DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15073 and ZAP1

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_012479.1	Gene:	ZAP1 / 853390	SGDID:	S000003592	Length:	880	Species:	Saccharomyces cerevisiae

Alignment Length:	647	Identity:	128/647 - (19%)
Similarity:	225/647 - (34%)	Gaps:	176/647 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CLNNVNDTDTIRIFEDVGLSLNVANVLAKYFWFEPKSDD--PISTVI------------CLTCWN 56
            |..:.:.|...:..:| ..|.|..:|..||..|..:|.|  |.|..:            |.:...
Yeast   294 CTASTSATSGHKFVQD-HQSSNNDDVFHKYCKFCEESTDNQPCSKHMHLESKPPQLPPKCSSLRK 357

  Fly    57 QVND-------FHQFYVAVESAHRLLTERFSLKS-----------GQDQGKVEHGEDSEQQEEEQ 103
            ..|.       :|:..:..:...::|.:..::.|           ..|.....:|.|.......:
Yeast   358 PTNTLQGTNHAYHEHILNTDMDLKILEDLCNISSLYEVPFGKHINHHDHNNAGNGCDGSSTGNNE 422

  Fly   104 DEDQELGL----------PGSEGGSFTNEQFLTEVIAQQEQ---QTDSNPPKEQFIKEDNATVND 155
            :.:|.:.|          ..:..||..|....|....|...   |..|:.|....| .:|:.::.
Yeast   423 NGNQTMNLLLSSINRCNPKNNLNGSNNNTAGATSTDHQHHHHRIQFHSHKPNRNNI-VNNSGISA 486

  Fly   156 PETSATLPTEQRRETRSTAKSK---AHHSLPPSTPPEKSNSVANKSKAKRTPCKAEGTPQKSKRY 217
            ..|:|.|......:..|...|.   .:.|.|||.|     .|.::::..|     ...|.|....
Yeast   487 ANTTADLTNNDLNDLISREYSYERFRNQSEPPSLP-----KVTHQNQKNR-----RSWPTKDLES 541

  Fly   218 ADYKQCMLDIDAKISAHMRLTCDV----CHEGQETFLLLCK----------------HMLQEHHR 262
            .|:......:.:.||..::.|..:    |.:.::...|.||                |:|::|..
Yeast   542 TDFSSLEDSLPSSISPPIQTTSTINFNWCFKEEKNNDLKCKWKECPESCSSLFDLQRHLLKDHVS 606

  Fly   263 KGY-----AICCNKKFYKRSFLTD-------HID---------RHADPEKFKCTQCDKRFADKQC 306
            :.:     .:.||  :....||.|       ||:         :.|:|:.|......|.
Yeast   607 QDFKHPMEPLACN--WEDCDFLGDDTCSIVNHINCQHGINFDIQFANPDSFLPGSISKE------ 663

  Fly   307 LRNHELLKHH------PEEEKTFMCEQCPKRYTKQYLLDQHRV--IHKERNVVC--DLCERRFPN 361
                   |||      |:..:....:..|...:..   |...:  |.:...|:|  |.|.:.|.:
Yeast   664 -------KHHLLHCPNPQTHEVSKADGAPDMTSAN---DVSNIPPIKQPEQVICQWDGCNKSFSS 718

  Fly   362 QSLLCTHVKMAHGNYGTMCDICAQVIRGRAAFQRHQLEHAGVTEPKVQCDICGSWH------KNK 420
            ...|..|::..|            :.||::.:|                  | .||      ..:
Yeast   719 AQELNDHLEAVH------------LTRGKSEYQ------------------C-LWHDCHRTFPQR 752

  Fly   421 HSLKKHVRRHNG-TAATCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITLREHMT 484
            ..|.:|::.|:. ....|..|.:...:...::.|.| .|..::.::|.:|||.|..:.:|:.|:.
Yeast   753 QKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTR-THSGEKPYKCHICNKKFAISSSLKIHIR 816

  Fly   485 MHTGEVLYKCPHCPKTFN--SNANQH--THRR--KCH--PKEFEEARKARTEKRKAIEEETP 538
            .||||...:|..|.|.||  ||.::|  ||::  ||.  .|.|::..|..::|.|...|..|
Yeast   817 THTGEKPLQCKICGKRFNESSNLSKHIKTHQKKYKCSDCSKSFDDLGKLNSQKVKCALERKP 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	17/92 (18%)
		C2H2 Zn finger	269..286	CDD:275368	7/32 (22%)
		C2H2 Zn finger	294..316	CDD:275368	2/21 (10%)
		C2H2 Zn finger	325..345	CDD:275368	2/21 (10%)
		C2H2 Zn finger	352..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	410..430	CDD:275368	5/25 (20%)
		C2H2 Zn finger	437..458	CDD:275368	4/20 (20%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	494..512	CDD:275368	10/21 (48%)
ZAP1	NP_012479.1	COG5048	292..761	CDD:227381	92/527 (17%)
		C2H2 Zn finger	743..762	CDD:275368	3/18 (17%)
		SUF4-like	766..>814	CDD:411020	11/48 (23%)
		C2H2 Zn finger	770..795	CDD:411020	5/25 (20%)
		C2H2 Zn finger	770..790	CDD:275368	4/20 (20%)
		C2H2 Zn finger	798..818	CDD:275368	7/19 (37%)
		zf-H2C2_2	810..834	CDD:404364	9/23 (39%)
		C2H2 Zn finger	826..846	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000