DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and Slc6a13

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_006237280.2	Gene:	Slc6a13 / 171163	RGDID:	620788	Length:	608	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	198/569 - (34%)
Similarity:	310/569 - (54%)	Gaps:	33/569 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRP 70
            :.:|.|:......|||.|.:||:.|.....:||||:|||||:.::||||.|.|||||.|...|.|
  Rat    20 VMEKVEEDGTLEREQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIP 84

  Fly    71 VYYLEISLGQFTGRGVVKAF-DMAPLLK------GVALGQVLATAASITYYSSIMALTLRFWLAS 128
            |::||.:|||:|.:|.:.|: .:.|:.:      |:.....:..:....||..::|..|.:..:|
  Rat    85 VFFLETALGQYTNQGGITAWRKICPIFEASVPSPGIGYASQMIVSLLNVYYIVVLAWALFYLFSS 149

  Fly   129 FGSELPWSRCWESWGTD-CHDGNAQNSS------GKMSPAQLYFEREILHEVPNIDNGLSLPNWQ 186
            |.::|||..|...|.|: |.:....|:|      ...||...::||.:|.....|.:..|| .|:
  Rat   150 FTTDLPWGSCSHEWNTENCVEFQKTNNSLNVTSENATSPVIEFWERRVLKISDGIQHLGSL-RWE 213

  Fly   187 LVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRE 251
            ||.||.:||::....:.:|:||:||..||...|||::|::||:|.||||||..||.::..|....
  Rat   214 LVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITR 278

  Fly   252 LLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILG 316
            |.:|.||..|.||:|||.|||.|.|....|||.::.|.|.|.|.:..::|.:|.:||...|.|||
  Rat   279 LWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCVALCILNSSTSFVAGFAIFSILG 343

  Fly   317 NLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILR 381
            .:::|.|.| |..|.:.|.|||||:||.|:....:.| ::|..||.|:.:||:.|.......::.
  Rat   344 FMSQEQGVP-ISEVAESGPGLAFIAYPRAVVMLPFSP-LWACCFFFMVVLLGLDSQFVCVESLVT 406

  Fly   382 VIRDQFGLRSPPIWK-------LASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVS-FTALILAI 438
            .:.|.:    |.:::       |...::|:.|.:.::.:|.||.::..|.|:|..| ...|.:||
  Rat   407 ALVDMY----PRVFRKKNRREILILIVSVVSFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAI 467

  Fly   439 GELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEY-KGVGY 502
            .|.:.|||:||.:||.::|:.|:|.:.....:.||.|.||.:..|..::.|:..:.|.| |...|
  Rat   468 FESLCVAWVYGASRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTY 532

  Fly   503 PTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSD 551
            |......|..||...::.:|.|   :|||.|...|...:|:|....|::
  Rat   533 PWWGDALGWLLALSSMVCIPAW---SIYKLRTLKGPLRERLRQLVCPAE 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	177/491 (36%)
Slc6a13	XP_006237280.2	SLC5-6-like_sbd	32..581	CDD:382020	196/557 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820