DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and MARK4

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_001186796.1	Gene:	MARK4 / 57787	HGNCID:	13538	Length:	752	Species:	Homo sapiens

Alignment Length:	834	Identity:	266/834 - (31%)
Similarity:	367/834 - (44%)	Gaps:	250/834 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KVPSTSKISVDKLLR------------VGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKT 75
            |.||.|..|:....|            ||.|.|.:||||||||.||||.:|:|..:|||||||||
Human    29 KGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKT 93

  Fly    76 CLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEA 140
            .||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:||::|||||.||
Human    94 QLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEA 158

  Fly   141 ARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAA 205
            ...|.|:||||||||::.:|||||||||:|||.:.|||:|||||||.:..|:.|.|:||||||||
Human   159 RAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAA 223

  Fly   206 PEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIR 270
            ||:|||.:||||:.|||||||:||.||.|:|||||..:.||:.||:.||:|:||:||.:||.::|
Human   224 PELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILR 288

  Fly   271 NMLVVEPDRRYTIKQIIKHRWLS------EWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASD 329
            ..||:.|.:|.|::||:|.:|::      |.:...:.:|.|||             |..:
Human   289 RFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGD-------------TKRI----- 335

  Fly   330 SPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAY 394
                   .||..|    |.|.:.|.:|:..|:::.:.|.|.||     .|:.|....:....||.
Human   336 -------EVMVGM----GYTREEIKESLTSQKYNEVTATYLLL-----GRKTEEGGDRGAPGLAL 384

  Fly   395 SRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARS 459
            :|.|..|.||                       |.:||:.|
Human   385 ARVRAPSDTT-----------------------NGTSSSKG------------------------ 402

  Fly   460 NDPPVNAQHLSAHAGGGVNGANT----RRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQP 520
                      ::|:.|..:.::|    |||:                    || |.|      .|
Human   403 ----------TSHSKGQRSSSSTYHRQRRHS--------------------DF-CGP------SP 430

  Fly   521 VPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRAS-----DGGANLHIYYPATGTVV 580
            .|.:|...|....:    ..:|::.|   |        ||:||     .|...|    |.:..:|
Human   431 APLHPKRSPTSTGE----AELKEERL---P--------GRKASCSTAGSGSRGL----PPSSPMV 476

  Fly   581 GPAQGQQMDTAGYYINPNCG------TDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYM 639
            ..|.           |||..      .|..:.....|.:..:......|.|....|....|.:..
Human   477 SSAH-----------NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGK 530

  Fly   640 QKRGGTQR--------HTV----------------------GCTEDLSVAHGSGAGSQSQAPTT- 673
            :...||.|        |::                      |...|.....|.|.|.|:..|.:
Human   531 ENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASP 595

  Fly   674 ----------------SSNMRQRRTGLLT--VTERPPVI-PPEII--------REVESRMKRDYL 711
                            ::|:..:.|..||  |.:.|..| .||:.        .|...|:.|  .
Human   596 TLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLR--F 658

  Fly   712 PPTLKSLSQSPPNGTYPVGAALPMGMSKG-----LSPPHSLP-LVAAAGGSVPL 759
            |.::|..|..||..   :.|||....:..     ...|..|. |...|||..||
Human   659 PWSVKLTSSRPPEA---LMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	152/251 (61%)
		S_TKc	41..292	CDD:214567	152/250 (61%)
		UBA_SIK	335..380	CDD:270523	12/44 (27%)
MARK4	NP_001186796.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		4/6 (67%)
		STKc_MARK	58..310	CDD:270974	152/251 (61%)
		S_TKc	59..310	CDD:214567	152/250 (61%)
		UBA_MARK3_4	328..370	CDD:270590	16/75 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..614		55/342 (16%)
		MARK4_C	654..752	CDD:213382	18/61 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840