DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15073 and CG6254

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_649983.2	Gene:	CG6254 / 41244	FlyBaseID:	FBgn0037794	Length:	634	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	137/571 - (23%)
Similarity:	229/571 - (40%)	Gaps:	76/571 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CRLCLNN--VNDTDTIRIFEDVGLSLNVANVLAKYFWFEPKSDDPISTVICLTCWNQVNDFHQFY 65
            ||||...  .|.....|..:....:..:|..:.||||.:.|.:|.:|..:|..|:..::...:|.
  Fly    22 CRLCSKEHPTNQNVFFREAKQNSWASTMAMTIGKYFWVDIKREDELSNFLCSECFTLMDCLIEFS 86

  Fly    66 VAVESAHRLLTERFSLKSG---------QDQGKVEHG---------EDSEQQEEEQ--DEDQELG 110
            ..|.....|.::...|:|.         :|.|....|         ::|..|.:|.  .|:|.:.
  Fly    87 ERVRKVQILFSKLQLLQSNNLMDYEKIREDCGVATDGWKHIMLGAVDESLPQNDEVFISEEQPIV 151

  Fly   111 LPGSEGGSFTNE-----QFLTEVIAQQEQQTDSNPPKEQFIKEDNATVNDPE---TSATLPTEQR 167
            ..........:|     .||.|....||:|   :.|||:.:.|:...::..|   ....:..:..
  Fly   152 CQTETSSKMKSEILMIPNFLVEKQCLQEKQ---DFPKEEDVIEEEMQISGVEEEILEEDVEEDLA 213

  Fly   168 RETRSTAKSKAHHSLPPSTPPEKSNSVANKSKAK-RTPCKAEGTPQKSK-RYADYKQCMLDIDAK 230
            .|...|.:.:.      .|..|:..:|..:.:.: .|.|..|.....:: ||.:..|.:  .:::
  Fly   214 EEEVETVEEEI------DTVGEEVEAVEEELETQDATDCLVEEVEHMTEDRYIEESQII--EESQ 270

  Fly   231 ISAHMRLTCDVCHEGQETFLLLCKHMLQEHHRKGYAICCN---KKFYKRSFLTDHIDRHAD-PEK 291
            :|.....|.::.....:...:..|..::       :|..|   ::...|..:||..|..:: |..
  Fly   271 VSDFNMETYEIVQHNPQKEPVETKDTVE-------SIESNEDTQEDISREHVTDEEDEISEVPAM 328

  Fly   292 FKCTQCDKRFADKQCLRNHELLKHH------PEEEKTFMCEQCPKRYTKQYLLDQHRVIH----- 345
            :||..|.|.:...:..:.|....|:      |:.|    |.||...:.....|..|...|
  Fly   329 YKCNICKKPYKKPKAYKRHMEEVHNTVADDLPQLE----CNQCKLCFPTVAQLHAHHRTHVRAKP 389

  Fly   346 KERNVVCDLCERRFPNQSLLCTHVKMAHGNYGT-MCDICAQVIRGRAAFQRHQLEHAGVTEPKVQ 409
            |..| .|..||:||.....|..|::..|..... :||:|.:........:.|:|.|  ..|...:
  Fly   390 KTDN-CCPHCEKRFTTSGTLKRHIEGIHNQIKPYVCDLCGKSFNYITGLKDHKLVH--TDECPFE 451

  Fly   410 CDICGSWHKNKHSLKKHVRRHNGTAATCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFK 474
            |.:|....||...||.|:..|:.....|.:||.....|.....| :.||...|:.:|.||..|||
  Fly   452 CPVCKRGFKNNARLKIHLDTHSAEIYECTVCGLKLKTRRTFNKH-KLVHSDTRQFKCEVCGSAFK 515

  Fly   475 KAITLREHMTMHTGEVLYKCPHCPKTFNSNANQHTHRRKCHPKEF--EEAR 523
            ::.||:.|:.:|||...|||..|.:.|.:.:|..:|:|:.||||.  ||||
  Fly   516 RSKTLKAHLILHTGIRPYKCNFCGRDFANGSNCRSHKRQAHPKELAEEEAR 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	19/76 (25%)
		C2H2 Zn finger	269..286	CDD:275368	5/19 (26%)
		C2H2 Zn finger	294..316	CDD:275368	4/21 (19%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..370	CDD:275368	7/17 (41%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..458	CDD:275368	5/20 (25%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..512	CDD:275368	5/17 (29%)
CG6254	NP_649983.2	zf-AD	21..99	CDD:285071	19/76 (25%)
		COG5048	<353..554	CDD:227381	60/208 (29%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	395..416	CDD:275368	7/20 (35%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	479..499	CDD:275368	5/20 (25%)
		C2H2 Zn finger	507..527	CDD:275368	9/19 (47%)
		zf-H2C2_2	520..544	CDD:290200	10/23 (43%)
		C2H2 Zn finger	535..553	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010