DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15073 and Zfp462

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_038966959.1	Gene:	Zfp462 / 362522	RGDID:	1562123	Length:	2565	Species:	Rattus norvegicus

Alignment Length:	925	Identity:	148/925 - (16%)
Similarity:	234/925 - (25%)	Gaps:	424/925 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LAKYFWFEPKSDDPISTVI-------CLTC-------WNQVNDFHQFYV-AVESAHRLLTERFSL 81
            :|...|..|....|..|:.       |..|       |:..|.:..|:. |:.....:|.:....
  Rat  1343 MATKLWAGPDPSSPTLTMSAEAKTYRCRDCAFEAVSIWDITNHYQAFHPWAMNGDESVLLDIIKE 1407

  Fly    82 KSGQDQ---------GKVEHGEDS-----EQQEEEQDEDQELGLPGSEGGSFTNEQFLTE----V 128
            |.|.|:         |.| :.|:|     .:||.|..||..|....|...:..|....:.    .
  Rat  1408 KDGVDKALLAPEELIGAV-NCENSLPNPLPEQEAECPEDARLSPEKSIHLASANPAISSTPYQCT 1471

  Fly   129 IAQQE--------------------------QQTDSNP--------------------------- 140
            :.|.|                          |..|.||
  Rat  1472 VCQSEYNNLHGLLTHYGKKHPGMKVKAADFAQDVDINPGAVYKCRHCPYINTRIHGVLTHYQKRH 1536

  Fly   141 PKEQFIKEDNATVNDPETSATLPTEQRRETR--------------------STAKSKAHH----- 180
            |..:...||  .|:|.|.||.:......||.                    :..|.|.|:
  Rat  1537 PAIKVTAED--FVHDVEQSADITQNDVEETSRIFKQGYGAYRCKLCPYTHGTLEKLKIHYEKYHN 1599

  Fly   181 ------------SLPPSTPPEKSNSVANKSKAKRTPCKAEGTPQKSKRYADYKQCMLDIDAKISA 233
                        .||.|..||.:..| :.|:...|..:....|..:..::         .:.:.:
  Rat  1600 QPEFDVFSPSPPKLPVSLEPEITTEV-SPSQVSMTEEEVGEDPMSTAHFS---------TSHLVS 1654

  Fly   234 HMRLTCDVCH------------------------EGQETFL--LLCKHM------LQEHHRKGY- 265
            |....|.:|.                        ||:....  .||.:.      |..|::|.:
  Rat  1655 HTVFRCQLCKYFCSTRKGIARHYRIKHNNVRAQPEGKNNLFKCALCAYTNPIRKGLAAHYQKRHD 1719

  Fly   266 ------------------------------------------------AICCNKKFYKRSFLTDH 282
                                                            ::|..:.|.|:..::.:
  Rat  1720 IDAYYTHCLAASRTISDKPNKVIIPSPPKDDSPQLSEELRRAVEKKKCSLCSFQSFSKKGIVSHY 1784

  Fly   283 IDRH---------------------AD------------------PE-----------KFKCTQC 297
            :.||                     ||                  ||           .|:|.:|
  Rat  1785 MKRHPGVFPKKQHASKLGGYFTAVYADEHEKPPLMEEEGRSGFERPEVEGEAQDIEWLPFRCIKC 1849

  Fly   298 DK-RFADKQCLRNHELLKHHPEEEK---------------TFMCEQCPKRYTKQYLLDQHRVIH- 345
            .| .|:..:.|..| ...||..:.|               ||.|:.|..:......|..|..||
  Rat  1850 FKLSFSTAELLCMH-YTDHHSRDLKRDFVILGSGPRFQNSTFQCKHCDSKLQSTAELTSHLNIHN 1913

  Fly   346 ---------------------------------------------KERNVV---CDLCERRFPNQ 362
                                                         |||.||   |..|....|..
  Rat  1914 EEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLEEAPKIKERKVVGYKCKFCVEVHPTL 1978

  Fly   363 SLLCTHVKMAHGNYGTM------------------------------------------------ 379
            ..:|.|:: .|..||::
  Rat  1979 RAICNHLR-KHVQYGSVPAVSAAVKQEAEDPSHLFLDGFEAARDASGTLVGRVDGGHCLLDGMLE 2042

  Fly   380 ---------CDICAQVIRGRAAFQRHQLEHAGVT----EPKVQCDICGSWHKNKHSLKKHVRRHN 431
                     |..|.:|:......:.|:..|..:.    |.|..|..|......:|:|.:|::.|:
  Rat  2043 DETRPGGYHCSQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHH 2107

  Fly   432 G--TAATCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITLREH-MTMHTGEVLYK 493
            |  ....|.||...|...|.:.:|....|..:..::||.|:.:......|:|| :.:|...:...
  Rat  2108 GHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLP 2172

  Fly   494 CPHCPKTFNSNANQHTHRRKCHPKE----------------------FEEARKARTEKRKAIEEE 536
            .|......:|:|  |...:|..|.|                      ::.|..||...|  :...
  Rat  2173 RPRIVSLLSSHA--HHSSQKATPAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNNSR--VSPV 2233

  Fly   537 TPSVLTISTGEDGES 551
            .||.....|.:..|:
  Rat  2234 PPSGTAAGTEQKAEA 2248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	12/60 (20%)
		C2H2 Zn finger	269..286	CDD:275368	2/16 (13%)
		C2H2 Zn finger	294..316	CDD:275368	6/22 (27%)
		C2H2 Zn finger	325..345	CDD:275368	4/19 (21%)
		C2H2 Zn finger	352..370	CDD:275368	5/17 (29%)
		C2H2 Zn finger	410..430	CDD:275368	5/19 (26%)
		C2H2 Zn finger	437..458	CDD:275368	6/20 (30%)
		C2H2 Zn finger	466..486	CDD:275368	6/20 (30%)
		C2H2 Zn finger	494..512	CDD:275368	4/17 (24%)
Zfp462	XP_038966959.1	C2H2 Zn finger	2052..2072	CDD:275368	4/19 (21%)
		zf-H2C2_5	2084..2108	CDD:404746	6/23 (26%)
		C2H2 Zn finger	2086..2106	CDD:275368	5/19 (26%)
		C2H2 Zn finger	2115..2136	CDD:275368	6/20 (30%)
		C2H2 Zn finger	2144..2165	CDD:275368	6/20 (30%)
		C2H2 Zn finger	2315..2335	CDD:275368
		C2H2 Zn finger	2361..2381	CDD:275368
		C2H2 Zn finger	2389..2410	CDD:275368
		C2H2 Zn finger	2475..2495	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100