DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment List and slc6a14

DIOPT Version :9

Sequence 1:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001313379.1	Gene:	slc6a14 / 100150665	ZFINID:	ZDB-GENE-130411-2	Length:	614	Species:	Danio rerio

Alignment Length:	573	Identity:	199/573 - (34%)
Similarity:	320/573 - (55%)	Gaps:	41/573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KSEKPAEKPAE--------QWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALL 65
            ||:| ||...:        .|.:..|::.|.|..:|||||:|||||:|:::|||.|:|||.|.|.
Zfish    26 KSDK-AEHVVQNDENSDRGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYKHGGGAFLIPYTIMLA 89

  Fly    66 VIGRPVYYLEISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFG 130
            |.|.|::::|.|.|||..:|.:..:...|:|:||.:..:|.:.....||:.|:|.::.:..|||.
Zfish    90 VSGLPLFFMESSFGQFCSQGPINVWKAVPILQGVGITMMLVSTFVAIYYNVIIAYSIYYLFASFQ 154

  Fly   131 SELPWS--RCWESWGTDCHDGNAQNSSGKMSPAQL---YFEREILHEVPNIDNGLSLPNWQLVAC 190
            ..||||  .| .:..::........|.|::|...|   |::...|....::|....:. |.|..|
Zfish   155 DPLPWSIKNC-NTTASNISTAAVNVSCGQISGQSLSEKYWDEVALQRSSSMDETGPVV-WHLALC 217

  Fly   191 LAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQ--WRELL 253
            |.::|:::|..|.:|||||||..||...|||:||||||:|..||.||.|||.::...|  ..:|.
Zfish   218 LLLSWILVGAALFKGIKSSGKVVYFTATFPYIVLLILLIRGATLEGAKDGIEFYIGSQSNLTKLA 282

  Fly   254 NPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNL 318
            ...||..|.||:||||:|.:|.|:..:|||.|..|.|.|.:::...:..:||.||...|.:||::
Zfish   283 EAEVWKDAATQIFFSLSIAWGGLMALSSYNKFYNNCYQDSIVVCVTNCGTSIFAGFAIFSVLGHM 347

  Fly   319 ARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVG----MGSCI 379
            |.....| :..|...|..||||:||:|::|....| ::::|||.||..||:.|...    :.:|:
Zfish   348 AHVYQRP-VSEVADAGFALAFIAYPDALSKLPISP-LWSILFFFMLITLGLDSQFAGIEVISTCL 410

  Fly   380 L----RVIRDQFGLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGE 440
            |    .|::.:.||       :.:.:.::.|.:.:..:|..|.:.:||:|.:...:..|:..:.|
Zfish   411 LDAYPEVLKSKRGL-------VTTAVCIILFLLGLPCVTRAGIYWVNLIDTFSAGWILLVAGLLE 468

  Fly   441 LVAVAWIYGVNRFCEDIKFMMGIETG--W-YWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGY 502
            ::.:..:||.|||.:||:.|:|.::.  | :||.||.||||.:::.:||:.|...::..|..|.|
Zfish   469 VLGLCILYGGNRFIKDIEMMIGTKSSLFWLWWRACWFFITPVVLSIILIWSLYTFTSPTYSSVAY 533

  Fly   503 PTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWGP 555
            |......|..:....|:.:|..|::.:.|.|   |..||||::||.|::.|||
Zfish   534 PDWGISLGWCITAFSLMWIPIVAVWKVCKAR---GGLWQRIKSACSPTEDWGP 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	172/495 (35%)
slc6a14	NP_001313379.1	SLC6sbd_ATB0	42..612	CDD:271391	194/556 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920