DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and PRR1

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_012806.1	Gene:	PRR1 / 853744	SGDID:	S000001599	Length:	518	Species:	Saccharomyces cerevisiae

Alignment Length:	369	Identity:	104/369 - (28%)
Similarity:	161/369 - (43%)	Gaps:	85/369 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATTPTAGPAAAPPTSSTPQNY-KVP-------STSKIS--------VDKLLRVGYYELEKTIGK 49
            :.:.||....|....|....|| |.|       ||.|..        :|...|...::..:.||.
Yeast   136 VVSLPTVTEEALVNDSVDSDNYTKEPYFPESSSSTEKCDDDIFQGFLLDHWDRPLLWKKVRPIGS 200

  Fly    50 GNFAVVKL-----ATNIVTKTKVAIKII--DKTCLNEEYLNKTF--------------REIAILK 93
            |||:.|.|     .:|...| :||:|.:  .:...|.|.:|.:.              ||:.:||
Yeast   201 GNFSTVLLYELMDQSNPKLK-QVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTRELQVLK 264

  Fly    94 SLRHPHITRLYEV-----MESQSMIY--------------LVTEYAPNGEIFDHLVA-NGRMKEP 138
            ||.||.|.:|..:     :.|:..:.              ::..|.|.|::...::| |||::..
Yeast   265 SLNHPCIVKLLGINNPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMARNGRLEAW 329

  Fly   139 EAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLD---KDMN-------------IKLADFGFSNH 187
            ...|:||::|.||.|.|...::|||||.||:||.   .|:|             |:|||||....
Yeast   330 LIQRIFTEVVLAVKYLHENSIIHRDLKLENILLKYSFDDINSFRDSPIYCKQNFIELADFGLCKK 394

  Fly   188 YEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFD--GKTILELKSRV 250
            .|........|||..|.:||:..|:.|||..||.|:|||:||:|....||||  .......:||.
Yeast   395 IENNEMCTARCGSEDYVSPEILMGVPYDGHLSDTWALGVILYSLFEDRLPFDPPPNASARQRSRA 459

  Fly   251 VLGK--------FRIPFFMSQECEQLIRNMLVVEPDRRYTIKQI 286
            ...:        :|:..:.:...:|::.|.| ...::|::|.:|
Yeast   460 TSHRIARFDWRWYRLSDYKTNVGKQIVENTL-TRKNQRWSINEI 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	91/314 (29%)
		S_TKc	41..292	CDD:214567	91/313 (29%)
		UBA_SIK	335..380	CDD:270523
PRR1	NP_012806.1	S_TKc	192..508	CDD:214567	91/313 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810