Protein Alignment Sik3 and PRR1

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_012806.1
• Gene: PRR1 / 853744
• SGDID: S000001599
• Length: 518
• Species: Saccharomyces cerevisiae
• Alignment Length: 369
• Identity: 104/369 - (28%)
• Similarity: 161/369 - (43%)
• Gaps: 85/369 - (23%)

  Fly     1 MATTPTAGPAAAPPTSSTPQNY-KVP-------STSKIS--------VDKLLRVGYYELEKTIGK 49
            :.:.||....|....|....|| |.|       ||.|..        :|...|...::..:.||.
Yeast   136 VVSLPTVTEEALVNDSVDSDNYTKEPYFPESSSSTEKCDDDIFQGFLLDHWDRPLLWKKVRPIGS 200

  Fly    50 GNFAVVKL-----ATNIVTKTKVAIKII--DKTCLNEEYLNKTF--------------REIAILK 93
            |||:.|.|     .:|...| :||:|.:  .:...|.|.:|.:.              ||:.:||
Yeast   201 GNFSTVLLYELMDQSNPKLK-QVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTRELQVLK 264

  Fly    94 SLRHPHITRLYEV-----MESQSMIY--------------LVTEYAPNGEIFDHLVA-NGRMKEP 138
            ||.||.|.:|..:     :.|:..:.              ::..|.|.|::...::| |||::..
Yeast   265 SLNHPCIVKLLGINNPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMARNGRLEAW 329

  Fly   139 EAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLD---KDMN-------------IKLADFGFSNH 187
            ...|:||::|.||.|.|...::|||||.||:||.   .|:|             |:|||||....
Yeast   330 LIQRIFTEVVLAVKYLHENSIIHRDLKLENILLKYSFDDINSFRDSPIYCKQNFIELADFGLCKK 394

  Fly   188 YEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFD--GKTILELKSRV 250
            .|........|||..|.:||:..|:.|||..||.|:|||:||:|....||||  .......:||.
Yeast   395 IENNEMCTARCGSEDYVSPEILMGVPYDGHLSDTWALGVILYSLFEDRLPFDPPPNASARQRSRA 459

  Fly   251 VLGK--------FRIPFFMSQECEQLIRNMLVVEPDRRYTIKQI 286
            ...:        :|:..:.:...:|::.|.| ...::|::|.:|
Yeast   460 TSHRIARFDWRWYRLSDYKTNVGKQIVENTL-TRKNQRWSINEI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	91/314 (29%)
		UBA_SIK	335..380	CDD:270523
PRR1	NP_012806.1	S_TKc	192..508	CDD:214567	91/313 (29%)