DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment List and slc6a4

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_017946918.1	Gene:	slc6a4 / 100493853	XenbaseID:	XB-GENE-22062972	Length:	664	Species:	Xenopus tropicalis

Alignment Length:	553	Identity:	191/553 - (34%)
Similarity:	298/553 - (53%)	Gaps:	44/553 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QLEISKKSEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVI 67
            |.||.::         |.|...::||.|.|..:|.|||:|||||:.:|||||.|:|||:|..:..
Frog   107 QTEIGER---------ETWSKKIDFLLSVIGYAVDLGNVWRFPYVCYQNGGGAFLIPYVIMAVFG 162

  Fly    68 GRPVYYLEISLGQFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGS 131
            |.|::|:|:::||:...|.:..: .:.||.||:.....:.......||::|||..|.:.:.||.|
Frog   163 GIPLFYMELAMGQYHRNGCISIWRKICPLFKGIGYAICMIALYVAFYYNTIMAWALYYLIFSFRS 227

  Fly   132 ELPWSRCWESWGTDCHDGNAQN---------SSGKMSPAQLYFEREIL--HEVPNIDN--GLSLP 183
            ||||:.|...|.|    ||..|         |:..:|||:.::.|.:|  |:...:.:  |:|
Frog   228 ELPWTSCLNEWNT----GNCTNYFQNSSVGWSNSSISPAEEFYTRLVLQIHKSKGLHDLGGIS-- 286

  Fly   184 NWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQ 248
             |||..||.:.:.|:...:.:|:|:|||..:....|||:||.:||:|..|||||..|::::.:|.
Frog   287 -WQLTLCLLLIFTVVYFSIWKGVKTSGKVVWVTATFPYIVLALLLIRGATLPGAWRGVLFYLQPD 350

  Fly   249 WRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFG 313
            |.:||...||..|..|:||||...||.|:.:||||.|:.|.|.|.:|.:|::..:|.::|.:.|.
Frog   351 WEKLLTTAVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNNCYQDALITSTVNCMTSFMSGLVIFT 415

  Fly   314 ILGNLARETGNPDIGSVVKG-GAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGS 377
            :||.:| |..|.|:..|.|. |..|.||:|.||||... ....||::|||||..||:.||.....
Frog   416 VLGYMA-EMRNLDVSEVAKDTGPSLLFITYAEAIANMP-ASTFFAIIFFLMLITLGLDSTFAGLE 478

  Fly   378 CILRVIRDQFGLRSPPIWKLASGLTVLGFSVSIVY------MTPGGQFILNLVDFYGVSFTALIL 436
            .::..:.|:|    |.||.....|.|. ..:|:.:      :|.||.:::.|.:.|......|.:
Frog   479 GVITAVLDEF----PHIWGKRRELFVF-LLISVCFLGALSTLTFGGAYMVKLFEEYATGPAVLTV 538

  Fly   437 AIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVG 501
            ...|.:||:|.||:|:||.|::.|:|...||:|::||..|.|..:..::...:.....|......
Frog   539 VFLEAIAVSWFYGINQFCRDVREMLGFSPGWFWKICWVAICPLFLLFIICSFMSSPPDLRLFNYQ 603

  Fly   502 YPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRG 534
            ||:...|.|..:.|...|.:|.:.:|.:....|
Frog   604 YPSWTVVLGYCIGTSSFICVPAYMVYLLTSTPG 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	178/490 (36%)
slc6a4	XP_017946918.1	5HT_transport_N	48..91	CDD:367522
slc6a4	XP_017946918.1	SLC5-6-like_sbd	113..649	CDD:382020	188/547 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010