DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and Slc6a7

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_006525992.1	Gene:	Slc6a7 / 240332	MGIID:	2147363	Length:	684	Species:	Mus musculus

Alignment Length:	586	Identity:	214/586 - (36%)
Similarity:	327/586 - (55%)	Gaps:	41/586 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EISKKSEKPAE-----KPAEQ---------------WGNGLEFLFSCISLSVGLGNIWRFPYIAF 49
            |..|::.||..     .|::|               |...|:||.|||...|||||:|||||.|:
Mouse    51 EFQKQAGKPITPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAY 115

  Fly    50 QNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYY 114
            .||||.|::||.:.|.:.|.|:::||:|||||:..|.:..:.::||.||.....:|.......||
Mouse   116 TNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYY 180

  Fly   115 SSIMALTLRFWLASFGSELPWSRCWESWGTD-C------HDGNA---QNSSGKMSPAQLYFEREI 169
            :.|:|..|.:..||..|.|||..|...|.|: |      ..||.   .|.|..:||::.|:.|.:
Mouse   181 NMIIAYVLFYLFASLTSNLPWEHCGNWWNTELCLEHRGPKSGNGVLPLNLSSTVSPSEEYWSRYV 245

  Fly   170 LHEVPNIDNGLSLP---NWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRA 231
            ||...:  .|:..|   .|.|..||.:||:::...:::|:|||||..||...|||::||:||:|.
Mouse   246 LHIQGS--QGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRG 308

  Fly   232 VTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVII 296
            ||||||..||.::..||:..||:..||..|..|:|:||.:.||.|:|:||||.|::|:|.|..|:
Mouse   309 VTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIV 373

  Fly   297 TTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFF 361
            |..::.:||:||...|.:||.:::|.|.| :..|.|.|.||||:.||:|:......| .::.|||
Mouse   374 TLGNAITSILAGFAIFSVLGYMSQELGVP-VDQVAKAGPGLAFVVYPQAMTMLPLSP-FWSFLFF 436

  Fly   362 LMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWKLASGL-TVLGFSVSIVYMTPGGQFILNLVD 425
            .||..||:.|.......|:..:.|:|.....|...:.||| .|..:.:.::..|.||.:.|.|:|
Mouse   437 FMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLD 501

  Fly   426 FYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLL 490
            .|..||..:::.|...:||..:||:.|||.||..|:|.:.|.|:|.||.|::|..:.|:|:|.::
Mouse   502 DYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIV 566

  Fly   491 DMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWGP 555
            .....||....:|..|.:.|..:..|..:.:|...:.|:.::   .||.|:|::.|.:|:..|||
Mouse   567 KYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLRE---EGSLWERLQQASRPAMDWGP 628

  Fly   556 A 556
            :
Mouse   629 S 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	192/498 (39%)
Slc6a7	XP_006525992.1	SLC5-6-like_sbd	84..628	CDD:382020	206/550 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3662
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870