DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps51 and vps51

DIOPT Version :9

Sequence 1:	NP_611363.2	Gene:	Vps51 / 37156	FlyBaseID:	FBgn0034380	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001036200.1	Gene:	vps51 / 559339	ZFINID:	ZDB-GENE-030131-6008	Length:	827	Species:	Danio rerio

Alignment Length:	797	Identity:	346/797 - (43%)
Similarity:	493/797 - (61%)	Gaps:	74/797 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NPFDMDSSSFDAEKYLERLLKDCSLKQIMDTEAAVVKDTQTLHSDMQTLVYENYNKFISATDTIR 71
            :|.|::...||.|.||.:|.|:|||.::||.|:.:||..::|.||||||||||||||||||||||
Zfish    42 DPCDINGPHFDPEIYLNKLRKECSLTELMDHESCMVKQIRSLDSDMQTLVYENYNKFISATDTIR 106

  Fly    72 RMKDDFKQMETDVNLLMTKMQSITTFSEQITGTLQGTRSQLCRLSEKHSLLKRLQFLSTLPAKLK 136
            :||:|||:||.:::.|...|.:||.||.:|:||||...:|:.:||..|:||::||||..|||:|.
Zfish   107 KMKNDFKKMEDEMDCLSANMAAITEFSARISGTLQDQHAQITKLSGVHTLLRKLQFLFELPARLN 171

  Fly   137 SLIEEQNYAQAVQDYLHAQKVFAQYGRQPSFDGIQRDCDAIMADLKEQLRSDFQRAGNTAQSLTE 201
            ..:|.|.|||||..:..|:.|..||...|||.|||.||..||..|.:|||..|:..|::|:.|:|
Zfish   172 KCLELQAYAQAVSSHRRARCVLQQYSHMPSFRGIQDDCHVIMEQLAQQLRQKFRDGGSSAKDLSE 236

  Fly   202 IGELLLQLDEKTSDLASEMLTCAGKRLHEQIVMLQDQTE-------------------------- 240
            ..||||||||...:|..:.|:.|..||...:..|:.:.:
Zfish   237 CVELLLQLDEPAEELCDKFLSHAQSRLEADLQGLEAELKDSAVTDTGAGSVQKTSPGSNPVSPSS 301

  Fly   241 ------------RDMLEFVDMGIDGFLNDLALVVTSYFDMFVAKHYEHE--RDDFQENALQELNV 291
                        .|:|||:|.|.:.|:::|.||:.||.::|:.:..|.|  ..:..|.|..:|:|
Zfish   302 SVSNPFLSPAAGTDILEFIDRGCNEFVSNLCLVIASYQELFINRPQESELASKNIPEMANGKLHV 366

  Fly   292 FLNQNIEKYLTLVQDRVESDIGYGDTQVMLRALDRLHRRLQAMRNICRGLEVQRNTVSIIISAAH 356
            |::....:|.:||:.|::.:.|.||..:::|||||.||||||:..:..|..|......|::.||.
Zfish   367 FVDTLAARYFSLVERRIQEEKGVGDNSLLVRALDRFHRRLQAISKLLPGSAVPSQGTEIVVRAAR 431

  Fly   357 QLCDAHAKNLKDHFADSLSAVRL------------------SLVSAKSDAAAGLNLGDLISNLYV 403
            :....:...|:..:.|||:.||.                  :||...|...|..:|.:|:::|..
Zfish   432 ERIKQYLSALQTFYHDSLTDVRQALAAPRLSVGGASASGGGALVGGASSKDAPPSLPELLTSLSN 496

  Fly   404 SMVEKIKGVLQDLLIFLRTDWSFNIKAEHKGALCVEGIRENLLIGFLRHI---AKVMC-GFGDAS 464
            .::.::|.||..:.:|...|.:|:.|...||..|.:|:||.|::.|::.|   ::..| ..||..
Zfish   497 FILNQLKSVLASVHLFTAKDITFSNKPYFKGEFCSQGVREGLVVSFIKFICQSSRQYCESAGDRG 561

  Fly   465 SSSPPNLLLVLSKTCLELEQQGVHILIALVDDLYEIDSENSATLTHETEICAEMRETAQSLLDAY 529
            .|:||.|||:||:.||:.|...:..::.|.|:.:.:  ::...:|..|.:|||.||.||.||:.|
Zfish   562 GSTPPALLLLLSRLCLDYETSTISYILTLTDEQFLV--QHHTPVTPVTALCAEAREAAQKLLNHY 624

  Fly   530 VRLQGTNISQMLRKSVETRDWLNCLEPRSVRAVMKRVVEELGSIETVVASLYEANTNATSGFRTT 594
            |::||..||||||||||||||:|.:|||:||||||||||:..||:..|..|||      .|.|..
Zfish   625 VKVQGLIISQMLRKSVETRDWVNTIEPRNVRAVMKRVVEDTTSIDVQVGLLYE------EGVRKA 683

  Fly   595 ASSDSSRKTYFSNFASTSKPQYRSNWSNYTPS-QLESSYVSNIHRLFSERVEIFTSVEFTKASII 658
            .|||||::|:  :..|:|:.|.|.. .:|||| .::::.:||||:|||||::||:.|||.|.|::
Zfish   684 HSSDSSKRTF--SVYSSSRQQIRYA-PSYTPSAPMDTNLLSNIHKLFSERIDIFSPVEFNKVSVL 745

  Fly   659 MGIIKIGLKTLLECVRLRTFSKFGLQQIQVDAHYLQMNLWRFVSDENLVNFLLDEILGSAVQRCL 723
            .|||||.|||.|||||||||.::||||||||.|||||.|||||||||||:||||||:|||..|||
Zfish   746 TGIIKISLKTFLECVRLRTFGRYGLQQIQVDCHYLQMYLWRFVSDENLVHFLLDEIVGSAAHRCL 810

  Fly   724 ESVLMEPNAVEIICERG 740
            :...||.:.:|:|||||
Zfish   811 DPSPMEQSVIEVICERG 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps51	NP_611363.2	Vps51	11..95	CDD:400855	47/83 (57%)
Vps51	NP_611363.2	Dor1	51..210	CDD:418560	88/158 (56%)
vps51	NP_001036200.1	Vps51	46..131	CDD:285862	48/84 (57%)
		Dor1	84..245	CDD:302817	89/160 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..304		0/24 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595083
Domainoid	1	1.000	500	1.000	Domainoid score	I341
eggNOG	1	0.900	-	-		E1_KOG2346
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34675
Inparanoid	1	1.050	603	1.000	Inparanoid score	I903
OMA	1	1.010	-	-		QHG54424
OrthoDB	1	1.010	-	-		D1305393at2759
OrthoFinder	1	1.000	-	-		FOG0005127
OrthoInspector	1	1.000	-	-		oto40325
orthoMCL	1	0.900	-	-		OOG6_103074
Panther	1	1.100	-	-	LDO	PTHR15954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2898
SonicParanoid	1	1.000	-	-		X4148
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800