DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15073 and ZNF513

DIOPT Version :9

Sequence 1:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	NP_653232.3	Gene:	ZNF513 / 130557	HGNCID:	26498	Length:	541	Species:	Homo sapiens

Alignment Length:	532	Identity:	103/532 - (19%)
Similarity:	161/532 - (30%)	Gaps:	183/532 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GQDQGKVEHGEDSEQQEEEQDEDQELGLP-GSEGGSFTNEQFLTEVIAQQEQQTDSNPPKEQFIK 147
            |||   :|..|:.|::|.:.:.||.:|.. .|||.|......|...::..|.........|..::
Human    41 GQD---LEFEEEEEEEEGDGNSDQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVE 102

  Fly   148 EDNATVNDPETSATLPTEQRRETRSTAKSKAHHSLPPSTPPEKSNSVANKSKAKRTPCKAEGTPQ 212
            |          .|..|.|.|.|.             |....:.......:.     ||...|.|.
Human   103 E----------PARGPGEARGER-------------PGPACQLCGGPTGEG-----PCCGAGGPG 139

  Fly   213 KSKRYADYKQCMLDIDAKISAHMRLTCDVCHEGQETFLLLCKHMLQEHHRKGYAICCNKKFYKRS 277
            ..              ..:...:..:|.:|     ||:        .|:              .|
Human   140 GG--------------PLLPPRLLYSCRLC-----TFV--------SHY--------------SS 163

  Fly   278 FLTDHIDRHADPEKFKCTQCDKRFADKQCLRNHELLKHHPEE--EKTFMCEQCPKRYTKQYLLDQ 340
            .|..|:..|:..:.|:|.:|.  :|..|.:   .|.:|....  ||.:.|..||...:....|.:
Human   164 HLKRHMQTHSGEKPFRCGRCP--YASAQLV---NLTRHTRTHTGEKPYRCPHCPFACSSLGNLRR 223

  Fly   341 HRVIHK-ERNVVCDLC----------------ER-----RFPNQSLLCTHVKM------------ 371
            |:..|. .....|..|                |:     |.|..:||...:.:
Human   224 HQRTHAGPPTPPCPTCGFRCCTPRPARPPSPTEQEGAVPRRPEDALLLPDLSLHVPPGGASFLPD 288

  Fly   372 -------AHGNYGTMCD-----------------------------ICAQVIRGRAA-------- 392
                   ..|..||..:                             :|.:.:||.|.
Human   289 CGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAMCGRCMRGEAGGGASGGPQ 353

  Fly   393 ---------------------FQRHQLEHAGVTEPKVQCDICGSWHKNKHSLKKHVRRHNGTAA- 435
                                 ..||...|:|  |...:|..|.....:..:||:|.|.|.|...
Human   354 GPSDKGFACSLCPFATHYPNHLARHMKTHSG--EKPFRCARCPYASAHLDNLKRHQRVHTGEKPY 416

  Fly   436 TCDLCGKVSPNRSAMLSHQRYVHLTDRKHECSVCNKAFKKAITLREHMTMHTGEVLYKCPHCPKT 500
            .|.||.....|.:.:..|.| :|..|:...||:||.:..:::.|:.||..||||..::|..|..|
Human   417 KCPLCPYACGNLANLKRHGR-IHSGDKPFRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATCAYT 480

  Fly   501 FNSNANQHTHRR 512
            .....|...|::
Human   481 TGHWDNYKRHQK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	269..286	CDD:275368	3/16 (19%)
		C2H2 Zn finger	294..316	CDD:275368	5/21 (24%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..370	CDD:275368	7/38 (18%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	437..458	CDD:275368	6/20 (30%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	494..512	CDD:275368	5/17 (29%)
ZNF513	NP_653232.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		24/102 (24%)
		C2H2 Zn finger	152..172	CDD:275368	8/46 (17%)
		COG5048	176..>228	CDD:227381	14/56 (25%)
		C2H2 Zn finger	180..200	CDD:275368	6/24 (25%)
		zf-H2C2_2	192..217	CDD:316026	7/24 (29%)
		C2H2 Zn finger	208..228	CDD:275368	5/19 (26%)
		C2H2 Zn finger	362..382	CDD:275368	2/19 (11%)
		COG5048	<372..>450	CDD:227381	23/80 (29%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		COG5048	414..>487	CDD:227381	22/73 (30%)
		C2H2 Zn finger	418..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..493	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..541		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100