DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and DAT

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	209/580 - (36%)
Similarity:	300/580 - (51%)	Gaps:	60/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTG 83
            |.|...::||.|.|..:|.|.|:|||||:.::||||.|::||.|.|:|.|.|::|:|::|||...
  Fly    28 ETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNR 92

  Fly    84 RGVVKAFD-MAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGT-DC 146
            :|.:..:. :.||.||:....||.......||:.|:|.:|||:.|||.:.|||:.|...|.| :|
  Fly    93 KGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNC 157

  Fly   147 HDGNAQNSS----------------------------------------GKMSPAQLYFEREILH 171
            ....:||:|                                        |..|.|..||.|.||.
  Fly   158 RPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILE 222

  Fly   172 EVPNIDNG---LSLPNWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVT 233
              .|...|   |....|.:..||.|.:|:....|.:||.:|||..:|..:|||.||||||:|.:|
  Fly   223 --LNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285

  Fly   234 LPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITT 298
            |||:..||.|:..|.:..:....||..|.|||||||...||.|:.|||||.::.|||.|.::.:.
  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350

  Fly   299 MDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLM 363
            ::|.:|.|||.:.|.:||.:|...| ..|..|...|.||.|:.||.|||... ....:|::||:|
  Fly   351 INSATSFIAGFVIFSVLGYMAHTLG-VRIEDVATEGPGLVFVVYPAAIATMP-ASTFWALIFFMM 413

  Fly   364 LFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWK----LASGLTVLGFSVSIVYMTPGGQFILNLV 424
            |..||:.|:.|....|:..:.|:|    |.|.:    ..:||..|.|.|.:...|.||.:..:|:
  Fly   414 LLTLGLDSSFGGSEAIITALSDEF----PKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLL 474

  Fly   425 DFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYML 489
            |.|...::.|:....|.:||:||||.|||.|||:.|:|...|.||::||||:.|..:..:.:|.|
  Fly   475 DRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGL 539

  Fly   490 LDMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549
            :....|.|....||:.|:..|..:|...::.:|.   .||:|.....||..||......|
  Fly   540 IGYEPLTYADYVYPSWANALGWCIAGSSVVMIPA---VAIFKLLSTPGSLRQRFTILTTP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	192/518 (37%)
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	209/580 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850