DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and Slc6a11

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_766478.1	Gene:	Slc6a11 / 243616	MGIID:	95630	Length:	627	Species:	Mus musculus

Alignment Length:	534	Identity:	191/534 - (35%)
Similarity:	294/534 - (55%)	Gaps:	28/534 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRG 85
            |.|.:||:.|.....:||||:|||||:.::||||.|:|||::..:..|.||::||.:|||||..|
Mouse    48 WNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEG 112

  Fly    86 VVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLAS-FGSELPWSRCWESWGTD-CH 147
            .:..: .:.||.:|:.....:..|....||..|:|..: |:|:: |.:||||:.|...|.|: |.
Mouse   113 GITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAI-FYLSNCFTTELPWATCGHEWNTEKCV 176

  Fly   148 DGNAQNSS--------GKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVACLAIAWLVIGGVLIR 204
            :....|.|        ...||...::||.:|.....|::..:| .|:|..||..||.:....:.:
Mouse   177 EFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNL-RWELALCLLAAWTICYFCIWK 240

  Fly   205 GIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSL 269
            |.||:||..|....|||::|||||:|.||||||.:||.::..|....|.:|.||..|.||:|||.
Mouse   241 GTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSY 305

  Fly   270 AICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGG 334
            |||.|.|....||||:|.|.|.|.:::..::|.:|.:||...|.:||.:|.|.|.| |..|.:.|
Mouse   306 AICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVP-IAEVAESG 369

  Fly   335 AGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWK--- 396
            .|||||:||:|:......| ::|.|||:||..||:.|.......::..:.|.:    |.:::
Mouse   370 PGLAFIAYPKAVTMMPLSP-LWATLFFMMLIFLGLDSQFVCVESLVTAVVDMY----PKVFRRGY 429

  Fly   397 ----LASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVS-FTALILAIGELVAVAWIYGVNRFCED 456
                |...|:::.:.:.:|.:|.||.:|..|.|.|..| ...|.:||.|.|.:.|:||.|||.::
Mouse   430 RRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDN 494

  Fly   457 IKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGV-GYPTLAHVFGCFLATLGLIQ 520
            |:.|:|.......:.||:.:|||:...:.|:.|:....|:|..| .||...:..|..:|...::.
Mouse   495 IEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLC 559

  Fly   521 LPGWAIYAIYKKRG 534
            :|.|....::|..|
Mouse   560 IPLWIFIKLWKTEG 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	179/486 (37%)
Slc6a11	NP_766478.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
Slc6a11	NP_766478.1	SLC6sbd_GAT3	44..585	CDD:212077	191/534 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820