DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and Zfp335

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_001093956.2	Gene:	Zfp335 / 259270	RGDID:	628751	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	127/621 - (20%)
Similarity:	204/621 - (32%)	Gaps:	216/621 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 EDSEQQEEEQDEDQELGLPGSEGGSFTNEQFLTEVIAQQEQQTDSNPPKEQFIKEDNATVNDPET 158
            |:..::|||.|:..:.|                 .|...|:.:|.||.:::
  Rat   300 EEGPEEEEEDDDIVDAG-----------------AIDDLEEDSDYNPAEDE-------------- 333

  Fly   159 SATLPTEQ----RRETRSTAKSKAHHSLPPSTPPEKSNSVANKSKAKRTPCKAEGTPQKSKRYAD 219
                |..:    :|.|.||.:.:.....|...|..:::.:.:          ..|.|..|.:...
  Rat   334 ----PRGRQLRLQRPTPSTLRPRRRPGRPRKLPRLETSDLHD----------GIGEPLVSSQSTQ 384

  Fly   220 YKQCMLDIDAKISAHMR---------LTCDVCHEGQETFLLLC---------------KHMLQEH 260
            ....:.|::|..|:.:|         :...|.....|.....|               :..|.:.
  Rat   385 SPPELQDLEAPSSSDLRALGKVGRGLVETGVSQSDAENAAPSCQDEADVPPRRRGRPSRRFLGKK 449

  Fly   261 HRKGY----------AIC--CNKKFYKRSFLTDHIDRH--ADPEKFKCTQCDKRFADKQCLRNHE 311
            :||.|          .:|  |..:|.....|..|::.|  .||:.|||.||..|......|:.|
  Rat   450 YRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEH- 513

  Fly   312 LLKHHPEEEKTFMCEQCPKRYTKQYLLD--QHRVIH----KER--------NVVCDLCERRFPNQ 362
            :..|  ...|.:.|::|  .||..|..|  :|..:|    |:|        :..|.:|.|.:|.|
  Rat   514 MFNH--VGSKPYKCDEC--SYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQ 574

  Fly   363 SLLCTHVKMAHGNYGTMCDICAQVIRGRAAFQRHQLEHAGVTEPKVQCDICGSWHKNKHSLKKHV 427
            ..|..|:|                            .|:  ||....||.||...|.:::.|.|:
  Rat   575 KRLTQHMK----------------------------THS--TEKPHMCDKCGKSFKKRYTFKMHL 609

  Fly   428 RRHNGTAAT----CDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVC-NKAFKKAITLREHMTMHT 487
            ..|....|.    |:.|..|..::.|:|:|| ..|::|:..:||.| .:.|::...|......||
  Rat   610 LTHIQAVANRRFKCEFCEFVCEDKKALLNHQ-LSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHT 673

  Fly   488 GEVLYKCPHCPKTFNSNANQHTHRRKCHPKEFEEARKARTEK----------RKAIEE------- 535
            |...:.|.:|..:.....|...|.|..|...|||..:...|:          .:.|||
  Rat   674 GAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSA 738

  Fly   536 -----------------------ETPSVL--------TISTGEDGESHSILLTNTEED------- 562
                                   |||.:|        ||...:..|..:.:.|.|..|
  Rat   739 APGPPLSSAGPEAPQEPAPFQPPETPPLLCPDALGGATIIYQQGAEESTAMATQTALDLLLNMSA 803

  Fly   563 -------------IKGDTIEFTLCLSA------DTT 579
                         :|.:.:|..|..:|      |||
  Rat   804 QRELGATALQVAVVKSEDVEAELTSTARQPSSEDTT 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	269..286	CDD:275368	4/16 (25%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	325..345	CDD:275368	7/21 (33%)
		C2H2 Zn finger	352..370	CDD:275368	7/17 (41%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..458	CDD:275368	7/20 (35%)
		C2H2 Zn finger	466..486	CDD:275368	5/20 (25%)
		C2H2 Zn finger	494..512	CDD:275368	4/17 (24%)
Zfp335	NP_001093956.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..398		23/142 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..442		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..766		3/33 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100