Protein Alignment Sik3 and SIP3

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_194825.1
• Gene: SIP3 / 829221
• AraportID: AT4G30960
• Length: 441
• Species: Arabidopsis thaliana
• Alignment Length: 429
• Identity: 132/429 - (30%)
• Similarity: 218/429 - (50%)
• Gaps: 52/429 - (12%)

  Fly    39 GYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDK-TCLNEEYLNKTFREIAILKSLRHPHITR 102
            |.|||.:.:|.|.||.|..|.||.|...||:|::.| ..:....:::..|||::::.::||:|..
plant    22 GRYELGRLLGHGTFAKVYHARNIQTGKSVAMKVVGKEKVVKVGMVDQIKREISVMRMVKHPNIVE 86

  Fly   103 LYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAE 167
            |:|||.|:|.||...|....||:|.. ||.||::|..|...|.||:|||.:||.|||.|||||.|
plant    87 LHEVMASKSKIYFAMELVRGGELFAK-VAKGRLREDVARVYFQQLISAVDFCHSRGVYHRDLKPE 150

  Fly   168 NVLLDKDMNIKLADFG---FSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLY 229
            |:|||::.|:|:.|||   |:.|.::...|.|.||:|.|.||||.....|||.|:|:||.||:|:
plant   151 NLLLDEEGNLKVTDFGLSAFTEHLKQDGLLHTTCGTPAYVAPEVILKKGYDGAKADLWSCGVILF 215

  Fly   230 ALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSE 294
            .|:.|.|||....::.:..::..|.|:.|.::|.:..:|:..:|...|:.|.||::::...|..:
plant   216 VLLAGYLPFQDDNLVNMYRKIYRGDFKCPGWLSSDARRLVTKLLDPNPNTRITIEKVMDSPWFKK 280

  Fly   295 WQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHE 359
            ..:..:.:       |.:.|::.:...... ....|..:.:::...|::.|             .
plant   281 QATRSRNE-------PVAATITTTEEDVDF-LVHKSKEETETLNAFHIIAL-------------S 324

  Fly   360 QRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPV-------KQES 417
            :.||    :..|..:|.::.:||         :.::.||..|.....::.:..|       |.||
plant   325 EGFD----LSPLFEEKKKEEKRE---------MRFATSRPASSVISSLEEAARVGNKFDVRKSES 376

  Fly   418 LDRLSPLSNANASSSAL-----GFGWSDVAVDLEK-YGD 450
            ..|:....|......|:     ....|.|.|:::| :||
plant   377 RVRIEGKQNGRKGKLAVEAEIFAVAPSFVVVEVKKDHGD 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	103/255 (40%)
		UBA_SIK	335..380	CDD:270523	6/44 (14%)
SIP3	NP_194825.1	Protein Kinases, catalytic domain	23..277	CDD:473864	103/254 (41%)
		CIPK_C	316..432	CDD:213380	24/126 (19%)