DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and Slc6a5

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_006540608.1	Gene:	Slc6a5 / 104245	MGIID:	105090	Length:	831	Species:	Mus musculus

Alignment Length:	593	Identity:	215/593 - (36%)
Similarity:	323/593 - (54%)	Gaps:	54/593 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRP 70
            |.:..:....|....|.:.|:|:.|.:..:|||||:|||||:|||||||.|:||||:.|.:.|.|
Mouse   213 IPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLP 277

  Fly    71 VYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPW 135
            :::||:|||||..:|.|..:...|.|:|..:..::.:.....||:.|:..||.:..|||.|.|||
Mouse   278 IFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPW 342

  Fly   136 SRCWESWGT-DCHDG------------------------------------NAQNSSGKMSPAQL 163
            ..|...|.| :|.|.                                    .:|.:...:|.::.
Mouse   343 GSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQTNKTFVSGSEE 407

  Fly   164 YFEREILHEVPNIDNGLSLP---NWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLL 225
            ||:..:|    .|..|:..|   .|.|..||.:||:::...|.:|||||||..||...||||||:
Mouse   408 YFKYFVL----KISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKSSGKVVYFTATFPYVVLV 468

  Fly   226 ILLLRAVTLPGAIDGIIYFFKPQWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVY 290
            |||:|.||||||..||.||..|:|.:|.:..||..|.||:||||:..:|.|||.:|||.|:.|.|
Mouse   469 ILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCY 533

  Fly   291 NDIVIITTMDSCSSIIAGCITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQM 355
            .|.:|:|..:|.:||.||.:.|.::|.:|.|. ..:|.:|...|.|:||:.||||:.:....| .
Mouse   534 RDTLIVTCTNSATSIFAGFVIFSVIGFMANER-KVNIENVADQGPGIAFVVYPEALTRLPLSP-F 596

  Fly   356 FAVLFFLMLFVLGIGSTVGMGSCILRVIRDQFG--LRS-PPIWKLASGLTVLGFSVSIVYMTPGG 417
            :|::|||||..||:.:.......|:..|.|:|.  ||: .|::.|  |..:..|.:....:|.||
Mouse   597 WAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTL--GCCICFFIMGFPMITQGG 659

  Fly   418 QFILNLVDFYGVSFTALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMT 482
            .::..|||.|..|:..:|:||.|||.::::||:.||||||:.|:|.:...:|::||.|:||.::|
Mouse   660 IYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIFWKVCWAFVTPTILT 724

  Fly   483 AVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAAC 547
            .:|.:.......:.|....||..:.|.|..:....:|.:|...:..:|...|.   |.:|::..|
Mouse   725 FILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGR---FIERLKLVC 786

  Fly   548 KPSDTWGP 555
            .|...|||
Mouse   787 SPQPDWGP 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	197/512 (38%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	213/581 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020