Protein Alignment Sik3 and Sik1

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_067725.2
• Gene: Sik1 / 59329
• RGDID: 69407
• Length: 776
• Species: Rattus norvegicus
• Alignment Length: 1005
• Identity: 306/1005 - (30%)
• Similarity: 437/1005 - (43%)
• Gaps: 311/1005 - (30%)

  Fly    24 VPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFRE 88
            ||:.:.....|.||||:|::|:|:|||||||||||.:.||||:|||||||||.|:...|.|.:||
  Rat    10 VPTGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYRE 74

  Fly    89 IAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHY 153
            :.::|.|.||:|.:||:|||::.|:|:|||:|.|||:||:|.:||.:.|.||.:.|.|::|||.|
  Rat    75 VQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEY 139

  Fly   154 CHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPK 218
            ||...:||||||.||:|||.:|:||||||||.|.|:.|..|.||||||||||||||:|.||:||:
  Rat   140 CHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQ 204

  Fly   219 SDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTI 283
            .||||||||||.||||:|||||..:..|:.||:.|:|||||||||:||.|||.||||:|.:|.||
  Rat   205 LDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITI 269

  Fly   284 KQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGL 348
            .||.:|||:....:.:|:.:         ...|....||:||..::.        :..::|..|:
  Rat   270 AQIRQHRWMQADPTLLQQDD---------PAFSMQGYTSNLGDYNEQ--------VLGIMQALGI 317

  Fly   349 TADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPV 413
            ......:|:....:::..|||.||.::|:         :|.::...||:...           |.
  Rat   318 DRQRTVESLQNSSYNHFAAIYYLLLERLR---------EHRSTQPSSRATPA-----------PA 362

  Fly   414 KQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVN 478
            :|..|                                       |::|
  Rat   363 RQPQL---------------------------------------RNSD----------------- 371

  Fly   479 GANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKD 543
                               |::..||.....|     ||.:|....|      |.|.|      .
  Rat   372 -------------------LSSLEVPQEILPC-----DPFRPSLLCP------QPQAL------A 400

  Fly   544 QHLLKPPVVMGASSFGRRASDGGANLH-----IYYPATGTVVGPAQGQQMDTAGYYINPNCGTDP 603
            |.:|:..:              ..:||     :::|             :||       || :..
  Rat   401 QSVLQAEI--------------DCDLHSSLQPLFFP-------------LDT-------NC-SGV 430

  Fly   604 LAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGT--QRHTVGCTEDLSVAHGSGAGS 666
            ...:.:||   .|:......:|...|...||.|...:...|:  :|||:.   ::|
  Rat   431 FRHRSISP---SSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLA---EVS--------- 480

  Fly   667 QSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGT----- 726
                                 |...|:.||.||  |.|            |.:.||..||
  Rat   481 ---------------------THFSPLNPPCII--VSS------------SAAVSPSEGTSSDSC 510

  Fly   727 YPVGAAL-PMGMSKGLSPPHSLPLVAAAGGSVP--LVAPNNRRIHRVVHSKLPTVQEGATIGR-- 786
            .|..|:. |.|:..||:.|..|      |.|.|  |.:|     .....|..|.:|..|.:|.
  Rat   511 LPFSASEGPAGLGGGLATPGLL------GTSSPVRLASP-----FLGSQSATPVLQSQAGLGATV 564

  Fly   787 YSPV-----RRASEGSKSQ----FQGPLQECQSLQKGIAQRNFLVAPSPPLLENSI--SLPG-SP 839
            ..||     ||||:.|.:|    |:..|:: .:..||....|.:...:..:.::||  |..| |.
  Rat   565 LPPVSFQEGRRASDTSLTQGLKAFRQQLRK-NARTKGFLGLNKIKGLARQVCQSSIRGSRGGMST 628

  Fly   840 IH-GKPGMGLQ---LALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEIANKIISTHV------ 894
            .| ..|..|||   .:.|.|..:             |:.::.:||:.....:..:|:..
  Rat   629 FHTPAPSSGLQGCTASSREGRSL-------------LEEVLHQQRLLQLQHHSAVSSDYQQAPQL 680

  Fly   895 --VPMDLAPLLGL----------------AAHASSAAAVSGGHLDQSHFTHLQ---------QQQ 932
              ||..|.|..||                .:..:|||.:...||      |:.         ...
  Rat   681 SPVPYVLTPCDGLLVSGIPLLPTPLLQPGMSPVASAAQLLDAHL------HISAGPVALPTGPLP 739

  Fly   933 QQQHMLSFSVSPLSMPQGGAVNASLTSAKQ 962
            |....||.|..|..:|||......|||.::
  Rat   740 QCLTRLSPSCDPAGLPQGDCEMEDLTSGQR 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	159/251 (63%)
		UBA_SIK	335..380	CDD:270523	9/44 (20%)
Sik1	NP_067725.2	STKc_SIK	26..278	CDD:270973	159/251 (63%)
		UBA_SIK1	300..349	CDD:270591	11/65 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..371		6/70 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472		6/22 (27%)
		RK-rich region. /evidence=ECO:0000250	586..612		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..643		8/21 (38%)