DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and Slc6a5

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_976079.1	Gene:	Slc6a5 / 171148	RGDID:	621824	Length:	799	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	215/593 - (36%)
Similarity:	324/593 - (54%)	Gaps:	54/593 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRP 70
            |.:..:....|....|.:.|:|:.|.:..:|||||:|||||:|||||||.|:||||:.|.:.|.|
  Rat   181 IPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLP 245

  Fly    71 VYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPW 135
            :::||:|||||..:|.|..:...|.|:|..:..::.:.....||:.|:..||.:..|||.|.|||
  Rat   246 IFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPW 310

  Fly   136 SRCWESWGT-DCHDG----------------------------------NAQNSSGK--MSPAQL 163
            ..|...|.| :|.|.                                  |..:.:.|  :|.::.
  Rat   311 GSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEE 375

  Fly   164 YFEREILHEVPNIDNGLSLP---NWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLL 225
            ||:..:|    .|..|:..|   .|.|..||.:||:::...|.:|||:|||..||...||||||:
  Rat   376 YFKYFVL----KISAGIEYPGEIRWPLPFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLV 436

  Fly   226 ILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVY 290
            |||:|.||||||..||.||..|:|.:|.:..||..|.||:||||:..:|.|||.:|||.|:.|.|
  Rat   437 ILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCY 501

  Fly   291 NDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQM 355
            .|.:|:|..:|.:||.||.:.|.::|.:|.|. ..:|.:|...|.|:||:.||||:.:....| .
  Rat   502 RDTLIVTCTNSATSIFAGFVIFSVIGFMANER-KVNIENVADQGPGIAFVVYPEALTRLPLSP-F 564

  Fly   356 FAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFG--LRS-PPIWKLASGLTVLGFSVSIVYMTPGG 417
            :|::|||||..||:.:.......|:..|.|:|.  ||: .|::.|  |..:..|.:....:|.||
  Rat   565 WAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTL--GCCICFFIMGFPMITQGG 627

  Fly   418 QFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMT 482
            .::..|||.|..|:..:|:||.|||.::::||:.||||||:.|:|.:...:|::||.|:||.::|
  Rat   628 IYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILT 692

  Fly   483 AVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAAC 547
            .:|.:.......:.|....||..:.|.|..:....:|.:|...:..:|...|.   |.:|::..|
  Rat   693 FILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGR---FIERLKLVC 754

  Fly   548 KPSDTWGP 555
            .|...|||
  Rat   755 SPQPDWGP 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	197/512 (38%)
Slc6a5	NP_976079.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
Slc6a5	NP_976079.1	SLC6sbd_GlyT2	193..789	CDD:271389	213/581 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920