DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik3 and Sik1

DIOPT Version :9

Sequence 1:NP_001188969.1 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:NP_067725.2 Gene:Sik1 / 59329 RGDID:69407 Length:776 Species:Rattus norvegicus


Alignment Length:1005 Identity:306/1005 - (30%)
Similarity:437/1005 - (43%) Gaps:311/1005 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 VPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFRE 88
            ||:.:.....|.||||:|::|:|:|||||||||||.:.||||:|||||||||.|:...|.|.:||
  Rat    10 VPTGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYRE 74

  Fly    89 IAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHY 153
            :.::|.|.||:|.:||:|||::.|:|:|||:|.|||:||:|.:||.:.|.||.:.|.|::|||.|
  Rat    75 VQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEY 139

  Fly   154 CHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPK 218
            ||...:||||||.||:|||.:|:||||||||.|.|:.|..|.||||||||||||||:|.||:||:
  Rat   140 CHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQ 204

  Fly   219 SDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTI 283
            .||||||||||.||||:|||||..:..|:.||:.|:|||||||||:||.|||.||||:|.:|.||
  Rat   205 LDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITI 269

  Fly   284 KQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGL 348
            .||.:|||:....:.:|:.:         ...|....||:||..::.        :..::|..|:
  Rat   270 AQIRQHRWMQADPTLLQQDD---------PAFSMQGYTSNLGDYNEQ--------VLGIMQALGI 317

  Fly   349 TADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPV 413
            ......:|:....:::..|||.||.::|:         :|.::...||:...           |.
  Rat   318 DRQRTVESLQNSSYNHFAAIYYLLLERLR---------EHRSTQPSSRATPA-----------PA 362

  Fly   414 KQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVN 478
            :|..|                                       |::|                 
  Rat   363 RQPQL---------------------------------------RNSD----------------- 371

  Fly   479 GANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKD 543
                               |::..||.....|     ||.:|....|      |.|.|      .
  Rat   372 -------------------LSSLEVPQEILPC-----DPFRPSLLCP------QPQAL------A 400

  Fly   544 QHLLKPPVVMGASSFGRRASDGGANLH-----IYYPATGTVVGPAQGQQMDTAGYYINPNCGTDP 603
            |.:|:..:              ..:||     :::|             :||       || :..
  Rat   401 QSVLQAEI--------------DCDLHSSLQPLFFP-------------LDT-------NC-SGV 430

  Fly   604 LAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGT--QRHTVGCTEDLSVAHGSGAGS 666
            ...:.:||   .|:......:|...|...||.|...:...|:  :|||:.   ::|         
  Rat   431 FRHRSISP---SSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLA---EVS--------- 480

  Fly   667 QSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGT----- 726
                                 |...|:.||.||  |.|            |.:.||..||     
  Rat   481 ---------------------THFSPLNPPCII--VSS------------SAAVSPSEGTSSDSC 510

  Fly   727 YPVGAAL-PMGMSKGLSPPHSLPLVAAAGGSVP--LVAPNNRRIHRVVHSKLPTVQEGATIGR-- 786
            .|..|:. |.|:..||:.|..|      |.|.|  |.:|     .....|..|.:|..|.:|.  
  Rat   511 LPFSASEGPAGLGGGLATPGLL------GTSSPVRLASP-----FLGSQSATPVLQSQAGLGATV 564

  Fly   787 YSPV-----RRASEGSKSQ----FQGPLQECQSLQKGIAQRNFLVAPSPPLLENSI--SLPG-SP 839
            ..||     ||||:.|.:|    |:..|:: .:..||....|.:...:..:.::||  |..| |.
  Rat   565 LPPVSFQEGRRASDTSLTQGLKAFRQQLRK-NARTKGFLGLNKIKGLARQVCQSSIRGSRGGMST 628

  Fly   840 IH-GKPGMGLQ---LALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEIANKIISTHV------ 894
            .| ..|..|||   .:.|.|..:             |:.::.:||:.....:..:|:..      
  Rat   629 FHTPAPSSGLQGCTASSREGRSL-------------LEEVLHQQRLLQLQHHSAVSSDYQQAPQL 680

  Fly   895 --VPMDLAPLLGL----------------AAHASSAAAVSGGHLDQSHFTHLQ---------QQQ 932
              ||..|.|..||                .:..:|||.:...||      |:.         ...
  Rat   681 SPVPYVLTPCDGLLVSGIPLLPTPLLQPGMSPVASAAQLLDAHL------HISAGPVALPTGPLP 739

  Fly   933 QQQHMLSFSVSPLSMPQGGAVNASLTSAKQ 962
            |....||.|..|..:|||......|||.::
  Rat   740 QCLTRLSPSCDPAGLPQGDCEMEDLTSGQR 769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_001188969.1 PKc_like 40..292 CDD:304357 159/251 (63%)
S_TKc 41..292 CDD:214567 159/250 (64%)
UBA_SIK 335..380 CDD:270523 9/44 (20%)
Sik1NP_067725.2 STKc_SIK 26..278 CDD:270973 159/251 (63%)
UBA_SIK1 300..349 CDD:270591 11/65 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..371 6/70 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..472 6/22 (27%)
RK-rich region. /evidence=ECO:0000250 586..612 5/26 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..643 8/21 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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