Protein Alignment Vps51 and VPS51

DIOPT Version :10

• Sequence 1: NP_611363.2
• Gene: Vps51 / 37156
• FlyBaseID: FBgn0034380
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_037397.2
• Gene: VPS51 / 738
• HGNCID: 1172
• Length: 782
• Species: Homo sapiens
• Alignment Length: 744
• Identity: 315/744 - (42%)
• Similarity: 456/744 - (61%)
• Gaps: 30/744 - (4%)

  Fly     7 NPFDMDSSSFDAEKYLERLLKDCSLKQIMDTEAAVVKDTQTLHSDMQTLVYENYNKFISATDTIR 71
            :|.|::.:.||.|.||::|.::|.|.|:||:|..:|:..:.|.||||||||||||||||||||||
Human    59 DPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIR 123

  Fly    72 RMKDDFKQMETDVNLLMTKMQSITTFSEQITGTLQGTRSQLCRLSEKHSLLKRLQFLSTLPAKLK 136
            :||:||::||.:::.|.|.|..||.||.:|:.|||....::.:|:..|:||::||||..||::|.
Human   124 KMKNDFRKMEDEMDRLATNMAVITDFSARISATLQDRHERITKLAGVHALLRKLQFLFELPSRLT 188

  Fly   137 SLIEEQNYAQAVQDYLHAQKVFAQYGRQPSFDGIQRDCDAIMADLKEQLRSDFQRAGNTAQSLTE 201
            ..:|...|.|||:....||.|..||...|||..||.||..|.|.|.:|||..|:..|:.|....|
Human   189 KCVELGAYGQAVRYQGRAQAVLQQYQHLPSFRAIQDDCQVITARLAQQLRQRFREGGSGAPEQAE 253

  Fly   202 IGELLLQLDEKTSDLASEMLTCAGKRLHEQIVMLQDQ-----TERDMLEFVDMGIDGFLNDLALV 261
            ..||||.|.|...:|..|.|..|..||.:::..|:.:     ...|:|||.|.|..||:..|..|
Human   254 CVELLLALGEPAEELCEEFLAHARGRLEKELRNLEAELGPSPPAPDVLEFTDHGGSGFVGGLCQV 318

  Fly   262 VTSYFDMFVAKHYEHERDDFQENALQELNVFLNQNIEKYLTLVQDRVESDIGYGDTQVMLRALDR 326
            ..:|.::|.|:         .....::|..|..|...:|..||:.|:..:.|.||..:::|||||
Human   319 AAAYQELFAAQ---------GPAGAEKLAAFARQLGSRYFALVERRLAQEQGGGDNSLLVRALDR 374

  Fly   327 LHRRLQAMRNICRGLEVQRNTVSIIISAAHQLCDAHAKNLKDHFADSLSAVRLSLVSAKSDAAAG 391
            .||||:|...:.....:......|:...|.:....|.:.|:..|...|:.||.:|.:.:.....|
Human   375 FHRRLRAPGALLAAAGLADAATEIVERVARERLGHHLQGLRAAFLGCLTDVRQALAAPRVAGKEG 439

  Fly   392 LNLGDLISNLYVSMVEKIKGVLQDLLIFLRTDWSFNIKAEHKGALCVEGIRENLLIGFLRHIAKV 456
            ..|.:|::|:..|::..||..|..:.:|...:.||:.|...:|..|.:|:||.|::||:..:.:.
Human   440 PGLAELLANVASSILSHIKASLAAVHLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFVHSMCQT 504

  Fly   457 MCGF----GDASSSSPPNLLLVLSKTCLELEQQGVHILIALVDDLYEIDSENSATLTHETEICAE 517
            ...|    |:...::||.|||:||:.||:.|...:..::.|.|:.:.:  ::...:|..:.:|||
Human   505 AQSFCDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLV--QDQFPVTPVSTLCAE 567

  Fly   518 MRETAQSLLDAYVRLQGTNISQMLRKSVETRDWLNCLEPRSVRAVMKRVVEELGSIETVVASLYE 582
            .||||:.||..||::||..|||||||||||||||:.||||:||||||||||:..:|:..|..|||
Human   568 ARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAIDVQVGLLYE 632

  Fly   583 ANTNATSGFRTTASSDSSRKTYFSNFASTSKPQYRSNWSNYTPS-QLESSYVSNIHRLFSERVEI 646
                  .|.|...|||||::|:....:|..:.:|.   .:|||| .::::.:|||.:|||||:::
Human   633 ------EGVRKAQSSDSSKRTFSVYSSSRQQGRYA---PSYTPSAPMDTNLLSNIQKLFSERIDV 688

  Fly   647 FTSVEFTKASIIMGIIKIGLKTLLECVRLRTFSKFGLQQIQVDAHYLQMNLWRFVSDENLVNFLL 711
            |:.|||.|.|::.|||||.|||||||||||||.:|||||:|||.|:||:.|||||:||.||:.||
Human   689 FSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLWRFVADEELVHLLL 753

  Fly   712 DEILGSAVQRCLESVLMEPNAVEIICERG 740
            ||::.||..||.:.|.|||:.||:|||||
Human   754 DEVVASAALRCPDPVPMEPSVVEVICERG 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps51	NP_611363.2	Vps51	11..95	CDD:462568	45/83 (54%)
		Cast	<22..>248	CDD:431111	104/230 (45%)
VPS51	NP_037397.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Vps51	63..147	CDD:462568	45/83 (54%)
		COG2	79..>242	CDD:473160	81/162 (50%)