DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and Zfp407

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_008770443.2	Gene:	Zfp407 / 307213	RGDID:	1310645	Length:	2255	Species:	Rattus norvegicus

Alignment Length:	675	Identity:	142/675 - (21%)
Similarity:	214/675 - (31%)	Gaps:	242/675 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LKSGQDQGKVEHGEDSEQQEEEQDEDQELGLPGSEGGSFTNEQFLTEVIAQQEQQT-------DS 138
            ||..|....:|..|.....:.|.:...|...|.|.|.:..|:.:.|.:....:.||       ||
  Rat  1284 LKDVQANSNLESKEILMNSQHEPEVILEEDAPASIGTAENNDAYETIISIDDKGQTMYSFGRFDS 1348

  Fly   139 NPPKEQFIK-EDNATVNDPETSATLPTEQRRETRSTAKSKAHHSLPPSTPPEKSNSVANKSKAKR 202
            :..:   || ||...|..||                                 ...:....|...
  Rat  1349 SIIR---IKTEDGELVEQPE---------------------------------EGLMVTGGKVSE 1377

  Fly   203 TPCK--AEGTPQKSKRYADYKQCMLDIDAKISAHMRLTCDVCHEGQETFL----------LLCKH 255
            .|.|  |:|..:|....:.:.:           ..|:.||.|     .||          :..||
  Rat  1378 LPLKDCAQGLKKKKVEGSSFGE-----------STRIRCDDC-----GFLADGLSGLNVHIAMKH 1426

  Fly   256 MLQEHHRKGYAICCNKKFYKRSFLTDHI-------DRHADPEK-------FKCTQCDKRFADKQC 306
            ..:|.|  .:.:.|.|.||..|.|..|:       :..|..|:       |||.:|.:.|..:|.
  Rat  1427 PTKEKH--FHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQN 1489

  Fly   307 L------RNHELLK-------------HHPEEE-------------------------------K 321
            |      ::.|||:             :...||                               |
  Rat  1490 LFLHIKGQHEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTHTGSK 1554

  Fly   322 TFMCEQC---------------------------------PKRYTKQYLLDQHRV-IHKERNVVC 352
            .|.|:.|                                 .|::...:||.:|.| ..|||...|
  Rat  1555 PFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPKERKFTC 1619

  Fly   353 DLCERRFPNQSLLCTHVKMAHGNYGTMC--DICAQVIRGRAAFQRHQLEHAGVTEPKVQCDICGS 415
            .||:|.|..:..|..|||:..|.....|  ..|.......:|.:.|...|.|  |....||:||.
  Rat  1620 HLCDRSFTEKWALNNHVKLHTGEKPFKCTWPTCHYSFLTASAMKDHYRTHTG--EKSFLCDLCGF 1682

  Fly   416 WHKNKHSLKKHVRRHNGTAA-TCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITL 479
            ....:|:|.||.|:|.|... .||.|...|..:|.:..|:| ||..::.:.|..|:.....|..:
  Rat  1683 AGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKR-VHTGEKPYRCPWCDYRSNCAENI 1746

  Fly   480 REHMTMHTGE----VLYKCPHCPKTFNSNANQHTHRRKCHP------------------------ 516
            |:|: :|||:    .:|.||.|....|.......|.::.||
  Rat  1747 RKHI-LHTGKHEGVKMYNCPKCDYGTNVPVEFRNHLKEQHPDIENPDLAYLHAGKQAELPSDVQG 1810

  Fly   517 ---KEFE----------------------------EARKARTEKRKAIEEETPSVLTISTGEDGE 550
               |.:|                            :.:..|:.||:|...|....:.|..|.|||
  Rat  1811 IVSKSYECRLKGQGATFVETDSPFTAATLAEESPVKEKSLRSSKRQASSPEQVQQVIIIQGYDGE 1875

  Fly   551 SHSILLTNTEEDIKGDTIEFTLCLS 575
               ..|..:.|:....|:: ||.::
  Rat  1876 ---FALDASVEETAAATLQ-TLAMA 1896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	269..286	CDD:275368	7/23 (30%)
		C2H2 Zn finger	294..316	CDD:275368	8/40 (20%)
		C2H2 Zn finger	325..345	CDD:275368	7/53 (13%)
		C2H2 Zn finger	352..370	CDD:275368	7/17 (41%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		C2H2 Zn finger	437..458	CDD:275368	7/20 (35%)
		C2H2 Zn finger	466..486	CDD:275368	5/19 (26%)
		C2H2 Zn finger	494..512	CDD:275368	5/17 (29%)
Zfp407	XP_008770443.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100