Protein Alignment Sik3 and Gm7168

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_006524826.1
• Gene: Gm7168 / 635895
• MGIID: 3643198
• Length: 549
• Species: Mus musculus
• Alignment Length: 558
• Identity: 153/558 - (27%)
• Similarity: 240/558 - (43%)
• Gaps: 131/558 - (23%)

  Fly    13 PPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCL 77
            ||.|..|.|   |...::       ...|::.:|:|.|.:|.|.||.:.:|.|.||:|::.|
Mouse    51 PPPSPQPSN---PEDGEL-------YSQYKVVRTLGHGTYAKVLLAKHWLTGTPVAVKVLLK--- 102

  Fly    78 NEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAAR 142
            |:.......:|..|:|.::||:|..|.:|.|:::..||:.|.....|:::::.::|.::|.||.:
Mouse   103 NKPCFQPAMKEANIMKKIKHPNIVSLLQVFETKTRGYLIMELVEGQELYEYIKSSGHIEEDEARQ 167

  Fly   143 VFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPE 207
            :|.|::|||.|||..|:||||||.:|:::|...:||:.|||.|...:.|..|...||:..:.|||
Mouse   168 IFLQILSAVSYCHGLGIVHRDLKPDNIMIDDKGSIKIIDFGLSTQVKPGDLLDEHCGAYAFGAPE 232

  Fly   208 VFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNM 272
            :|....|||.|||:|:|||:||.:|.|.:|||...|.||:.:::.|.:..|..:|.|.:.|:..:
Mouse   233 LFLWKSYDGTKSDLWALGVILYYMVVGKVPFDSYIIPELQRQILAGVYPAPCGVSNELKDLLSLL 297

  Fly   273 LVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSP----PQ 333
            :.|.|..|.|:.:::||.||                         ......|.:..:.|    |.
Mouse   298 MTVNPKYRPTVTEVMKHPWL-------------------------RGHCKGLTNIHEEPVPVRPD 337

  Fly   334 LDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSR 398
            .|.|   ..:|..|..|..|.:|:.:::|:.:.|.|.||         |.|.||...       |
Mouse   338 PDIV---DAMQYIGFQAKDIRESLTKEKFNEMSAAYYLL---------EEQALQREV-------R 383

  Fly   399 KTSITTGVVDRSEPVKQESLDRLSPLS-NANASSSALGFGWSDVAVDLEKYGDFELECLARSNDP 462
            .|...| |.....|.........|.|. ..:.|:|.||......::|.|
Mouse   384 STQAPT-VSQVKAPFPSMDAGEASCLKIKRSGSASILGRSVWPPSIDQE---------------- 431

  Fly   463 PVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVN 527
            |...|.:...||         |.:.|.|      .|..||.           ..|||
Mouse   432 PAYVQKVRQRAG---------RRSSGHG------LLFEPNQ-----------MTPTQ-------- 462

  Fly   528 LPMLQNQPLHNLTIKDQHLLKP---PVVMGASSFGRRA 562
                           |||.::.   |.::..||....:
Mouse   463 ---------------DQHHIRAMSVPCMLSTSSISEES 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	94/251 (37%)
		S_TKc	41..292	CDD:214567	94/250 (38%)
		UBA_SIK	335..380	CDD:270523	12/44 (27%)
Gm7168	XP_006524826.1	STKc_AMPK-like	68..316	CDD:270905	94/250 (38%)
		UBA_MARK_Par1	336..375	CDD:270522	13/50 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810