DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik3 and Mark2

DIOPT Version :9

Sequence 1:NP_001188969.1 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:XP_006230941.1 Gene:Mark2 / 60328 RGDID:708483 Length:841 Species:Rattus norvegicus


Alignment Length:801 Identity:263/801 - (32%)
Similarity:363/801 - (45%) Gaps:183/801 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 PTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAI 69
            ||.|...:.|:|.:  |......|..|.|:...:|.|.|.|||||||||.||||.:|:|..:||:
  Rat    19 PTLGHLDSKPSSKS--NMLRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAV 81

  Fly    70 KIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGR 134
            ||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:|||:||
  Rat    82 KIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR 146

  Fly   135 MKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCG 199
            |||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|:||
  Rat   147 MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCG 211

  Fly   200 SPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQE 264
            ||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||.:
  Rat   212 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 276

  Fly   265 CEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASD 329
            ||.|::..|::.|.:|.|::||:|.||::....:                       ..|....:
  Rat   277 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED-----------------------DELKPYVE 318

  Fly   330 SPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAY 394
            ..|.......|.::...|.|.:.|..|:..||::.:.|.|.||..|..:...:...|:...|...
  Rat   319 PLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADL 383

  Fly   395 SRSRKTSITTGVVDRS---EPVKQESLDRLSP-LSNANASSSALGFGWSDVAVDLEKYGDFELEC 455
            :.|...| .:..|.||   .|.::.|.|:..| :..:|:.|..                      
  Rat   384 TNSSAPS-PSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKK---------------------- 425

  Fly   456 LARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQP 520
             .:||    ||::.......|...::|.:....|             :|.:|.|       .|.|
  Rat   426 -TQSN----NAENKRPEEETGRKASSTAKVPASP-------------LPGLDRK-------KTTP 465

  Fly   521 VP----------YYPVNLPMLQNQPLHNLTIKD--QHLLKPPVVMGASSFGRRASDGGANLHIYY 573
            .|          ....|.|:|....|...:|::  ..|..|         |.|||...|:     
  Rat   466 TPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSLTMP---------GSRASTASAS----- 516

  Fly   574 PATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSY 638
             |..:...|.|.|:..:|..:.|...|..|.                         |.|.|:   
  Rat   517 -AAVSAARPRQHQKSMSASVHPNKASGLPPT-------------------------ESNCEV--- 552

  Fly   639 MQKRGGT--QRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIRE 701
              .|..|  ||..|......:::..|||..::..|...|:......|.|                
  Rat   553 --PRPSTAPQRVPVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQL---------------- 599

  Fly   702 VESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGGSV------PLV 760
               |..||         .|:.|.|..|   |.|.|.|:|.         ..|.||:      ..|
  Rat   600 ---RQVRD---------QQNLPFGVTP---ASPSGHSQGR---------RGASGSIFSKFTSKFV 640

  Fly   761 APN-NRRIHRVVHSKLPTVQE 780
            ..| :.|..|.....||..||
  Rat   641 RRNLSFRFARRCRLSLPKSQE 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_001188969.1 PKc_like 40..292 CDD:304357 154/251 (61%)
S_TKc 41..292 CDD:214567 154/250 (62%)
UBA_SIK 335..380 CDD:270523 12/44 (27%)
Mark2XP_006230941.1 STKc_MARK 52..304 CDD:270974 154/251 (61%)
S_TKc 53..304 CDD:214567 154/250 (62%)
UBA_MARK2 322..363 CDD:270589 11/40 (28%)
MARK2_C 742..840 CDD:213386
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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