DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and ZNF335

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	585	Identity:	133/585 - (22%)
Similarity:	207/585 - (35%)	Gaps:	193/585 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SLKSGQDQGKVEHGEDSEQQEEEQDEDQELGLPGSEGGSFTNEQFLTEVIAQQEQQTDSNP---- 140
            |.||.:::|         .:||:.|:..:.|                 .|...|:.:|.||
Human   291 STKSQEEEG---------PEEEDDDDIVDAG-----------------AIDDLEEDSDYNPAEDE 329

  Fly   141 PKEQFIKEDNATVNDPETSATLPTEQRR-------------------ETRSTAKSKAHHSLPPST 186
            |:.:.::....|   |.|    |..:||                   |......|::..|.|...
Human   330 PRGRQLRLQRPT---PST----PRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQ 387

  Fly   187 PPEKSNS-----VANKSKAKRTPCKAEGTPQKSKRYADYKQCMLDIDAKISAHMRLTCDVCHE-- 244
            .||..:|     :....|..|||.:| |..|.              ||:.:|.   :|...|:
Human   388 DPEAPSSSGPGHLVAMGKVSRTPVEA-GVSQS--------------DAENAAP---SCPDEHDTL 434

  Fly   245 ----GQETFLLLCKHMLQEHHRKGY----------AIC--CNKKFYKRSFLTDHIDRH--ADPEK 291
                |:.:     :..|.:.:||.|          .:|  |..:|.....|..|::.|  .||:.
Human   435 PRRRGRPS-----RRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQL 494

  Fly   292 FKCTQCDKRFADKQCLRNHELLKHHPEEEKTFMCEQCPKRYTKQYLLD--QHRVIH----KER-- 348
            |||.||..|......|:.| :..|  ...|.:.|::|  .||..|..|  :|..:|    |:|
Human   495 FKCLQCSYRSRRWSSLKEH-MFNH--VGSKPYKCDEC--SYTSVYRKDVIRHAAVHSRDRKKRPD 554

  Fly   349 ------NVVCDLCERRFPNQSLLCTHVKMAHGNYGTMCDICAQVIRGRAAFQRHQLEHAGVTEPK 407
                  :..|.:|.|.:|.|..|..|:|                            .|:  ||..
Human   555 PTPKLSSFPCPVCGRVYPMQKRLTQHMK----------------------------THS--TEKP 589

  Fly   408 VQCDICGSWHKNKHSLKKHVRRHNGTAAT----CDLCGKVSPNRSAMLSHQRYVHLTDRKHECSV 468
            ..||.||...|.:::.|.|:..|....|.    |:.|..|..::.|:|:|| ..|::|:..:||.
Human   590 HMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQ-LSHVSDKPFKCSF 653

  Fly   469 C-NKAFKKAITLREHMTMHTGEVLYKCPHCPKTFNSNANQHTHRRKCHPKEFEEARKARTEK--- 529
            | .:.|::...|......|||...:.|.:|..:.....|...|.|..|...|||..:...|:
Human   654 CPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPS 718

  Fly   530 -------RKAIEE-------------------ETPSVLTISTGEDGESHSILLTNTEEDIKGDTI 568
                   .:.|||                   |.|...|  |.:..|:.|:|.::|   :.|.||
Human   719 RRRPFFSLQQIEELKQQHSAAPGPPPSSPGPPEIPPEAT--TFQSSEAPSLLCSDT---LGGATI 778

Fly 569 568
Human 779 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	269..286	CDD:275368	4/16 (25%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	325..345	CDD:275368	7/21 (33%)
		C2H2 Zn finger	352..370	CDD:275368	7/17 (41%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..458	CDD:275368	7/20 (35%)
		C2H2 Zn finger	466..486	CDD:275368	5/20 (25%)
		C2H2 Zn finger	494..512	CDD:275368	4/17 (24%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442		40/201 (20%)
		C2H2 Zn finger	467..487	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..517	CDD:275368	6/20 (30%)
		zf-H2C2_2	509..534	CDD:290200	8/29 (28%)
		C2H2 Zn finger	529..545	CDD:275370	5/15 (33%)
		C2H2 Zn finger	564..584	CDD:275368	8/47 (17%)
		zf-H2C2_2	577..600	CDD:290200	10/52 (19%)
		zf-C2H2	590..612	CDD:278523	7/21 (33%)
		C2H2 Zn finger	592..612	CDD:275368	7/19 (37%)
		C2H2 Zn finger	623..643	CDD:275368	7/20 (35%)
		C2H2 Zn finger	651..672	CDD:275368	5/20 (25%)
		C2H2 Zn finger	680..699	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763		4/32 (13%)
		PRK04654	<795..911	CDD:135173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1097	CDD:290620
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:290200
		C2H2 Zn finger	1105..1126	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010