DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and ZNF407

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001371404.1	Gene:	ZNF407 / 55628	HGNCID:	19904	Length:	2248	Species:	Homo sapiens

Alignment Length:	681	Identity:	146/681 - (21%)
Similarity:	229/681 - (33%)	Gaps:	231/681 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RLLTERFSLKSGQDQGKVEHGEDSEQQEEEQDEDQELGLPGSEGGSFTNEQFLTEVIAQQEQQTD 137
            |:..|:.:|:|| .|.:|..|...|..:..| ||..||          |:    |::...:.:|
Human  1269 RITREQGNLESG-GQNRVARGHGLEDLKGVQ-EDPVLG----------NK----EILMNSQHET- 1316

  Fly   138 SNPPKEQFIKEDNATVNDPETSATLPTEQRRETRSTAKSKAH---------HSLPPSTPPE---- 189
                  :||.|::.    |.:.:|:.:....||..:...|..         .|:.....||
Human  1317 ------EFILEEDG----PASDSTVESSDVYETIISIDDKGQAMYSFGRFDSSIIRIKNPEDGEL 1371

  Fly   190 ----KSNSVANKSKAKRTPCK--AEGTPQKSKRYADYKQCMLDIDAKISAHMRLTCDVCHEGQET 248
                :...:|...:....|.|  |:|..:|...           .:.|....|:.||.|     .
Human  1372 IDQSEEGLIATGVRISELPLKDCAQGVKKKKSE-----------GSSIGESTRIRCDDC-----G 1420

  Fly   249 FL----------LLCKHMLQEHHRKGYAICCNKKFYKRSFLTDHI-------DRHADPEK----- 291
            ||          :..||..:|.|  .:.:.|.|.||..|.|..|:       :..|..|:
Human  1421 FLADGLSGLNVHIAMKHPTKEKH--FHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGG 1483

  Fly   292 --FKCTQCDKRFADKQCL------RNHELLK-------------HHPEEE--------------- 320
              |||.:|.:.|..:|.|      ::.|||:             :...||
Human  1484 ATFKCVKCTEPFDSEQNLFLHIKGQHEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRS 1548

  Fly   321 ----------------KTFMCEQC---------------------------------PKRYTKQY 336
                            |.|.|:.|                                 .|::...:
Human  1549 SNSMAFLAHIRTHTGSKPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTH 1613

  Fly   337 LLDQHRV-IHKERNVVCDLCERRFPNQSLLCTHVKMAHGNYGTMC--DICAQVIRGRAAFQRHQL 398
            ||.:|.| ..|||...|.||:|.|..:..|..|:|:..|.....|  ..|.......:|.:.|..
Human  1614 LLGKHGVGTPKERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTWPTCHYSFLTASAMKDHYR 1678

  Fly   399 EHAGVTEPKVQCDICGSWHKNKHSLKKHVRRHNGTAA-TCDLCGKVSPNRSAMLSHQRYVHLTDR 462
            .|.|  |....||:||.....:|:|.||.|:|.|... .||.|...|..:|.:..|:| ||..::
Human  1679 THTG--EKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKR-VHTGEK 1740

  Fly   463 KHECSVCNKAFKKAITLREHMTMHTGE----VLYKCPHCPKTFNSNANQHTHRRKCHP------- 516
            .:.|..|:.....|..:|:|: :|||:    .:|.||.|....|.......|.::.||
Human  1741 PYRCPWCDYRSNCAENIRKHI-LHTGKHEGVKMYNCPKCDYGTNVPVEFRNHLKEQHPDIENPDL 1804

  Fly   517 ---------KEFE----------------------------EARKARTEKRKAIEEETPSVLTIS 544
                     |.:|                            :.:..|:.:|.|...|....:.|.
Human  1805 AYLHAGIVSKSYECRLKGQGATFVETDSPFTAAALAEEPLVKEKPLRSSRRPAPPPEQVQQVIIF 1869

  Fly   545 TGEDGESHSILLTNTEEDIKGDTIEFTLCLS 575
            .|.|||   ..|..:.|:....|:: ||.::
Human  1870 QGYDGE---FALDPSVEETAAATLQ-TLAMA 1896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	1/4 (25%)
		C2H2 Zn finger	269..286	CDD:275368	7/23 (30%)
		C2H2 Zn finger	294..316	CDD:275368	8/40 (20%)
		C2H2 Zn finger	325..345	CDD:275368	7/53 (13%)
		C2H2 Zn finger	352..370	CDD:275368	7/17 (41%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		C2H2 Zn finger	437..458	CDD:275368	7/20 (35%)
		C2H2 Zn finger	466..486	CDD:275368	5/19 (26%)
		C2H2 Zn finger	494..512	CDD:275368	5/17 (29%)
ZNF407	NP_001371404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	217..238	CDD:275368
		C2H2 Zn finger	246..268	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..322
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..515
		C2H2 Zn finger	590..614	CDD:275371
		C2H2 Zn finger	617..639	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..847
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..962
		C2H2 Zn finger	1416..1445	CDD:275371	9/35 (26%)
		C2H2 Zn finger	1446..1468	CDD:275371	7/21 (33%)
		C2H2 Zn finger	1488..1509	CDD:275371	5/20 (25%)
		C2H2 Zn finger	1539..1561	CDD:275368	0/21 (0%)
		zf-H2C2_2	1557..1578	CDD:404364	4/20 (20%)
		C2H2 Zn finger	1569..1589	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1597..1617	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1630..1650	CDD:275368	8/19 (42%)
		zf-H2C2_2	1642..1669	CDD:404364	6/26 (23%)
		C2H2 Zn finger	1658..1680	CDD:275368	4/21 (19%)
		C2H2 Zn finger	1688..1708	CDD:275368	9/19 (47%)
		zf-H2C2_2	1700..1725	CDD:404364	10/24 (42%)
		zf-H2C2_5	1714..1738	CDD:404746	9/24 (38%)
		C2H2 Zn finger	1716..1736	CDD:275368	7/20 (35%)
		zf-H2C2_2	1728..1753	CDD:404364	6/25 (24%)
		C2H2 Zn finger	1744..1761	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100