DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and Slc6a12

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001368835.1	Gene:	Slc6a12 / 14411	MGIID:	95628	Length:	628	Species:	Mus musculus

Alignment Length:	563	Identity:	202/563 - (35%)
Similarity:	312/563 - (55%)	Gaps:	28/563 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGR 69
            |:..:..|...|...||.|.:||:.|.....:||||:|||||:.::||||.|.|||.|.....|.
Mouse    37 EMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGI 101

  Fly    70 PVYYLEISLGQFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSEL 133
            ||::||::|||::.:|.|.|: .:.|||:|:.:..|:..:....||..|:|..|.:..:||..||
Mouse   102 PVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWEL 166

  Fly   134 PWSRCWESWGTD-CHD-------GNAQNSSGKMSPAQLYFEREILHEVPNIDNGLSLPNWQLVAC 190
            ||:.|..||.|: |.|       ....:|....||...::||.:|.....|.:..|| .|:|..|
Mouse   167 PWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWERRVLGITSGIHDLGSL-RWELALC 230

  Fly   191 LAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNP 255
            |.:||::....:.:|:||:||..||...|||::|:|||:|.||||||..||:::.||....|.:|
Mouse   231 LLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDP 295

  Fly   256 LVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLAR 320
            .||..|.||:|||.|||.|.|....|||.::.|.|.|.:.:..::|.:|.:||.:.|.|||.:::
Mouse   296 QVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQ 360

  Fly   321 ETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRD 385
            |.|.| |..|.:.|.|||||::|:|:.... :.|:::.|||:||..||:.|......|::....|
Mouse   361 EQGIP-ISEVAESGPGLAFIAFPKAVTMMP-LSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMD 423

  Fly   386 QF-------GLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVS-FTALILAIGELV 442
            .|       |.|.    .|...::||.:.:.::.:|.||.:|..|.|:|..| ...|.|::.|::
Mouse   424 MFPQQLRKSGRRE----LLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVI 484

  Fly   443 AVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGV-GYPTLA 506
            .:.|:||.:||.::::.|:|.......::.|.|:||||..|...:.|...:.|:|..| .||:..
Mouse   485 CIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWG 549

  Fly   507 HVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549
            :..|..||...:..:|.:.|....|.:   |||.:|:|....|
Mouse   550 YSIGWLLAFSSMACVPLFIIITFLKTQ---GSFKKRLRRLITP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	181/486 (37%)
Slc6a12	NP_001368835.1	SLC5-6-like_sbd	49..589	CDD:382020	198/549 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820