DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and slc6a13

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_002667408.5	Gene:	slc6a13 / 100332592	ZFINID:	ZDB-GENE-170607-2	Length:	621	Species:	Danio rerio

Alignment Length:	575	Identity:	206/575 - (35%)
Similarity:	307/575 - (53%)	Gaps:	37/575 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QLEISKKSEKPAE---------KPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVI 58
            ::|.|....:|.|         |...||.|.|||:.|.....:||||:|||||:.::||||.|.|
Zfish     6 EMEPSNGLNRPLEIVPHAEVKMKDRGQWSNKLEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFI 70

  Fly    59 PYLIALLVIGRPVYYLEISLGQFTGRGVVKAF-DMAPLLKGVALGQVLATAASITYYSSIMALTL 122
            ||||.|...|.||::|||||||:|..|.:..: .::||.:|:.....:..|....||..::|..:
Zfish    71 PYLIFLFTCGIPVFFLEISLGQYTSEGGITCWRKISPLFEGIGYATQVIVALLNFYYIIVLAWGI 135

  Fly   123 RFWLASFGSELPWSRCWESWGTD-CHDGNAQNSS-------GKMSPAQLYFEREILHEVPNIDNG 179
            .:...||...||||.|..:|.|: |.:...:|.|       ...||...::||.:|.....|::
Zfish   136 FYLSNSFTWNLPWSSCNNTWNTESCMEFQRRNDSVDQSYLDNATSPVIEFWERRVLRISSGIED- 199

  Fly   180 LSLPNWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYF 244
            :...:|.||.||.:||::....:.:|:||:||..||...||||:|||||:|.||||||..||.::
Zfish   200 IGTLHWDLVLCLLLAWVLCYFCIWKGVKSTGKVVYFTATFPYVMLLILLIRGVTLPGASRGIQFY 264

  Fly   245 FKPQWRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGC 309
            ..|....|.:|.||..|.||:|||.|||.|.|....|||.:|.|.|.|.:.:..::|.:|.:||.
Zfish   265 LYPDLGRLADPQVWMDAGTQIFFSYAICLGCLTALGSYNKYNNNCYRDSLALCFLNSGTSFVAGF 329

  Fly   310 ITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVG 374
            ..|.|||.::.|...| |..|.:.|.|||||:||.|::.....| ::|..||:|:.:||:.|...
Zfish   330 AIFSILGFMSYEQNVP-ISEVAESGPGLAFIAYPRAVSMMPISP-LWACFFFIMIVLLGLDSQFV 392

  Fly   375 MGSCILRVIRDQFGLRSPPIWK-------LASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVS-F 431
            ....::..:.|.:    |..::       |...:.::.|.|.::.:|.||.::..|.|:|..| .
Zfish   393 CVESLVTAMVDMY----PSFFRRKNRRELLILVVAIVSFLVGLIMLTEGGMYVFQLFDYYAASGM 453

  Fly   432 TALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALE 496
            ..|.:||.|.|.:|||||.|||.::|:.|:|...|.|.:.||.|.||........:.|:..:.|:
Zfish   454 CLLFVAIFETVCIAWIYGANRFYDNIEDMIGYRPGPYIKYCWLFFTPATCFGTFAFSLIKYTPLK 518

  Fly   497 YKG-VGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPS 550
            |.. ..||...:..|..||...:|.:|.|.||.:...:   ||..:|::...:||
Zfish   519 YNNEYVYPWWGYALGWMLALSSMICVPLWVIYRMGTTK---GSLMERVQFLIRPS 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	183/486 (38%)
slc6a13	XP_002667408.5	SLC6sbd-TauT-like	30..569	CDD:271387	199/548 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820