DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik3 and mark4b

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_005157655.1	Gene:	mark4b / 571279	ZFINID:	ZDB-GENE-100330-2	Length:	796	Species:	Danio rerio

Alignment Length:	738	Identity:	249/738 - (33%)
Similarity:	355/738 - (48%)	Gaps:	200/738 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRH 97
            |:...:|.|.|.|||||||||.||||.:|:|..:|||||||||.||...|.|.|||:.|:|.|.|
Zfish    50 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKGLNH 114

  Fly    98 PHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHR 162
            |:|.:|:||:|::..:|||.|||..||:||:||::|||||.||...|.|:||||||||.:.:|||
Zfish   115 PNIVQLFEVIETEKTLYLVMEYASGGEVFDYLVSHGRMKEKEARGKFRQIVSAVHYCHLKNIVHR 179

  Fly   163 DLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVV 227
            ||||||:|||.|.|||:|||||||.:..|:.|.|:||||||||||:|||.:||||:.|||||||:
Zfish   180 DLKAENLLLDADSNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVI 244

  Fly   228 LYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWL 292
            ||.||.|:|||||:.:.||:.||:.||:|:||:||.:||.::|..||:.|.:|.|::||:|.:|:
Zfish   245 LYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCEGILRRFLVLNPTKRCTLEQIMKDKWM 309

  Fly   293 S------EWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTAD 351
            :      |.:..::..|.:.|.|                       ::|  ||..|    |.:.|
Zfish   310 NVGYENDELKPYIEPVEDYNDTS-----------------------RVD--VMVGM----GYSRD 345

  Fly   352 MIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQE 416
            .|..::..|:::.|:|.|.|    |.::..:....:..:||:.:|.|.::||.|....|
Zfish   346 EIKDALTTQKYNEIFATYLL----LGRKNEDGMESRSSSSLSLARVRPSAITNGTSKHS------ 400

  Fly   417 SLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGAN 481
                    |.:::||::                       |.|:..|..:             |:
Zfish   401 --------STSSSSSTS-----------------------ASSHTKPQRS-------------AS 421

  Fly   482 T----RRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIK 542
            |    |||:                    ||     |. |:.||. :|...|....:.    .:|
Zfish   422 TYHRQRRHS--------------------DF-----CG-PSVPVA-HPKRSPTSTGEG----DLK 455

  Fly   543 DQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQ 607
            ::.|  |.....:|..|.|:.                  |.....:.||.   |||....|...:
Zfish   456 EERL--PSRKTSSSVVGSRSI------------------PPSSPMVSTAN---NPNKSEIPDRRK 497

  Fly   608 ELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTV--GCTEDLSVAHG--------- 661
            :::.......|  .......|..|.:        |.||.||::  ...|:.|::|.
Zfish   498 DINATTNNIPA--SAMTRRNTYVCTD--------RTGTDRHSLLQNGKENSSLSHRLPPASPSTH 552

  Fly   662 --SGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPN 724
              ||||:.|.  |:|...|..|...:..|             ......|::.|||     .:||
Zfish   553 SISGAGASSS--TSSERSRLTRGSTIRST-------------FHGGQLREHRPPT-----HAPP- 596

  Fly   725 GTYPVGAALPMGMSKGLSP-PHS 746
             |.|.       :|...|| |||
Zfish   597 -TSPT-------LSHEASPLPHS 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	154/251 (61%)
		S_TKc	41..292	CDD:214567	154/250 (62%)
		UBA_SIK	335..380	CDD:270523	13/44 (30%)
mark4b	XP_005157655.1	STKc_MARK	57..309	CDD:270974	154/251 (61%)
		S_TKc	58..309	CDD:214567	154/250 (62%)
		UBA_like_SF	327..369	CDD:304366	15/74 (20%)
		MARK4_C	699..796	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940