DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and Zfy1

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_033596.3	Gene:	Zfy1 / 22767	MGIID:	99212	Length:	782	Species:	Mus musculus

Alignment Length:	568	Identity:	128/568 - (22%)
Similarity:	206/568 - (36%)	Gaps:	159/568 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KSDDPISTVI--C-LTCWNQVNDFHQFYVAVESAHRLLTERFSLKSGQDQGKVEHGED------- 95
            |.|:....||  | |...::|::..:...||||         ..|:|.:....:....
Mouse   231 KLDEASPEVIKVCILKADSEVDELGETIHAVES---------ETKNGNEAEVTDQSTSIRVPRVN 286

  Fly    96 -----SEQQEEEQDEDQELGLPGSEGGSFTNEQFLTEVIAQQEQQTDSNPPKEQFI------KED 149
                 |:.|:||:|.:..:| ....||:..:       ..:.|||.|.:..|..|:      ..|
Mouse   287 IYMSASDSQKEEEDTEVIVG-DEDAGGTAAD-------TPEHEQQMDVSEIKAAFLPIAWTAAYD 343

  Fly   150 NATVNDPETSATLPTEQRRETRSTAKSKAHHSLPPSTPPEKSNSVANKSKAKRTPCKAEGTPQKS 214
            |   |..|      .|.:..|.|...::.........|.:       |||.|:.|        :|
Mouse   344 N---NSDE------IEDQNVTASALLNQDESGGLDRVPKQ-------KSKKKKRP--------ES 384

  Fly   215 KRYADYKQCMLDIDAKISAHMRLTCDVCHEGQETFLLLCKHMLQEHHRKGYAICCNKKFYKRSFL 279
            |:|                  :....|..:||...:..|             :.|.|||..:.||
Mouse   385 KQY------------------QSAIFVAPDGQTLRVYPC-------------MFCGKKFKTKRFL 418

  Fly   280 TDHIDRHADPE-----KFKCTQCDKRFADKQCLRNHELLKHHP---EEEKTFMCEQCPKRYTKQY 336
            ..|...|  ||     |:.||:||.....|..|.||  ::.|.   :.|||..|:.|.|..:...
Mouse   419 KRHTKNH--PEYLANKKYHCTECDYSTNKKISLHNH--MESHKLTIKTEKTTECDDCRKNLSHAG 479

  Fly   337 LLDQHRVIHKERNV----VCDLCERRFPNQSLLCTHVKMAH-GNYGTMCDICAQVIRGRAAFQRH 396
            .|..|:.:|.|:.|    .|..|:.....|:||..|:.:.| ..:..:|..|.:..|..:|.::|
Mouse   480 TLCTHKTMHTEKGVNKTCKCKFCDYETAEQTLLNHHLLVVHRKKFPHICGECGKGFRHPSALKKH 544

  Fly   397 QLEHAGVTEPKVQCDICGSWHKNKHSLKKHVR-RHN----------------------------- 431
            ...|.|  |...:|..|.....:..:||.|:: :|:
Mouse   545 IRVHTG--EKPYECQYCEYKSADSSNLKTHIKSKHSKEIPLKCGICLLTFSDNKEAQQHAVLHQE 607

  Fly   432 GTAATCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITLREHMTMHTGEVLYKCPH 496
            .....|..|...|.|.|.:..|...||.....|:|.:|:|.|.:...|::|:..|..:.:::|.|
Mouse   608 SRTHQCSHCNHKSSNSSDLKRHIISVHTKAYPHKCDMCSKGFHRPSELKKHVATHKSKKMHQCRH 672

  Fly   497 CPKTFNSN---------ANQHTHR-----RKCHPKEFEEARKARTEKR 530
            |  .|||.         .:.||..     ::| .|||::..:.:|..:
Mouse   673 C--DFNSPDPFLLSHHILSAHTKNVPFKCKRC-KKEFQQQCELQTHMK 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	11/39 (28%)
		C2H2 Zn finger	269..286	CDD:275368	7/16 (44%)
		C2H2 Zn finger	294..316	CDD:275368	8/21 (38%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..370	CDD:275368	6/17 (35%)
		C2H2 Zn finger	410..430	CDD:275368	5/20 (25%)
		C2H2 Zn finger	437..458	CDD:275368	6/20 (30%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		C2H2 Zn finger	494..512	CDD:275368	8/31 (26%)
Zfy1	NP_033596.3	Zfx_Zfy_act	68..388	CDD:282547	43/215 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..386		7/40 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		5/16 (31%)
		C2H2 Zn finger	405..425	CDD:275370	8/32 (25%)
		C2H2 Zn finger	436..456	CDD:275370	8/21 (38%)
		C2H2 Zn finger	468..488	CDD:275368	5/19 (26%)
		C2H2 Zn finger	499..520	CDD:275368	6/20 (30%)
		COG5048	<513..687	CDD:227381	38/177 (21%)
		zf-C2H2	526..548	CDD:278523	5/21 (24%)
		C2H2 Zn finger	528..548	CDD:275368	5/19 (26%)
		zf-H2C2_2	540..562	CDD:290200	7/23 (30%)
		C2H2 Zn finger	556..577	CDD:275368	5/20 (25%)
		C2H2 Zn finger	585..605	CDD:275368	0/19 (0%)
		C2H2 Zn finger	613..634	CDD:275368	6/20 (30%)
		C2H2 Zn finger	642..691	CDD:275368	13/50 (26%)
		C2H2 Zn finger	699..719	CDD:275368	5/20 (25%)
		zf-H2C2_2	711..735	CDD:290200	1/7 (14%)
		C2H2 Zn finger	727..748	CDD:275368
		C2H2 Zn finger	756..776	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000