Protein Alignment List and SLC6A19

DIOPT Version :9

• Sequence 1: NP_611364.2
• Gene: List / 37157
• FlyBaseID: FBgn0034381
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001003841.1
• Gene: SLC6A19 / 340024
• HGNCID: 27960
• Length: 634
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 202/637 - (31%)
• Similarity: 323/637 - (50%)
• Gaps: 119/637 - (18%)

  Fly     1 MTQLEISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALL 65
            :.:|| :.:.|:.:.:|  :|.|..:::.:|:...|||||:|||||:...:|||.|:||:||.|:
Human    18 LAELE-TIEQEEASSRP--KWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLV 79

  Fly    66 VIGRPVYYLEISLGQFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASF 129
            :.|.|:.|||.::||...||.:..: .:.|.|||:.|..:|.:.....||::|::..:.:...||
Human    80 LEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISWIMWYLFNSF 144

  Fly   130 GSELPWSRCWESWGTDCHDGNAQNSSG------KMSPAQLYFEREILHEVPNIDNGLSLPNWQLV 188
            ...||||.|..:          :|.:|      :.||...::.||.|:...:|.:..|: .|.::
Human   145 QEPLPWSDCPLN----------ENQTGYVDECARSSPVDYFWYRETLNISTSISDSGSI-QWWML 198

  Fly   189 ACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELL 253
            .|||.||.|:....||||:::|||.|.....|||||.|.|:|.:||.||.:||::.|.|...||.
Human   199 LCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNVTELA 263

  Fly   254 NPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGIL--- 315
            .|..|..|..|||||.::.||.||:::|||:.:.|...|.||::.::..:|:....:.:.::
Human   264 QPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDSVIVSIINGFTSVYVAIVVYSVIGFR 328

  Fly   316 ------------------------GNLARE----------TGNP-----------DIGSVVK--- 332
                                    ||:.:|          ..:|           ||.:.:.
Human   329 ATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDMQQRCNASDPAAYAQLVFQTCDINAFLSEAV 393

  Fly   333 GGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVG-MGSCI-----LRVIRDQFGLRS 391
            .|.|||||.:.|||.|....| :::||||:|||.||:.|..| |...:     ||||
Human   394 EGTGLAFIVFTEAITKMPLSP-LWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLRVI-------- 449

  Fly   392 PPIW--KLASGLTVLG-FSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRF 453
            ||.|  ::.:||..|| |.:..::....||:.|:|:|.|..|...||:|..|:.:|.::|||:||
Human   450 PPKWPKEVLTGLICLGTFLIGFIFTLNSGQYWLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRF 514

  Fly   454 CEDIKFMMGIETGWYWRLCWRFITPGLMTAV------------LIYMLLDMSALEY---KGVGYP 503
            .:||:||:|.:...:|::.||.::|.||..:            |.|.:.|....|:   :.:.||
Human   515 NKDIEFMIGHKPNIFWQVTWRVVSPLLMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYP 579

  Fly   504 TLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAAC-KPSDTWG 554
            ...:|....:|.:..:.:||:|||.:             ||..| ||.|..|
Human   580 NWVYVVVVIVAGVPSLTIPGYAIYKL-------------IRNHCQKPGDHQG 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	180/548 (33%)
SLC6A19	NP_001003841.1	SLC5-6-like_sbd	32..612	CDD:294310	195/614 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810