DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps51 and vps51

DIOPT Version :9

Sequence 1:	NP_611363.2	Gene:	Vps51 / 37156	FlyBaseID:	FBgn0034380	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001027521.1	Gene:	vps51 / 613113	XenbaseID:	XB-GENE-1005391	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	334/743 - (44%)
Similarity:	467/743 - (62%)	Gaps:	23/743 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ETKANPFDMDSSSFDAEKYLERLLKDCSLKQIMDTEAAVVKDTQTLHSDMQTLVYENYNKFISAT 67
            |....|.|:|...|:.|.||.:|.|:.||.|:||.||.:|:..::|.|:||||||||||||||||
Frog    36 ERHLEPTDVDGVHFNPELYLTKLRKESSLSQLMDVEADMVRQIRSLDSEMQTLVYENYNKFISAT 100

  Fly    68 DTIRRMKDDFKQMETDVNLLMTKMQSITTFSEQITGTLQGTRSQLCRLSEKHSLLKRLQFLSTLP 132
            ||||:||:|||:||.:::.|.|.|..||.||.:|:.|||....|:.:||..|:||::||||..||
Frog   101 DTIRKMKNDFKKMEDEMDGLATNMAVITEFSARISSTLQERHQQITKLSGVHTLLRKLQFLFELP 165

  Fly   133 AKLKSLIEEQNYAQAVQDYLHAQKVFAQYGRQPSFDGIQRDCDAIMADLKEQLRSDFQRAGNTAQ 197
            |:||..||...|||||..:..|:.|..||...|||.|||.||.||||.|.:.||..|:...::.|
Frog   166 ARLKKCIELGAYAQAVSYHSKARSVLHQYQHMPSFHGIQTDCQAIMAGLADTLRQRFRDPASSPQ 230

  Fly   198 SLTEIGELLLQLDEKTSDLASEMLTCAGKRLHEQIVMLQDQTERDMLEFVDMGIDGFLNDLALVV 262
            .|:|..|:||.|:|....|..|.|.....||...:..||:  ..|:|||||.|..||::|..|:.
Frog   231 DLSECVEMLLNLEEPAHLLCDEFLAHGRGRLASHLSDLQE--SGDILEFVDRGCGGFISDACLLA 293

  Fly   263 TSYFDMFVAKHYEHERDDFQENALQELNVFLNQNIEKYLTLVQDRVESDIGYGDTQVMLRALDRL 327
            .||..:|     ..|.....:.|..:|..||.:....|..||:.|:..:...||..:::|||||.
Frog   294 ASYQSLF-----SKEAGSTAQMAEAKLTSFLEELSTGYFELVEKRLRQEKSLGDNSLLVRALDRF 353

  Fly   328 HRRLQAMRNICRGLEVQRNTVSIIISAAHQLCDAHAKNLKDHFADSLSAVRLSLVSAKSDAAAGL 392
            ||||||...:..|....|....|::.||.:....:.:.|||.|...|:.||.:|.:.:.......
Frog   354 HRRLQAPSKLVPGCGFNRRGTEIVVRAAQERLAQYLQALKDFFQGCLTDVRQALAAPRLPGKEMP 418

  Fly   393 NLGDLISNLYVSMVEKIKGVLQDLLIFLRTDWSFNIKAEHKGALCVEGIRENLLIGFLRHI---A 454
            .||||::.|..|::.:||.||..:.:|...|.:|:.|...||..|.:|:||.|::.|::.:   |
Frog   419 ALGDLLAGLSASVLNQIKTVLAAVHLFTAKDVAFSDKPYFKGEFCSQGVREGLIVAFIKSVCQTA 483

  Fly   455 KVMCGF-GDASSSSPPNLLLVLSKTCLELEQQGVHILIALVDDLYEIDSENSATLTHETEICAEM 518
            :..|.. |:..:|:||.|||:||:.||:.|...:..::.|.|:  :...::.:.:|..:.:|:..
Frog   484 RQFCEIPGEKGTSTPPALLLLLSRLCLDYETSTISYILTLTDE--QFLGQDHSPVTPVSSLCSLA 546

  Fly   519 RETAQSLLDAYVRLQGTNISQMLRKSVETRDWLNCLEPRSVRAVMKRVVEELGSIETVVASLYEA 583
            |.|||:||:.||:.||..:|||||||||||||:..:|||:||||||||||::..::..|..|||
Frog   547 RSTAQTLLNQYVKSQGLVVSQMLRKSVETRDWVTTIEPRNVRAVMKRVVEDITGVDVQVGLLYE- 610

  Fly   584 NTNATSGFRTTASSDSSRKTYFSNFASTSKPQYRSNWSNYTPS-QLESSYVSNIHRLFSERVEIF 647
                 .|.|...|||||::|:  :..|:|:.|.|...| |||| .::::.:|||.:|||||::||
Frog   611 -----EGVRKAHSSDSSKRTF--SVYSSSRLQGRYAQS-YTPSAPMDTNLLSNIQKLFSERIDIF 667

  Fly   648 TSVEFTKASIIMGIIKIGLKTLLECVRLRTFSKFGLQQIQVDAHYLQMNLWRFVSDENLVNFLLD 712
            ::|:|.|.||:.|||||.|||.|||||||||.::||||||||.||||:.|||||||||||:.|||
Frog   668 STVQFNKVSILTGIIKISLKTFLECVRLRTFGRYGLQQIQVDCHYLQLYLWRFVSDENLVHCLLD 732

  Fly   713 EILGSAVQRCLESVLMEPNAVEIICERG 740
            |::|||..|||:...||.:.:|:|||||
Frog   733 EVVGSAAHRCLDPAPMEQSVIEVICERG 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps51	NP_611363.2	Vps51	11..95	CDD:400855	47/83 (57%)
Vps51	NP_611363.2	Dor1	51..210	CDD:418560	86/158 (54%)
vps51	NP_001027521.1	Vps51	49..129	CDD:312284	47/79 (59%)
vps51	NP_001027521.1	Dor1	83..243	CDD:327536	87/159 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I388
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34675
Inparanoid	1	1.050	585	1.000	Inparanoid score	I988
OMA	1	1.010	-	-		QHG54424
OrthoDB	1	1.010	-	-		D1305393at2759
OrthoFinder	1	1.000	-	-		FOG0005127
OrthoInspector	1	1.000	-	-		otm48180
Panther	1	1.100	-	-	LDO	PTHR15954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2898
SonicParanoid	1	1.000	-	-		X4148
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110