DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and Zfy2

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_033597.2	Gene:	Zfy2 / 22768	MGIID:	99213	Length:	777	Species:	Mus musculus

Alignment Length:	609	Identity:	141/609 - (23%)
Similarity:	222/609 - (36%)	Gaps:	153/609 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LNNVNDTDTIRIFEDVGLSLNVANVLAKYFWFEPKSDDPISTVICLTCWNQVNDFHQFYVAVESA 71
            :|..::||:.::.|                     :...:..|..|...::|:|..:...||||.
Mouse   221 MNAESETDSSKLDE---------------------ASPEVIKVCILKADSEVDDVGETIQAVESE 264

  Fly    72 HRLLTERFSLKSGQDQGKVEH---------GEDSEQQEEEQ-----DEDQELGLPGSEGGSFTNE 122
                |:..:.....||....|         ..||:::||:.     |||        .||:..:
Mouse   265 ----TDNGNEAEVTDQRTSIHVPRVNIYMLASDSQKEEEDTKVIVGDED--------AGGTAAD- 316

  Fly   123 QFLTEVIAQQEQQTDSNPPKEQFI----------KEDNATVNDPETSATLPTEQR----RETRST 173
                  ..:.|||.|.:..|..|:          ..|...|.:...||.|..::.    |..:..
Mouse   317 ------TPEHEQQMDVSEIKAAFLPIAWTAAYDNNSDEIEVQNATASAMLHHDESGGLDRVPKQK 375

  Fly   174 AKSKAHHSLPPSTPPEKSNSVANKSKAKRT-PCKAEGTPQKSKRY------------ADYK---- 221
            :|.|..   |.|...:.:..||...:..|. ||...|...|:||:            |:.|
Mouse   376 SKKKKR---PESKQYQSAIFVAPDGQTLRVYPCMFCGKKFKTKRFLKRHIKNHPEYLANKKYHCT 437

  Fly   222 QCMLDIDAKISAH-----MRLT--------CDVC-----HEG----------------------Q 246
            :|....:.|||.|     .:||        ||.|     |.|                      :
Mouse   438 ECDYSTNKKISLHNHMESHKLTIKTEKTTECDDCRKNLSHAGTMHTEKGVNKTCKCKFCDYETAE 502

  Fly   247 ETFLLLCKHMLQEHHRKGYAIC--CNKKFYKRSFLTDHIDRHADPEKFKCTQCDKRFADKQCLRN 309
            :|  ||..|:|..|.:|...||  |.|.|...|.|..||..|...:.::|..|:.:.||...|:.
Mouse   503 QT--LLNHHLLVVHRKKFPHICGECGKGFRHPSALKKHIRVHTGEKPYECQYCEYKSADSSNLKT 565

  Fly   310 HELLKHHPEEEKTFMCEQCPKRYTKQYLLDQHRVIHKE-RNVVCDLCERRFPNQSLLCTHVKMAH 373
            |...||  .:|....|..|...::......||.|:|:| |...|..|..:..|.|.|..|:...|
Mouse   566 HIKSKH--SKEIPLKCGICLLTFSDTKEAQQHAVLHQESRTHQCSHCNHKSSNSSDLKRHIISVH 628

  Fly   374 GN-YGTMCDICAQVIRGRAAFQRHQLEHAGVTEPKVQCDIC-----GSWHKNKHSLKKHVRRHNG 432
            .. |...||:|::.....:..::|...|.  ::...||..|     ..:..:.|.|..|.:   .
Mouse   629 TKAYPHKCDMCSKGFHRPSELKKHVATHK--SKKMHQCRHCDFKSPDPFLLSHHILSAHTK---N 688

  Fly   433 TAATCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITLREH-MTMHTGEVLYKCPH 496
            ....|..|.|....:..:.:|.: .|.:.:.::|..|..:.|.|...:.| :::||.:..::|..
Mouse   689 VPFKCKRCKKEFQQQCELQTHMK-THSSRKVYQCEYCEYSTKDASGFKRHVISIHTKDYPHRCDF 752

  Fly   497 CPKTFN--SNANQHTHRRKCHPKE 518
            |.|.|.  |..|||..|   |.||
Mouse   753 CKKGFRRPSEKNQHIMR---HHKE 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	13/70 (19%)
		C2H2 Zn finger	269..286	CDD:275368	7/16 (44%)
		C2H2 Zn finger	294..316	CDD:275368	7/21 (33%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..370	CDD:275368	6/17 (35%)
		C2H2 Zn finger	410..430	CDD:275368	5/24 (21%)
		C2H2 Zn finger	437..458	CDD:275368	4/20 (20%)
		C2H2 Zn finger	466..486	CDD:275368	5/20 (25%)
		C2H2 Zn finger	494..512	CDD:275368	8/19 (42%)
Zfy2	NP_033597.2	Zfx_Zfy_act	68..388	CDD:282547	41/209 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..234		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..389		5/30 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		2/12 (17%)
		C2H2 Zn finger	405..425	CDD:275370	5/19 (26%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		COG5048	<442..681	CDD:227381	61/244 (25%)
		C2H2 Zn finger	493..514	CDD:275368	5/22 (23%)
		zf-C2H2	520..542	CDD:278523	9/21 (43%)
		C2H2 Zn finger	522..542	CDD:275368	8/19 (42%)
		zf-H2C2_2	534..556	CDD:290200	6/21 (29%)
		C2H2 Zn finger	550..571	CDD:275368	6/20 (30%)
		C2H2 Zn finger	579..599	CDD:275368	5/19 (26%)
		C2H2 Zn finger	607..628	CDD:275368	6/20 (30%)
		C2H2 Zn finger	636..685	CDD:275368	10/50 (20%)
		C2H2 Zn finger	693..713	CDD:275368	4/20 (20%)
		C2H2 Zn finger	721..742	CDD:275368	5/20 (25%)
		C2H2 Zn finger	750..770	CDD:275368	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000