DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and Slc6a4

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_037166.2	Gene:	Slc6a4 / 25553	RGDID:	3714	Length:	630	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	196/548 - (35%)
Similarity:	306/548 - (55%)	Gaps:	30/548 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTG 83
            |.||..::||.|.|..:|.||||||||||.:|||||.|::||.|..:..|.|::|:|::|||:..
  Rat    80 ETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHR 144

  Fly    84 RGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGT-DC 146
            .|.:..: .:.|:.||:.....:......:||::|:|..|.:.::|....|||:.|..||.| :|
  Rat   145 NGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNC 209

  Fly   147 HDGNAQN----SSGKMSPAQLYFEREIL--HEVPNIDNGLSLPNWQLVACLAIAWLVIGGVLIRG 205
            .:..||:    :....|||:.::.|.:|  |:...:.: |...:|||..|:.:.:.||...:.:|
  Rat   210 TNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQD-LGTISWQLTLCIVLIFTVIYFSIWKG 273

  Fly   206 IKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLA 270
            :|:|||..:....|||:||.:||:|..|||||..|::::.||.|::||...||..|..|:||||.
  Rat   274 VKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLG 338

  Fly   271 ICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVK-GG 334
            ..||.|:.:||||.||.|.|.|.::.:.::..:|.::|.:.|.:||.:| |..|.|:..|.| .|
  Rat   339 PGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMA-EMRNEDVSEVAKDAG 402

  Fly   335 AGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWK--- 396
            ..|.||:|.||||... ....||::|||||..||:.||......::..:.|:|    |.||.
  Rat   403 PSLLFITYAEAIANMP-ASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEF----PHIWAKRR 462

  Fly   397 ----LASGLT-VLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCED 456
                |...:| |||   |::.:|.||.:::.|::.|......|.:|:.|.|||:|.||:.:||.|
  Rat   463 EWFVLIVVITCVLG---SLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSD 524

  Fly   457 IKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQL 521
            :|.|:|...||:||:||..|:|..:..::...|:....|......||..:.|.|..:....:|.:
  Rat   525 VKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICI 589

  Fly   522 PGWAIYAIYKKRGHNGSFWQRIRAACKP 549
            |   .|.||:.....|:..:||..:..|
  Rat   590 P---TYIIYRLISTPGTLKERIIKSITP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	181/486 (37%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..60
		5HT_transport_N	24..64	CDD:397524
		SLC6sbd_SERT	79..615	CDD:271399	196/548 (36%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920