DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and Sik3

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_081774.3	Gene:	Sik3 / 70661	MGIID:	2446296	Length:	1369	Species:	Mus musculus

Alignment Length:	1673	Identity:	464/1673 - (27%)
Similarity:	646/1673 - (38%)	Gaps:	593/1673 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PTAGPAAAP---PTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTK 66
            |.|||.|||   |.::.|.....|: |:.|:  ..|:||||:::|||||||||||.||::|||.|
Mouse    30 PAAGPPAAPAAVPPAAVPARPTAPA-SRGSM--AARIGYYEIDRTIGKGNFAVVKRATHLVTKAK 91

  Fly    67 VAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVA 131
            ||||||||:.|:||.|.|.|||:.|:|.|.||||.|||:|||::.|||||||||..|||||||||
Mouse    92 VAIKIIDKSQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVA 156

  Fly   132 NGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKT 196
            :|||.|.||.|.|.|:|:||::||.|.:|||||||||:|||.::|||:|||||||.:..|..|||
Mouse   157 HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKT 221

  Fly   197 WCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFM 261
            |||||||||||:|:|.||||||.||||||||||.||||||||||.|:..|::||:.|||||||||
Mouse   222 WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFM 286

  Fly   262 SQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGS 326
            |.|||.|||:|||::|::|.:::||.:|:|:           :.||..|....:  .|....|..
Mouse   287 STECEHLIRHMLVLDPNKRLSMEQICRHKWM-----------KLGDADPNFDRL--IAECQQLKE 338

  Fly   327 ASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHAS 391
            ...|.|..|.|::.  ::..||..:...||:....:|:..|||:||.|    |.::::.|:..|.
Mouse   339 ERQSDPLNDDVLLA--MEDMGLDKERTLQSLRSDAYDHYSAIYSLLCD----RHKKHKTLRPGAL 397

  Fly   392 LAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECL 456
                                |...:::...:|: |..|..:......|...|.|....:..:|
Mouse   398 --------------------PSMPQAMTFQAPV-NLQAEQTGTAMNLSVPQVQLINPENQIIE-- 439

  Fly   457 ARSNDPPVNAQHLSAHAG------GGVNGANTRRHTVGPGDVAHE-----QALANPNVPPIDFKC 510
                  |..|.:|.:..|      ..|...:.||||||..|...|     |.|. |..|.:
Mouse   440 ------PDGAVNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLL-PGFPGV---- 493

  Fly   511 PPQCSDPTQPVPYYPVN-------LPMLQNQPLHNLTIKDQHLLKPPVVM---GASSFGRRASDG 565
                 :|..|......|       |||...||...|..|:|.||:||.:.   |....|||||||
Mouse   494 -----NPQGPFLQVAPNMNFTHNLLPMQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDG 553

  Fly   566 GANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPL-----AVQELSPLNEQSVAQMQCCQE 625
            |||:.::            .||:      :....|..||     ||..::|::|          |
Mouse   554 GANIQLH------------AQQL------LKRPRGPSPLVTMTPAVPAVTPVDE----------E 590

  Fly   626 NATGECNEE-LQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTE 689
            ::.||.::| :|.|:..|  ::|||:..|                :||..
Mouse   591 SSDGEPDQEAVQRYLANR--SKRHTLAMT----------------SPTAE--------------- 622

  Fly   690 RPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAG 754
                |||::.|::..:..|                              ..:.|||
Mouse   623 ----IPPDLQRQLGQQSFR------------------------------SRVWPPH--------- 644

  Fly   755 GSVPLVAPNNRRIHR---VVHSKLPTVQEGATIGRYSPVRRASEGSKS--QFQGPL--------- 805
                ||...:|..::   .:|  |||       .|:|||||.|:|:.|  .|:..|
Mouse   645 ----LVPDQHRSTYKDSNTLH--LPT-------ERFSPVRRFSDGAASIQAFKAHLEKMGNSSSI 696

  Fly   806 ----QECQSLQK------------GIAQRNFLV--------------------APSPPL---LEN 831
                |||:.|||            ...|::.|.                    .|||||   .||
Mouse   697 KQLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQVACEN 761

  Fly   832 SISL-----------PGSPIHGKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEI 885
            ..:|           |.||....|.         .|....|    .|..|             .:
Mouse   762 QPALLTHQLQRLRIQPSSPPPNHPS---------NHLFRQP----SNSPP-------------PV 800

  Fly   886 ANKIISTHVVPMDLAPLLGLAAHAS-------------SAAAVSGGHLDQSHFTHLQQQQQQQHM 937
            ::.:|::|..... :...||.:|.:             |.|....|         |||..|.|.:
Mouse   801 SSAMITSHGATSP-SQFQGLPSHGAIFQQQPENCSPPPSVALTCLG---------LQQASQSQPV 855

  Fly   938 LSFSVSPLSMPQGGAVNASLTSAKQMFGQPICGYTQYQPMTLALQPQHQQQLVGQFS-------- 994
            ......|:.|....|..|:.::.:.:   ||      .|....:|.||:..|:..||
Mouse   856 TIQLQEPVDMLSNMAGTAAGSAGRSI---PI------SPSASQIQIQHRASLMAPFSYGHRPLSK 911

  Fly   995 ----------SINLGA-SNSNSSSGCQSP-VFSTSFSGSCSPNPYLPGAAGGSSPLHQITKGISG 1047
                      |:|:.. |.:|.......| :||....|  ||:.|.|....|..|
Mouse   912 QLSADSAEAHSLNMNRFSPANYDQAHLHPHLFSDQSRG--SPSSYSPSTGVGFPP---------- 964

  Fly  1048 LSTGCAGGSITRGTSAASEGAAAAAAANQPLDLSMDVCGGVMDQQPTDYAATNWFMPTASYYDMK 1112
                                  ..|....||           ||.||       |.|:|   ..:
Mouse   965 ----------------------TQALKVPPL-----------DQFPT-------FPPSA---QQQ 986

  Fly  1113 P--LNLSPAQPVRVVPTPPASPNLCIIQEENGNGQMCHTISTGTPYAGCTGGITPQICLT---DV 1172
            |  ...|..|...:.||||..|.         :.|:.|.:.         |.::|:..||   |:
Mouse   987 PPHYTTSALQQALLSPTPPDYPR---------HQQVPHILQ---------GLLSPRHSLTGHSDI 1033

  Fly  1173 --------------------------------------QGSEITLV------------ALSSDNS 1187
                                                  ||..::|.            |||..|:
Mouse  1034 RLPPAEFAQLIKRQQQHRQQQQQQQQQQEYHELFRHMNQGDAVSLAPSLGGQNMTEQQALSYQNA 1098

  Fly  1188 RDS----------------EDSLEQ-----------HTPVMS----------LQGLIITEPSSDM 1215
             ||                :|.:.|           |.|.:.          .:||....|....
Mouse  1099 -DSYHRHHTSPQHILQIRAQDCISQGPSPTPTHGYAHQPPLMHSESMEEDCLCEGLKEGFPDKSS 1162

  Fly  1216 PSITRGIGRKASLDCDSGAGSHCPVASGSSHANQ-------SQTQAQTEAQCRRGSDKSLGFSDD 1273
            .::|:|......|.|.||.|...|:....|.|.:       .|..|.|             ||.:
Mouse  1163 STLTKGCHNSPLLLCTSGPGDPEPLLGTVSQARELGIHPYGHQPTATT-------------FSRN 1214

  Fly  1274 SLSNDSNNLSPCQEPSASSGFKSDSHSEMGDHTECGHLTPDSMCD---SRRMSDEMCYEVPLPHE 1335
            .:.:..:.|..|.|.|:..     ...|:.||...|:.....:.:   ||.:...        |.
Mouse  1215 KVPSRESVLGNCLERSSPG-----QAMELPDHNGLGYPVRPLVSEHLRSRTLQRH--------HT 1266

  Fly  1336 CSNLDSTRILEMVKQTIDSTMPPKGFVLHKGSISSEDSGAESRHSSASNA--------------- 1385
            ..|.|...:      .:| |:|....|..|...|:..|.|....||...:
Mouse  1267 IQNSDDAYV------QLD-TLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDEEDEECGVSL 1324

  Fly  1386 ---------------STSNPLACEAASLLASHSGYGEPTTNLSLEYSG 1418
                           |:..|..| ...::.||.   .|..:.|:|.:|
Mouse  1325 GHEHPGLGDGSQHLNSSRYPATC-VTDIMLSHK---HPEVSFSMEQAG 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	175/251 (70%)
		S_TKc	41..292	CDD:214567	174/250 (70%)
		UBA_SIK	335..380	CDD:270523	13/44 (30%)
Sik3	NP_081774.3	STKc_SIK	65..317	CDD:270973	175/251 (70%)
		S_TKc	66..317	CDD:214567	174/250 (70%)
		UBA_SIK3	346..390	CDD:270593	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106016
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740