DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and Zfp236

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_006255073.1	Gene:	Zfp236 / 291409	RGDID:	1309670	Length:	1848	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	128/525 - (24%)
Similarity:	198/525 - (37%)	Gaps:	104/525 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 EQDEDQELGLPGSEGGSFTNEQFLTEVIAQQEQQTDSNPPKEQ-------------FIKED---N 150
            :|.|.|...:.|.:     |.|.:|:||.|..:.::..|.:.|             .|.:|   .
  Rat   338 QQVEAQVSSVSGEQ-----NSQAVTDVIQQLLELSEPGPVEAQQSPQSGRQLSVTVGINQDILQQ 397

  Fly   151 ATVNDPETS---ATLPTEQRRETRSTAKSKAHHSLPPSTPPEKSNSV-ANKSKAKRTPCKAEGTP 211
            |..|...:|   |..|::......||..|::.|:  .|...|:::.: |.:.|.:.:|.|||
  Rat   398 ALENSGLSSLPVAAPPSDCSHAQTSTVSSQSPHT--SSVSAEQADPMDAEQEKGQESPEKAE--- 457

  Fly   212 QKSKRYADYKQCMLDIDAKISAHMRLTCDVCHEGQETFLLLCKHMLQEHHRKGYAIC--CNKKFY 274
            :|.|:....|...|                            ...::|.:...:.:|  |.|:|.
  Rat   458 KKEKKILKKKSPFL----------------------------PGSIREENGVRWHVCPYCTKEFR 494

  Fly   275 KRSFLTDHIDRHADPEKFKCTQCDKRFADKQCLRNHELLKHHPEEEKTFMCEQCPKRYTKQYLLD 339
            |.|.|..||..|...:.|||.||.:.||.|..|..|  :|.| ...|.|.|:.|.|.::....|.
  Rat   495 KPSDLVRHIRIHTHEKPFKCPQCFRAFAVKSTLTAH--IKTH-TGIKAFKCQYCMKSFSTSGSLK 556

  Fly   340 QHRVIHK-ERNVVCDLCERRFPNQSLLCTHVKMAHGNYGTMCDICAQ--VIRGRAAFQRHQLEHA 401
            .|..:|. .|...|..|:::|.......||| .:|..:..:..:..|  .::|||......:...
  Rat   557 VHIRLHTGVRPFACPHCDKKFRTSGHRKTHV-ASHFKHTELRKMRQQRKPVKGRAGKSSAPVPDI 620

  Fly   402 GVTEP--------------------------------KVQCDICGSWHKNKHSLKKHVRRHNGTA 434
            .:.||                                ..:|..|...:|....||:|:|.|.|..
  Rat   621 PLQEPILITDLGLIQPIPKNQFFQNYFNNNFGNEADRPYKCFYCHRAYKKSCHLKQHIRSHTGEK 685

  Fly   435 A-TCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITLREHMTMHTGEVLYKCPHCP 498
            . .|..||:...:...:.:|.| .|...:..:|.:||.||....:||.||.:|.....|.||:|.
  Rat   686 PFKCSQCGRGFVSAGVLKAHVR-THTGLKSFKCLICNGAFTTGGSLRRHMGIHNDLRPYMCPYCQ 749

  Fly   499 KTFNSNANQHTHRRKCHPKEFEEARKARTEKRKAIEEET--PSVLTISTGEDGESHSILLTNTEE 561
            |||.::.|...| .|.|..|..:..:...|.....||.|  ...:.:|.....|..|..|..|.|
  Rat   750 KTFKTSLNCKKH-MKTHRYELAQQLQQHQEASSMDEESTVDQQSIQVSAPMPVEIESAELQQTPE 813

  Fly   562 DIKGD 566
            .:..|
  Rat   814 TVAAD 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	269..286	CDD:275368	8/16 (50%)
		C2H2 Zn finger	294..316	CDD:275368	9/21 (43%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..370	CDD:275368	5/17 (29%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..458	CDD:275368	5/20 (25%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..512	CDD:275368	8/17 (47%)
Zfp236	XP_006255073.1	C2H2 Zn finger	41..61	CDD:275368
		COG5048	<52..234	CDD:227381
		C2H2 Zn finger	70..90	CDD:275368
		C2H2 Zn finger	97..117	CDD:275368
		C2H2 Zn finger	125..145	CDD:275368
		C2H2 Zn finger	157..177	CDD:275368
		COG5048	197..>550	CDD:227381	63/252 (25%)
		zf-C2H2	199..221	CDD:278523
		C2H2 Zn finger	201..221	CDD:275368
		zf-H2C2_2	214..238	CDD:290200
		C2H2 Zn finger	229..249	CDD:275368
		zf-H2C2_2	241..266	CDD:290200
		C2H2 Zn finger	257..278	CDD:275368
		C2H2 Zn finger	289..310	CDD:275368
		zf-C2H2	484..506	CDD:278523	9/21 (43%)
		C2H2 Zn finger	486..506	CDD:275368	9/19 (47%)
		zf-H2C2_2	498..522	CDD:290200	9/23 (39%)
		C2H2 Zn finger	514..534	CDD:275368	9/21 (43%)
		zf-H2C2_2	527..551	CDD:290200	9/26 (35%)
		C2H2 Zn finger	542..562	CDD:275368	5/19 (26%)
		zf-H2C2_2	554..579	CDD:290200	7/24 (29%)
		C2H2 Zn finger	570..590	CDD:275368	6/20 (30%)
		COG5048	654..1059	CDD:227381	48/167 (29%)
		C2H2 Zn finger	661..681	CDD:275368	7/19 (37%)
		zf-H2C2_2	673..698	CDD:290200	9/24 (38%)
		C2H2 Zn finger	689..709	CDD:275368	5/20 (25%)
		C2H2 Zn finger	717..737	CDD:275368	9/19 (47%)
		zf-H2C2_2	729..754	CDD:290200	12/24 (50%)
		C2H2 Zn finger	745..765	CDD:275368	9/20 (45%)
		COG5048	963..1306	CDD:227381
		zf-C2H2	971..993	CDD:278523
		C2H2 Zn finger	973..993	CDD:275368
		zf-H2C2_2	985..1010	CDD:290200
		C2H2 Zn finger	1001..1021	CDD:275368
		zf-H2C2_2	1014..1038	CDD:290200
		C2H2 Zn finger	1029..1049	CDD:275368
		zf-H2C2_2	1041..1066	CDD:290200
		C2H2 Zn finger	1173..1193	CDD:275368
		zf-H2C2_2	1185..1209	CDD:290200
		C2H2 Zn finger	1201..1221	CDD:275368
		C2H2 Zn finger	1229..1249	CDD:275368
		zf-H2C2_2	1241..1266	CDD:290200
		C2H2 Zn finger	1257..1277	CDD:275370
		Hus1	1363..1597	CDD:281934
		C2H2 Zn finger	1663..1684	CDD:275368
		C2H2 Zn finger	1692..1712	CDD:275368
		COG5048	1718..>1787	CDD:227381
		C2H2 Zn finger	1728..1748	CDD:275368
		zf-H2C2_2	1741..1765	CDD:290200
		C2H2 Zn finger	1756..1776	CDD:275368
		zf-H2C2_2	1768..1793	CDD:290200
		C2H2 Zn finger	1784..1802	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930