DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and Slc6a14

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	212/581 - (36%)
Similarity:	314/581 - (54%)	Gaps:	59/581 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRG 85
            |....::|.|.:..:|||||:|||||:.:.||||.|:|||.|.|.:.|.|:::||.|||||...|
  Rat    45 WSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLG 109

  Fly    86 VVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGTD----- 145
            .|..:.:.||.:||.:..||.:.....||:.|:|.:|.:..|||.|.|||:.|..||..|
  Rat   110 PVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWANCSSSWADDNCSRQ 174

  Fly   146 -----------------------------CHDGNAQNSSGKMSPAQLYFEREILHEVPNID-NGL 180
                                         |.:|:.....|:: |::.|:::..|.....:| .|:
  Rat   175 PIVTGCRVSTDTGGDMFMNISWVNSNNFTCLNGSEVFRPGQL-PSEQYWDKVTLRRSSGMDETGV 238

  Fly   181 SLPNWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFF 245
            .:  |.|..||.:||:::|..|.:|||||||..||..:||||||||||:|..||.||..||.|:.
  Rat   239 IV--WYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGATLEGASKGISYYI 301

  Fly   246 KPQ--WRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAG 308
            ..|  :.:|....||..|.||:|:||::.:|.|:..:|||.||.|.|:|.:|:...:..:|:.||
  Rat   302 GAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAIIVCLTNCLTSVFAG 366

  Fly   309 CITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTV 373
            ...|.|||::|..:|. ::..|||.|..||||:||||:|:....| .:::|||.||..||:.|..
  Rat   367 FAIFSILGHMAHISGK-EVSQVVKSGFDLAFIAYPEALAQLPGGP-FWSILFFFMLLTLGLDSQF 429

  Fly   374 GMGSCILRVIRDQF-----GLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTA 433
            .....|...|:|.|     .:|.|    :..|..::.|.:.:|.:|..|.:.::|:|.:...:..
  Rat   430 ASIETITTTIQDLFPKAMKRMRVP----ITLGCCLILFLLGLVCVTQAGIYWVHLIDHFCAGWGI 490

  Fly   434 LILAIGELVAVAWIYGVNRFCEDIKFMMGIETGW----YWRLCWRFITPGLMTAVLIYMLLDMSA 494
            ||.||.|:..:.||||.|||.|||:.|:|.:. |    :||.||..|||.|::|:|::.|:....
  Rat   491 LIAAILEIAGIIWIYGGNRFIEDIEMMIGAKR-WLFWLWWRACWFVITPILLSAILVWSLVKFHR 554

  Fly   495 LEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWGP 555
            ..|..:.||......|..:....:|.:|   |.||.|.....|:..|||...|:|:..|||
  Rat   555 PNYADIPYPDWGVALGWCMIIFCIIWIP---IMAIIKIVRAEGNILQRIIKCCRPASNWGP 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	192/513 (37%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	212/581 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920