |||::.||:..|...| .::|:|||||..||:||.:|..:.|...|.|.|.:   |......|..
Human   441 AFIAFTEAMTHFPASP-FWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKV---PKEMFTVGCC 501

  Fly   403 VLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGW 467
            |..|.|.::::...|.:.:.:.|.|..:....::.|.|.:|||||||..:|.:::..|:|.....
Human   502 VFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYR 566

  Fly   468 YWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFL---ATLGLIQLPGWAI 526
            ::...|:|::|      |...:|..:::...||..|.    :..::   |....:..|.||:
Human   567 FYFYMWKFVSP------LCMAVLTTASIIQLGVTPPG----YSAWIKEEAAERYLYFPNWAM 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	162/536 (30%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	172/581 (30%)
SLC6A17	NP_001010898.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820