DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and slc6a19b

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_956030.1	Gene:	slc6a19b / 326030	ZFINID:	ZDB-GENE-030131-4755	Length:	651	Species:	Danio rerio

Alignment Length:	604	Identity:	194/604 - (32%)
Similarity:	306/604 - (50%)	Gaps:	98/604 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTQLEISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALL 65
            :.:||:.:..::|      :|.|..:::.:|:...|||||:|||||:...:|||.|:||:||.|:
Zfish    22 LERLEVEEAGDRP------KWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLV 80

  Fly    66 VIGRPVYYLEISLGQFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASF 129
            ..|.|:.:||.::||...:|.|..: .:.|.:.||.:..:..:.....||::|:|..:.::..||
Zfish    81 FEGIPLLHLEFAIGQRLRKGSVGVWRTINPYMLGVGIASMCVSFLVSLYYNTIIAWVMWYFFNSF 145

  Fly   130 GSELPWSRCWESWGTDCHDGNAQNSS-----GKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVA 189
            ...||||:|         ..|...:.     ||.||...::.||.|:....||:...|..| :|.
Zfish   146 QDPLPWSQC---------PINENRTGPIPECGKSSPVDYFWYRETLNTSAAIDDTGGLQVW-MVL 200

  Fly   190 CLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLN 254
            ||..||.|:....||||:::|||.|.....||:||.|.|:|.:||.|::|||.:.|.|...||.|
Zfish   201 CLISAWAVLYVCCIRGIETTGKAVYVTSTLPYLVLTIFLIRGLTLKGSVDGIKFLFTPDINELAN 265

  Fly   255 PLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLA 319
            |..|..|..|||:|.::.||.||:::|||:.:.|...|.|||:.:::.:||.|..:.:.|:|..|
Zfish   266 PSTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEQDAVIISVINAFTSIYAATVIYSIIGFRA 330

  Fly   320 RE------TGN-------------------------------PDIGSVVK--------------G 333
            .|      .||                               |||.|.:.              .
Zfish   331 TERFDDCMNGNILTLLNTFDLPEGFINQSNYQDVFQSLNSTSPDIISSLSLKTCDLNNFLSEGVE 395

  Fly   334 GAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIW--K 396
            |.|||||.:.|||.|....| :::||||:|||.||:.|..|....:|..::| .|: .|..|  :
Zfish   396 GTGLAFIVFTEAITKMPLSP-LWSVLFFIMLFCLGLSSMFGNIEGVLVPLQD-LGV-FPKSWPKE 457

  Fly   397 LASGLTVLGFS-VSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFM 460
            :.||:|.|... |.::::...|.:.|.|.|.:..|...||:|..|::.|.::||::||.||:.||
Zfish   458 IISGVTCLVCCLVGLIFVQGSGNYWLALFDSFAGSIPLLIIAFSEMIGVVYVYGIDRFNEDLIFM 522

  Fly   461 MGIETGWYWRLCWRFITPGLMTAVLIYMLL-----------------DMSALEYKGVGYPTLAHV 508
            :|.:...:|:..||||:|.:|.|:.::...                 :...||.|  .|||..:|
Zfish   523 IGHKPNIFWQATWRFISPLIMLAIFVFYFSTTVTKEIFYSAWDPESENFPTLEKK--PYPTWIYV 585

  Fly   509 FGCFLATLGLIQLPGWAIY 527
            ....||.:..:.:||.|::
Zfish   586 IIFLLAGVPSLAVPGTAVF 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	179/529 (34%)
slc6a19b	NP_956030.1	SLC6sbd_B0AT1	33..613	CDD:212085	192/593 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900