DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik3 and Nuak2

DIOPT Version :10

Sequence 1:NP_611361.4 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:NP_001181954.1 Gene:Nuak2 / 74137 MGIID:1921387 Length:639 Species:Mus musculus


Alignment Length:716 Identity:196/716 - (27%)
Similarity:300/716 - (41%) Gaps:201/716 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 YELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEY-LNKTFREIAILKSLRHPHI---- 100
            ||..:|:|||.:..||.|.....:. ||||.|.|..:.:|. |....|||.|:.||.||||    
Mouse    57 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIH 120

  Fly   101 ----TRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVH 161
                :||..|.|:.|.|.:|.|||..|:::|::....|:.|.:|...|.|:|||:||||:.|:||
Mouse   121 EVGRSRLVTVFENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVH 185

  Fly   162 RDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGV 226
            ||||.||:|||.:.|||:||||.||.|.:|..|:|:||||.||:||:..|..|.||:.|.|||||
Mouse   186 RDLKLENILLDANGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGV 250

  Fly   227 VLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRW 291
            :||.||.|.:||||:....|..::..|.:|.|...|..| .|||.:|:|.|.||.|::.:..|.|
Mouse   251 LLYILVHGTMPFDGQDHKTLVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWW 314

  Fly   292 LSEW--QSEMQEQERFGDMSPGSGTVSKSASTSSLGSAS----DSPPQLDSVVMTHM----LQLP 346
            :: |  .:.:.|||...:....||...:::....|..:|    ::..::.|....|:    ..:|
Mouse   315 VN-WGYTTGVGEQEALREGGHPSGDFGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTVP 378

  Fly   347 GLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSE 411
            ||      :..|                .|::.|:||                            
Mouse   379 GL------ERQH----------------SLKKSRKEN---------------------------- 393

  Fly   412 PVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGG 476
                                        |:|.:|:             .||   |:..|:..|..
Mouse   394 ----------------------------DMAQNLQ-------------GDP---AEDTSSRPGKS 414

  Fly   477 ----VNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLH 537
                ..|...::.:...|:|..:.....| ||          ..|.||||  .|:|         
Mouse   415 SLKLPKGILKKKSSTSSGEVQEDPQELRP-VP----------DTPGQPVP--AVSL--------- 457

  Fly   538 NLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQ-GQQMDTAGYYINPNCGT 601
               :..:.:||.         .|:...|      ||.:.    .|:: |:.:|.:..:::    .
Mouse   458 ---LPRKGILKK---------SRQRESG------YYSSP----EPSESGELLDASDVFVS----G 496

  Fly   602 DPLAVQELSP------LNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAH 660
            ||  |::.||      |:.:.:.::       .|:.:.....      ||...|.|..:.|:.:|
Mouse   497 DP--VEQKSPQASGLLLHRKGILKL-------NGKFSRTALE------GTTPSTFGSLDQLASSH 546

  Fly   661 GSGAGSQ-SQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPN 724
            .:...|: |.|.:..|.:.......|.:.||.|..|......|::          |:.|.|.|..
Mouse   547 PAARPSRPSGAVSEDSILSSESFDQLDLPERLPETPLRGCVSVDN----------LRGLEQPPSE 601

  Fly   725 G 725
            |
Mouse   602 G 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_611361.4 Protein Kinases, catalytic domain 40..292 CDD:473864 119/259 (46%)
UBA_SIK 335..380 CDD:270523 7/48 (15%)
Nuak2NP_001181954.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Protein Kinases, catalytic domain 53..315 CDD:473864 119/259 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..485 36/250 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..575 11/51 (22%)
Blue background indicates that the domain is not in the aligned region.

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