DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik3 and Gm14151

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_001091446.1	Gene:	Gm14151 / 433486	MGIID:	3651016	Length:	640	Species:	Mus musculus

Alignment Length:	788	Identity:	201/788 - (25%)
Similarity:	313/788 - (39%)	Gaps:	200/788 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLY 104
            :||:..|:|:|.|..||||.::||:|||||||:.:...|.    ....||.|:|||.||||.:|.
Mouse    23 HYEILTTLGQGTFGDVKLANHLVTQTKVAIKILPQNRKNP----LVQPEIEIMKSLDHPHIIKLL 83

  Fly   105 EVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENV 169
            .::::...|::|.|:|..||:.:.:...|.:.|.|..|:|.|||.|:.|||.:|:||||||.||:
Mouse    84 HIIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENI 148

  Fly   170 LLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCG 234
            |||...|:||.|||.......|..|.|:||:.||.|||:|:...|||..:|:||||||||.:..|
Mouse   149 LLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATG 213

  Fly   235 ALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEM 299
            .|||:|.:...:|.:::.||:...|.:|.|..::|..:|.|.|..|.|:..|.:.:||..
Mouse   214 CLPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWLKP----- 273

  Fly   300 QEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDN 364
                            ...||.:|||...:|.|  |..:|. ::.:.|.....|.:|:.|::||.
Mouse   274 ----------------DNEASPASLGENIESHP--DPSIMV-LMGVMGYNPGEIRESLREKKFDQ 319

  Fly   365 IYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANA 429
            :.|.|.:|.   ||...||:..:........|..:::..| :.:::...:..|:...|..|..|.
Mouse   320 VMATYLMLK---QQSAWENKTTKKPDPRLCDRMLRSTEPT-IKNQTAVRRASSVPTHSTFSLPNE 380

  Fly   430 SSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAH 494
            |.|            |||                              ....|..|::.|
Mouse   381 SES------------LEK------------------------------GKRTTMSHSMPP----- 398

  Fly   495 EQALANPNVPPIDFKCP---------------PQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQ 544
            .:...|....|:...||               .:.||.::
Mouse   399 TRNCFNEETTPLHSICPQLVQKAHYRRSIWGETEISDTSE------------------------- 438

  Fly   545 HLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQEL 609
                      .||.|.........:|....:.|          :..||...:.:.|:     .:.
Mouse   439 ----------ESSTGESLEHPSLKIHTLQTSMG----------VSKAGSTYSKSKGS-----SQC 478

  Fly   610 SPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTS 674
            ...:..||.:.||...|.:.|.|..|...     ..|.:.:|               |....||:
Mouse   479 VSSHHTSVEEDQCEGTNISREINPPLSPV-----SPQENLMG---------------QLHIVTTA 523

  Fly   675 SNMRQRRTGLLTVTERPPVIPPEIIRE---VESRMKRDYLPPTLK----SLSQSPPNGTYP--VG 730
            .:|....|.:.:    ||....|...|   ::.|..|...|.||:    ...|:.|...:.  |.
Mouse   524 GSMDIMNTQVTS----PPFSRKEAKGEGPAIQQRESRPSSPNTLQGHLHGRHQTAPQAPFQRRVW 584

  Fly   731 AALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRASE 795
            ..|..|:.:||.             ::....|..:|:|       ||......:.:.|  :..|.
Mouse   585 RTLRNGLIRGLR-------------TLCCCLPIEKRVH-------PTNNRDLAVSQKS--QGGSH 627

  Fly   796 GSKSQFQG 803
            |.:: |:|
Mouse   628 GIRA-FRG 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	108/251 (43%)
		S_TKc	41..292	CDD:214567	108/250 (43%)
		UBA_SIK	335..380	CDD:270523	13/44 (30%)
Gm14151	NP_001091446.1	STKc_AMPK-like	23..270	CDD:270905	108/250 (43%)
Gm14151	NP_001091446.1	UBA_MARK_Par1	290..328	CDD:270522	11/40 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810