DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and mark2

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_012808991.1	Gene:	mark2 / 594939	XenbaseID:	XB-GENE-876451	Length:	792	Species:	Xenopus tropicalis

Alignment Length:	795	Identity:	262/795 - (32%)
Similarity:	369/795 - (46%)	Gaps:	174/795 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATTPTAGPA---AAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIV 62
            :|..|..|.|   .:...||.|...:..::...:.|:...:|.|.|.|||||||||.||||.:::
Frog    21 LAHEPALGHADQKTSSSGSSKPNMLRCRTSIATTADEQPHIGNYRLLKTIGKGNFAKVKLARHVL 85

  Fly    63 TKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFD 127
            |..:||:||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||
Frog    86 TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFD 150

  Fly   128 HLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGA 192
            :|||:|||||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|.
Frog   151 YLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAENLLLDSDMNIKIADFGFSNEFTFGN 215

  Fly   193 TLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRI 257
            .|.|:||||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||
Frog   216 KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRI 280

  Fly   258 PFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTS 322
            ||:||.:||.|::..|::.|.:|.|::||::.||::....|       .::.|....:
Frog   281 PFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGHEE-------DELKPYVEPI------- 331

  Fly   323 SLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQ 387
                     |.......|.::...|.|.:.|:.|:..|:::.:.|.|.||..|..:...:|..|:
Frog   332 ---------PDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLLLGYKSSETDNDNLTLK 387

  Fly   388 HHA------SLAYSRSRKTSITTGVVDRS---EPVKQESLDRLSP-LSNANASSSALGFGWSDVA 442
            ...      |:|.|.:.|       |.||   .|.::...|:..| :.|:|:.|..
Frog   388 PRPPPDVTNSIAPSPAHK-------VQRSVSANPKQRRLSDQAGPAIPNSNSYSKK--------- 436

  Fly   443 VDLEKYGDFELECLARSNDPPVNAQHLSAH--AGGGVNGANTRRHTVGPGDVAHEQALANPNVPP 505
                          .:||    ||::..:.  ...|...::|.|                  |||
Frog   437 --------------TQSN----NAENRRSEDDKESGRKSSSTVR------------------VPP 465

  Fly   506 -----IDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSF---GRRA 562
                 :|.|       .|.|.|.....|....|:..::..:....|:...|..|..||   |.||
Frog   466 SPLSGLDRK-------KTTPTPSTNSVLSTGTNRSRNSPMLDRASLVPGSVQNGKDSFSTPGSRA 523

  Fly   563 SDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINP------NC-----GTDPLAVQELSPLNEQS 616
            |...|      |||...:...| :.|.|:.:...|      ||     .|.|..|...||
Frog   524 STASA------PATSARIRQHQ-KSMSTSVHPSKPAPSLDGNCEVQRPSTAPQRVPVASP----- 576

  Fly   617 VAQMQCCQENATGECNEELQSYMQKRGGTQRHT--VGCTEDLSVAHGSGAGSQSQA-PTTSSNMR 678
                  ...|.:....|....   .||.:.|.|  .|...........|.||.|.| |:.:|..|
Frog   577 ------SAHNISSAATERTNF---PRGVSSRSTFHAGQVRQARDQQNLGFGSVSPASPSGNSQGR 632

  Fly   679 QRRTGLL---------------TVTERPPVIP----------PEII---REVESRMKRDYLPPTL 715
            :..||.:               ....|.|..|          |.:.   :|.:....||..|.:|
Frog   633 RGATGSIFSKFTSKFVRRNLSFRFPRRNPNEPEGKDRVESTRPHLTVLDKEKDKEDHRDSKPRSL 697

  Fly   716 ------KSLSQSPPN 724
                  |:.|...||
Frog   698 RFTWSMKTTSSMEPN 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	152/251 (61%)
		S_TKc	41..292	CDD:214567	152/250 (61%)
		UBA_SIK	335..380	CDD:270523	11/44 (25%)
mark2	XP_012808991.1	STKc_MARK	63..315	CDD:270974	152/251 (61%)
		UBA_MARK2	333..374	CDD:270589	10/40 (25%)
		MARK2_C	693..791	CDD:213386	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910