Protein Alignment List and Slc6a3

DIOPT Version :9

• Sequence 1: NP_611364.2
• Gene: List / 37157
• FlyBaseID: FBgn0034381
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Alignment Length: 563
• Identity: 205/563 - (36%)
• Similarity: 313/563 - (55%)
• Gaps: 22/563 - (3%)

  Fly     1 MTQLEISKKSEKPAE-KPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIAL 64
            :|...:....:.|.| :..|.|...::||.|.|..:|.|.|:|||||:.::||||.|::|||:.:
Mouse    42 LTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFM 106

  Fly    65 LVIGRPVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASF 129
            ::.|.|::|:|::||||...|....:.:.|:||||....:|.:.....:|:.|:|..|.::.:||
Mouse   107 VIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSF 171

  Fly   130 GSELPWSRCWESWGT-DCHDGNAQNSSGKM--------SPAQLYFEREI--LHEVPNIDNGLSLP 183
            ..:|||..|..:|.: :|.|.::.|||..:        :||..||||.:  ||:...||: |..|
Mouse   172 TMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDD-LGPP 235

  Fly   184 NWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQ 248
            .|||.|||.:..:::...|.:|:|:|||..:.....|||||..||||.||||||:|||..:....
Mouse   236 RWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD 300

  Fly   249 WRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFG 313
            :..|....||..|.|||.|||.:.||.||.::|||.|..|.|.|.:|.|:::|.:|..:|.:.|.
Mouse   301 FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFS 365

  Fly   314 ILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSC 378
            .||.:|::...| |..|...|.||.||.||||||... :...:|.:|||||..|||.|.:|....
Mouse   366 FLGYMAQKHNVP-IRDVATDGPGLIFIIYPEAIATLP-LSSAWAAVFFLMLLTLGIDSAMGGMES 428

  Fly   379 ILRVIRDQFGL--RSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGEL 441
            ::..:.|:|.|  |...::.|  |:.:..|.:|:..:|.||.::..|:|.:....:.|...:.|.
Mouse   429 VITGLVDEFQLLHRHRELFTL--GIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEA 491

  Fly   442 VAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLA 506
            :.|||.|||.:|.:|||.|.|.....||||||:.::|..:..|::..::......|....:|..|
Mouse   492 IGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWA 556

  Fly   507 HVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKP 549
            :..|..:||..:..:|   |||.||.....|||.:::..|..|
Mouse   557 NALGWIIATSSMAMVP---IYATYKFCSLPGSFREKLAYAITP 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	185/482 (38%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:294310	202/545 (37%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		12/31 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820