Protein Alignment Sik3 and KIN11

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_566843.1
• Gene: KIN11 / 822566
• AraportID: AT3G29160
• Length: 512
• Species: Arabidopsis thaliana
• Alignment Length: 536
• Identity: 191/536 - (35%)
• Similarity: 269/536 - (50%)
• Gaps: 108/536 - (20%)

  Fly    41 YELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCL-NEEYLNKTFREIAILKSLRHPHITRLY 104
            |:|.||:|.|:|..||:|.::||..||||||:::..: |.|...|..|||.||:...||||.|.|
plant    20 YKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQY 84

  Fly   105 EVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENV 169
            ||:|:.|.||:|.||..:||:||::|..||::|.||...|.|::|.|.||||..|||||||.||:
plant    85 EVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENL 149

  Fly   170 LLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCG 234
            |||...|||:||||.||...:|..|||.||||.||||||..|..|.||:.|:||.||:||||:||
plant   150 LLDSRCNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCG 214

  Fly   235 ALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEM 299
            .||||.:.|..|..::..|.:.:|..:|.|...||..||:|:|.:|.||.:|.:|||   :|:.:
plant   215 TLPFDDENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVKRITIPEIRQHRW---FQTHL 276

  Fly   300 QEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDN 364
            ...                        .:.|||  |:|..              |:.::|   :.
plant   277 PRY------------------------LAVSPP--DTVEQ--------------AKKINE---EI 298

  Fly   365 IYAIYNLLHDKLQQRRRENQRLQHHASLAY-----SRSRKTSITTGVVDRSEPVKQESLDRLS-P 423
            :..:.|:..|:.|.......|.|:.|::.|     :|.|   :.:|.:   |...||:.|..| |
plant   299 VQEVVNMGFDRNQVLESLRNRTQNDATVTYYLLLDNRFR---VPSGYL---ESEFQETTDSGSNP 357

  Fly   424 LSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVN---AQHLSAHAGGGVNGANTRRH 485
            :....|.:|.:|. |....||  .||      |...:..||:   |..|.:||           |
plant   358 MRTPEAGASPVGH-WIPAHVD--HYG------LGARSQVPVDRKWALGLQSHA-----------H 402

  Fly   486 TVGPGDVAHE--QALANPNV-----PPIDFKC--PPQCSDPTQPVPYYPVNLPMLQNQPLH---- 537
               |.::.:|  :||...||     ...:.||  .|..:|...         .|:.|| ||
plant   403 ---PREIMNEVLKALQELNVCWKKIGHYNMKCRWVPGLADGQN---------TMVNNQ-LHFRDE 454

  Fly   538 NLTIKDQHLLKPPVVM 553
            :..|:|...:..|.|:
plant   455 SSIIEDDCAMTSPTVI 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	131/251 (52%)
		UBA_SIK	335..380	CDD:270523	7/44 (16%)
KIN11	NP_566843.1	STKc_AMPK_alpha	17..272	CDD:270981	132/254 (52%)
		UBA_SnRK1_plant	294..334	CDD:270520	8/42 (19%)
		AMPKA_C	391..509	CDD:213378	24/104 (23%)