DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps51 and Vps51

DIOPT Version :9

Sequence 1:	NP_611363.2	Gene:	Vps51 / 37156	FlyBaseID:	FBgn0034380	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001074510.1	Gene:	Vps51 / 68505	MGIID:	1915755	Length:	782	Species:	Mus musculus

Alignment Length:	744	Identity:	315/744 - (42%)
Similarity:	460/744 - (61%)	Gaps:	30/744 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NPFDMDSSSFDAEKYLERLLKDCSLKQIMDTEAAVVKDTQTLHSDMQTLVYENYNKFISATDTIR 71
            :|.|::.:.||.|.||::|.::|.|.|:||:|..:|:..:.|.||||||||||||||||||||||
Mouse    59 DPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIR 123

  Fly    72 RMKDDFKQMETDVNLLMTKMQSITTFSEQITGTLQGTRSQLCRLSEKHSLLKRLQFLSTLPAKLK 136
            :||:||::||.:::.|.|.|..||.||.:|:.|||....::.:|:..|:||::||||..||::|.
Mouse   124 KMKNDFRKMEDEMDRLATNMAVITNFSARISATLQDRHERITKLAGVHALLRKLQFLFELPSRLT 188

  Fly   137 SLIEEQNYAQAVQDYLHAQKVFAQYGRQPSFDGIQRDCDAIMADLKEQLRSDFQRAGNTAQSLTE 201
            ..:|...|.|||:....|:.|..||...|||..||.||..|.|.|.:|||..|:...:.|....|
Mouse   189 KCVELGAYGQAVRYQGRARAVLQQYQHLPSFRAIQDDCQVITARLAQQLRQRFREGCSGAPEQAE 253

  Fly   202 IGELLLQLDEKTSDLASEMLTCAGKRLHEQIVMLQDQ-----TERDMLEFVDMGIDGFLNDLALV 261
            ..||||.|.|...:|..|.|..|..||.|::..|:.:     ...|:|||.|.|.:||:..|..|
Mouse   254 CVELLLALGEPAEELCEEFLAHARGRLEEELSSLEAELGPSPPAPDVLEFTDRGGNGFVGGLCQV 318

  Fly   262 VTSYFDMFVAKHYEHERDDFQENALQELNVFLNQNIEKYLTLVQDRVESDIGYGDTQVMLRALDR 326
            ..:|.::|.|:         .....::|..|..:...:|..||:.|:..:.|..|..:::|||||
Mouse   319 AAAYQELFAAQ---------GPAGAEKLAAFAQELGGRYFALVERRLAQEQGGSDNSLLVRALDR 374

  Fly   327 LHRRLQAMRNICRGLEVQRNTVSIIISAAHQLCDAHAKNLKDHFADSLSAVRLSLVSAKSDAAAG 391
            .||||:|...:.....:..:...|:...|.:....|.:.||..|..||:.||.:|.:.:.....|
Mouse   375 FHRRLRAPGALLAAAGLSESATEIVERVARERLSHHLQGLKAAFLSSLTDVRQALAAPRLAGKEG 439

  Fly   392 LNLGDLISNLYVSMVEKIKGVLQDLLIFLRTDWSFNIKAEHKGALCVEGIRENLLIGFLRHIAKV 456
            .:|.:|::|:..|::..||..|..:.:|...:.||:.|...:|..|.:|:||.|::||:|.:.:.
Mouse   440 PSLAELLANVASSILSHIKTSLASVHLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFIRSMCQT 504

  Fly   457 MCGF----GDASSSSPPNLLLVLSKTCLELEQQGVHILIALVDDLYEIDSENSATLTHETEICAE 517
            ...|    |:...::||.|||:||:.||:.|...:..::.|.|:.:.:  ::.:.:|..:.:|||
Mouse   505 AQSFCDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLV--QDQSPVTPVSTLCAE 567

  Fly   518 MRETAQSLLDAYVRLQGTNISQMLRKSVETRDWLNCLEPRSVRAVMKRVVEELGSIETVVASLYE 582
            .||||:.||..||::||..|||||||||||||||:.||||:||||||||||:..:|:..|..|||
Mouse   568 ARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAIDVQVGLLYE 632

  Fly   583 ANTNATSGFRTTASSDSSRKTYFSNFASTSKPQYRSNWSNYTPS-QLESSYVSNIHRLFSERVEI 646
                  .|.|...|||||::|:....:|..:.:|.   .:|||| .::::.:|||.:|||||:::
Mouse   633 ------EGVRKAQSSDSSKRTFSVYSSSRQQGRYA---PSYTPSAPMDTNLLSNIQKLFSERIDV 688

  Fly   647 FTSVEFTKASIIMGIIKIGLKTLLECVRLRTFSKFGLQQIQVDAHYLQMNLWRFVSDENLVNFLL 711
            |:.|||.|.|::.|||||.|||||||||||||.:|||||:|||.|:||:.|||||:||.||:.||
Mouse   689 FSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLWRFVADEELVHLLL 753

  Fly   712 DEILGSAVQRCLESVLMEPNAVEIICERG 740
            ||::.||..||.:.|.|||:.||:|||||
Mouse   754 DEVVASAALRCPDPVPMEPSVVEVICERG 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps51	NP_611363.2	Vps51	11..95	CDD:400855	45/83 (54%)
Vps51	NP_611363.2	Dor1	51..210	CDD:418560	78/158 (49%)
Vps51	NP_001074510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Vps51	63..147	CDD:285862	45/83 (54%)
		Dor1	101..262	CDD:302817	79/160 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849449
Domainoid	1	1.000	459	1.000	Domainoid score	I487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34675
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1085
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54424
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005127
OrthoInspector	1	1.000	-	-		oto92994
orthoMCL	1	0.900	-	-		OOG6_103074
Panther	1	1.100	-	-	LDO	PTHR15954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2898
SonicParanoid	1	1.000	-	-		X4148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930