Protein Alignment Sik3 and mark2

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_012808991.1
• Gene: mark2 / 594939
• XenbaseID: XB-GENE-876451
• Length: 792
• Species: Xenopus tropicalis
• Alignment Length: 795
• Identity: 262/795 - (32%)
• Similarity: 369/795 - (46%)
• Gaps: 174/795 - (21%)

  Fly     1 MATTPTAGPA---AAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIV 62
            :|..|..|.|   .:...||.|...:..::...:.|:...:|.|.|.|||||||||.||||.:::
 Frog    21 LAHEPALGHADQKTSSSGSSKPNMLRCRTSIATTADEQPHIGNYRLLKTIGKGNFAKVKLARHVL 85

  Fly    63 TKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFD 127
            |..:||:||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||
 Frog    86 TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFD 150

  Fly   128 HLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGA 192
            :|||:|||||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|.
 Frog   151 YLVAHGRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAENLLLDSDMNIKIADFGFSNEFTFGN 215

  Fly   193 TLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRI 257
            .|.|:||||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||
 Frog   216 KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRI 280

  Fly   258 PFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTS 322
            ||:||.:||.|::..|::.|.:|.|::||::.||::....|       .::.|....:
 Frog   281 PFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGHEE-------DELKPYVEPI------- 331

  Fly   323 SLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQ 387
                     |.......|.::...|.|.:.|:.|:..|:::.:.|.|.||..|..:...:|..|:
 Frog   332 ---------PDYKDPKRTELMITMGYTREEISDSLVNQKYNEVMATYLLLGYKSSETDNDNLTLK 387

  Fly   388 HHA------SLAYSRSRKTSITTGVVDRS---EPVKQESLDRLSP-LSNANASSSALGFGWSDVA 442
            ...      |:|.|.:.|       |.||   .|.::...|:..| :.|:|:.|..
 Frog   388 PRPPPDVTNSIAPSPAHK-------VQRSVSANPKQRRLSDQAGPAIPNSNSYSKK--------- 436

  Fly   443 VDLEKYGDFELECLARSNDPPVNAQHLSAH--AGGGVNGANTRRHTVGPGDVAHEQALANPNVPP 505
                          .:||    ||::..:.  ...|...::|.|                  |||
 Frog   437 --------------TQSN----NAENRRSEDDKESGRKSSSTVR------------------VPP 465

  Fly   506 -----IDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSF---GRRA 562
                 :|.|       .|.|.|.....|....|:..::..:....|:...|..|..||   |.||
 Frog   466 SPLSGLDRK-------KTTPTPSTNSVLSTGTNRSRNSPMLDRASLVPGSVQNGKDSFSTPGSRA 523

  Fly   563 SDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINP------NC-----GTDPLAVQELSPLNEQS 616
            |...|      |||...:...| :.|.|:.:...|      ||     .|.|..|...||
 Frog   524 STASA------PATSARIRQHQ-KSMSTSVHPSKPAPSLDGNCEVQRPSTAPQRVPVASP----- 576

  Fly   617 VAQMQCCQENATGECNEELQSYMQKRGGTQRHT--VGCTEDLSVAHGSGAGSQSQA-PTTSSNMR 678
                  ...|.:....|....   .||.:.|.|  .|...........|.||.|.| |:.:|..|
 Frog   577 ------SAHNISSAATERTNF---PRGVSSRSTFHAGQVRQARDQQNLGFGSVSPASPSGNSQGR 632

  Fly   679 QRRTGLL---------------TVTERPPVIP----------PEII---REVESRMKRDYLPPTL 715
            :..||.:               ....|.|..|          |.:.   :|.:....||..|.:|
 Frog   633 RGATGSIFSKFTSKFVRRNLSFRFPRRNPNEPEGKDRVESTRPHLTVLDKEKDKEDHRDSKPRSL 697

  Fly   716 ------KSLSQSPPN 724
                  |:.|...||
 Frog   698 RFTWSMKTTSSMEPN 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	152/251 (61%)
		UBA_SIK	335..380	CDD:270523	11/44 (25%)
mark2	XP_012808991.1	STKc_MARK	63..315	CDD:270974	152/251 (61%)
		UBA_MARK2	333..374	CDD:270589	10/40 (25%)
		MARK2_C	693..791	CDD:213386	6/20 (30%)