Protein Alignment Sik3 and KSP1

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_011950.1
• Gene: KSP1 / 856482
• SGDID: S000001124
• Length: 1029
• Species: Saccharomyces cerevisiae
• Alignment Length: 1062
• Identity: 208/1062 - (19%)
• Similarity: 368/1062 - (34%)
• Gaps: 300/1062 - (28%)

  Fly    65 TKVAIKIIDKTCLNEEYLNKTFREIAILKSL-RHPHITRLYEVMESQSMIYLVTEYAPNGEIFDH 128
            :||..::.:..||...|      |:.|...: ||.:|..|.:..:|    |::.||...|::::.
Yeast   117 SKVKSRLSNNICLEAMY------EVDIQTKIGRHQNIAALLDFFDS----YIIMEYCSGGDLYEA 171

  Fly   129 LVANGRMKEPEA-ARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDK-DMNIKLADFGFSNHYEEG 191
            :.|:...|:.:: ..:.||::.|:.|.|.:|:.|||:|.||:|:.. |..|||.|:|.:.  .:.
Yeast   172 IKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIKPENILISGIDWTIKLTDWGLAT--TDK 234

  Fly   192 ATLKTWCGSPPYAAPEVF-QGLE-------YDGPKSDIWSLGVVLYALVCGALPF------DGKT 242
            .::....||..|.:||:| ..|:       ||..|.|:|::|:|...:|....||      |...
Yeast   235 TSMDRNVGSERYMSPELFDSNLDIKERKEPYDCAKVDLWAMGIVFLNIVFHKNPFSIANQSDKSF 299

  Fly   243 ILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDR------RYTIKQIIKHRWLSEWQSEMQE 301
            .....:|..|  |.:...|:.:..|::|..|.::|..      |..::.:.::....|:.:.:.|
Yeast   300 CYFAANREAL--FDVFSTMAYDFFQVLRYSLTIDPANRDLKMMRTELQNLSEYTLDDEYYNNLDE 362

  Fly   302 --QERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDN 364
              :|...|..|.......||..|       .|..:.|....||   |....|....:|:|::..:
Yeast   363 GYEETMIDGLPPQPVPPSSAPVS-------LPTPISSSNKQHM---PEFKKDFNFNNVNERKRSD 417

  Fly   365 IYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITT------------------GVVDR-- 409
            :....|:.....::...:.|:.       :::...|:::|                  |..|.
Yeast   418 VSQNQNVASGFFKKPSTQQQKF-------FNQGYNTTLSTHERAKSAPKFKFKKRNKYGRTDNQF 475

  Fly   410 SEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFEL--ECLARSNDPPVNAQHLSAH 472
            |:||..|...:...|..   |...||....:..:: ..:.|::.  |...|....|.:.||  .:
Yeast   476 SKPVNIEDRKKSKILKK---SRKPLGIPTPNTHMN-NFFHDYKARDEFNTRDFFTPPSVQH--RY 534

  Fly   473 AGGGVNGANTR----RHTVGPGDVAHEQALANPNVPPIDFK----------------CPPQCSDP 517
            ..|..|..|.:    |:.....:.::....:|.|    :|.                ..|..|..
Yeast   535 MEGFSNNNNKQYRQNRNYNNNNNNSNNNHGSNYN----NFNNGNSYIKGWNKNFNKYRRPSSSSY 595

  Fly   518 TQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGP 582
            |...|....|:....|   :|.:|              :.:.||.|            |.||
Yeast   596 TGKSPLSRYNMSYNHN---NNSSI--------------NGYARRGS------------TTTV--- 628

  Fly   583 AQGQQMDTAGYYINPNCGTDPLAVQELSPLNE-----QSVA-------------QMQCCQENATG 629
                 ..:.|.||.||...     ..:||.|:     ||.|             |....|::...
Yeast   629 -----QHSPGAYIPPNARN-----HHVSPTNQFLRVPQSTAPDISTVLGGKPSYQEHYTQDSMDS 683

  Fly   630 ECNEELQSYMQKRGGTQRHTVGCTEDLSV----------------AHGS----GAGSQSQAPTTS 674
            |.:.:....:..........|...::||:                .|.|    ..|:.:...|.|
Yeast   684 EGDHDSDDVLFTLEEGDHDFVNGMDNLSINDHLPHTTVGSHNEVFVHASTNHNNNGNNNHIDTNS 748

  Fly   675 SNMRQRRTGLLTVTERPPVIPPEIIREV---ESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMG 736
            :..:..|          ..|||.:...:   .:..:.:.||..|||          |..:...:.
Yeast   749 TTNQYHR----------QYIPPPLTTSLHINNNNNESNELPDLLKS----------PASSEAHLN 793

  Fly   737 MSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLPTVQEGATIG-RYSPVRRASEGSKSQ 800
            :|.|       |:       .|::..|                    || |||   .:|:..:.:
Yeast   794 LSSG-------PI-------DPILTGN--------------------IGNRYS---HSSDSKELE 821

  Fly   801 FQGPLQECQSLQKGI-----AQRNF-LVAPSPPL-LENSISLPGSPIHGKPGMGLQLALRRGHDI 858
            .:..|...|..:.|:     .:::| |....||: ::.|.....|..|.....|.....||....
Yeast   822 QERRLSMEQKFKNGVYVPPHHRKSFNLGTQVPPMNMKTSNEATLSVSHNSVNFGGSYNSRRSSAN 886

  Fly   859 EVPPEAIKNLMPALDRL-----VKEQRVSFEIANKIISTHVVPMDLAPLLGLAAHASSAAAV--- 915
            |..|   .::..||::|     .|...|.|            |..|.|    ..|:|:..|:
Yeast   887 ESNP---LHMNKALEKLSSSPGAKSSFVGF------------PKPLLP----RNHSSTTIALQNE 932

  Fly   916 ---SGGHLDQSHFTHLQQQQQQQHMLSFSVSPLSMPQGGAVNASLTS--AKQMFG------QPIC 969
               :..:.|...|...:.:.:...|....:      :||...:|.||  .:|:||      |...
Yeast   933 DVFADSNNDAIIFEDEEYEGESDKMAHGKM------EGGDNESSSTSPDERQIFGPYEIYAQTFA 991

  Fly   970 GYTQYQPMTLALQPQHQQQLVG 991
            |.|..:.:....:...|.::||
Yeast   992 GSTHDKKLGAGRKTSIQDEMVG 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	64/249 (26%)
		UBA_SIK	335..380	CDD:270523	8/44 (18%)
KSP1	NP_011950.1	STKc_Pat1_like	17..348	CDD:270895	64/244 (26%)