DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and Zfp521

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_663467.1	Gene:	Zfp521 / 225207	MGIID:	95459	Length:	1311	Species:	Mus musculus

Alignment Length:	632	Identity:	142/632 - (22%)
Similarity:	225/632 - (35%)	Gaps:	180/632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ICRLCLN------NVND-TDTIRIFEDVGLSLNVANVLAKYFWFEPKSDDPISTVICLTCWNQVN 59
            ||:.||.      |:|: ...:...:|.||.::..               |.....|..|...||
Mouse   438 ICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAM---------------PAIVYQCNFCSEVVN 487

  Fly    60 DFHQFYVAVESAHRLLTERFSLKSGQDQGK--VEH---GEDSEQQEEEQDEDQELGLPGSEGGSF 119
            |.:.....:..:|     .|:..:.:|...  ..|   |..::...||........|.||..||
Mouse   488 DLNTLQEHIRCSH-----GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGS- 546

  Fly   120 TNEQFLTEVIAQQEQQTDSNPPKEQFIKEDNAT--VNDPETSATLPTEQRRETRSTAKSKAHHSL 182
                   .|:         ..|||..::..:.:  .|.|..::.|...:..:       :.|.::
Mouse   547 -------PVL---------GTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIK-------ENHKNI 588

  Fly   183 PPSTPPEKSNSVANKSKAKR----TPCKAEGTPQK---------SKRYADY--KQC-----MLD- 226
            |.:.     |.:.|..|::.    :|...|.|..|         ::...:|  .||     .||
Mouse   589 PLAL-----NYIHNGKKSRALSPLSPVAIEQTTLKMMQTVGGGPARASGEYICNQCGAKYTSLDS 648

  Fly   227 IDAKISAHM-----RLTCDVCHE---GQETFLLLCKHM-LQEHHRKGYAIC--CNKKFYKRSFLT 280
            ....:..|:     :|||..|::   .||:.|   ||: :.......|.||  |:|:|.....|.
Mouse   649 FQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL---KHVTIHFMITSTYYICESCDKQFTSVDDLQ 710

  Fly   281 DH-IDRHADPEKFKCTQCDKRFADKQCLRNHELLKHHPEEEKTFMCEQCP---------KRYTKQ 335
            .| :|.|.. ..|:||.|.:.|..|..::.|..:| |..|:|.:.|..|.         :.:.|.
Mouse   711 KHLLDMHTF-VFFRCTLCQEVFDSKVSIQLHLAVK-HSNEKKVYRCTSCNWDFRNETDLQLHVKH 773

  Fly   336 YLLDQHRVIHK---------------------ERNVVCDLCERRFPNQSLLCTHVKMAHGNYGTM 379
            ..|:....:||                     .:...|..|.:.|....||..|::..|..:.|.
Mouse   774 NHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCRFCSKAFHAVILLEKHLREKHCVFETK 838

  Fly   380 CDICA------QVIRGRAAFQ--------RHQLEHAG------VTEPKVQCDICGSWHKNKHSLK 424
            ...|.      ||.:..|..|        .|. .|.|      .:||...|||||:.:..:..|:
Mouse   839 TPNCGTNGASEQVQKEEAELQTLLTNSQESHN-SHDGSEEDVDSSEPMYGCDICGAAYTMETLLQ 902

  Fly   425 KH-VRRHNGTAATCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITLREHMTMHTG 488
            .| :|.||           :.|..||::  ::...|....::|:||::.|.....|||||..|.|
Mouse   903 NHQLRDHN-----------IRPGESAIV--KKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLG 954

  Fly   489 EVL-YKCPHCPKTFNS--NANQH--THRR-----KCH----PKEFEE 521
            .|. |.||.|.:.|.|  ...:|  ||.:     .|.    |.:.||
Mouse   955 PVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEE 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	16/82 (20%)
		C2H2 Zn finger	269..286	CDD:275368	6/17 (35%)
		C2H2 Zn finger	294..316	CDD:275368	7/21 (33%)
		C2H2 Zn finger	325..345	CDD:275368	4/28 (14%)
		C2H2 Zn finger	352..370	CDD:275368	6/17 (35%)
		C2H2 Zn finger	410..430	CDD:275368	8/20 (40%)
		C2H2 Zn finger	437..458	CDD:275368	3/20 (15%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..512	CDD:275368	8/21 (38%)
Zfp521	NP_663467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..108
		COG5048	<83..236	CDD:227381
		C2H2 Zn finger	120..140	CDD:275368
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		C2H2 Zn finger	204..224	CDD:275368
		C2H2 Zn finger	248..265	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..398
		C2H2 Zn finger	407..428	CDD:275368
		C2H2 Zn finger	439..460	CDD:275368	5/20 (25%)
		C2H2 Zn finger	479..498	CDD:275368	5/18 (28%)
		C2H2 Zn finger	636..656	CDD:275368	4/19 (21%)
		C2H2 Zn finger	666..686	CDD:275368	7/22 (32%)
		C2H2 Zn finger	696..713	CDD:275368	5/16 (31%)
		C2H2 Zn finger	724..745	CDD:275368	7/21 (33%)
		C2H2 Zn finger	754..774	CDD:275368	3/19 (16%)
		C2H2 Zn finger	785..805	CDD:275368	0/19 (0%)
		C2H2 Zn finger	811..829	CDD:275368	6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..883		3/20 (15%)
		C2H2 Zn finger	888..909	CDD:275368	8/20 (40%)
		C2H2 Zn finger	932..952	CDD:275368	9/19 (47%)
		C2H2 Zn finger	961..981	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1136
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1258..1279	CDD:275368
		C2H2 Zn finger	1288..1307	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100