DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and Slc6a7

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	209/550 - (38%)
Similarity:	318/550 - (57%)	Gaps:	21/550 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRG 85
            |...|:||.|||...|||||:|||||.|:.||||.|::||.:.|.:.|.|:::||:|||||:..|
  Rat    40 WTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLG 104

  Fly    86 VVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCWESWGTD-C--- 146
            .:..:.::||.||.....:|.......||:.|:|..|.:..||..|.|||..|...|.|: |
  Rat   105 PLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSNLPWEHCGNWWNTERCLEH 169

  Fly   147 ---HDGNAQ---NSSGKMSPAQLYFEREILHEVPNIDNGLSLP---NWQLVACLAIAWLVIGGVL 202
               .|||..   |.|..:||::.|:.|.:||...:  .|:..|   .|.|..||.:||:::...:
  Rat   170 RGPKDGNGALPLNLSSTVSPSEEYWSRYVLHIQGS--QGIGRPGEIRWNLCLCLLLAWVIVFLCI 232

  Fly   203 IRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFF 267
            ::|:|||||..||...|||::||:||:|.||||||..||.::..||:..||:..||..|..|:|:
  Rat   233 LKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFY 297

  Fly   268 SLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVK 332
            ||.:.||.|:|:||||.|::|:|.|..|:|..::.:||:||...|.:||.:::|.|.| :..|.|
  Rat   298 SLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVP-VDQVAK 361

  Fly   333 GGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFGLRSPPIWKL 397
            .|.||||:.||:|:......| .::.|||.||..||:.|.......|:..:.|:|.....|...:
  Rat   362 AGPGLAFVVYPQAMTMLPLSP-FWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAV 425

  Fly   398 ASGL-TVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMM 461
            .||| .|..:.:.::..|.||.:.|.|:|.|..||..:::.|...:||..:||:.|||.||..|:
  Rat   426 FSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMML 490

  Fly   462 GIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAI 526
            |.:.|.|:|.||.|::|..:.|:|:|.::.....||....:|..|.:.|..:..|..:.:|...:
  Rat   491 GFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGML 555

  Fly   527 YAIYKKRGHNGSFWQRIRAACKPSDTWGPA 556
            .|:.::   .||.|:|::.|.:|:..|||:
  Rat   556 VAVLRE---EGSLWERLQQASRPAIDWGPS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	192/481 (40%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	207/547 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920