Protein Alignment Sik3 and Gm14151

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_001091446.1
• Gene: Gm14151 / 433486
• MGIID: 3651016
• Length: 640
• Species: Mus musculus
• Alignment Length: 788
• Identity: 201/788 - (25%)
• Similarity: 313/788 - (39%)
• Gaps: 200/788 - (25%)

  Fly    40 YYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLY 104
            :||:..|:|:|.|..||||.::||:|||||||:.:...|.    ....||.|:|||.||||.:|.
Mouse    23 HYEILTTLGQGTFGDVKLANHLVTQTKVAIKILPQNRKNP----LVQPEIEIMKSLDHPHIIKLL 83

  Fly   105 EVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENV 169
            .::::...|::|.|:|..||:.:.:...|.:.|.|..|:|.|||.|:.|||.:|:||||||.||:
Mouse    84 HIIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENI 148

  Fly   170 LLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCG 234
            |||...|:||.|||.......|..|.|:||:.||.|||:|:...|||..:|:||||||||.:..|
Mouse   149 LLDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATG 213

  Fly   235 ALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEM 299
            .|||:|.:...:|.:::.||:...|.:|.|..::|..:|.|.|..|.|:..|.:.:||..
Mouse   214 CLPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWLKP----- 273

  Fly   300 QEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDN 364
                            ...||.:|||...:|.|  |..:|. ::.:.|.....|.:|:.|::||.
Mouse   274 ----------------DNEASPASLGENIESHP--DPSIMV-LMGVMGYNPGEIRESLREKKFDQ 319

  Fly   365 IYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANA 429
            :.|.|.:|.   ||...||:..:........|..:::..| :.:::...:..|:...|..|..|.
Mouse   320 VMATYLMLK---QQSAWENKTTKKPDPRLCDRMLRSTEPT-IKNQTAVRRASSVPTHSTFSLPNE 380

  Fly   430 SSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAH 494
            |.|            |||                              ....|..|::.|
Mouse   381 SES------------LEK------------------------------GKRTTMSHSMPP----- 398

  Fly   495 EQALANPNVPPIDFKCP---------------PQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQ 544
            .:...|....|:...||               .:.||.::
Mouse   399 TRNCFNEETTPLHSICPQLVQKAHYRRSIWGETEISDTSE------------------------- 438

  Fly   545 HLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQEL 609
                      .||.|.........:|....:.|          :..||...:.:.|:     .:.
Mouse   439 ----------ESSTGESLEHPSLKIHTLQTSMG----------VSKAGSTYSKSKGS-----SQC 478

  Fly   610 SPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTS 674
            ...:..||.:.||...|.:.|.|..|...     ..|.:.:|               |....||:
Mouse   479 VSSHHTSVEEDQCEGTNISREINPPLSPV-----SPQENLMG---------------QLHIVTTA 523

  Fly   675 SNMRQRRTGLLTVTERPPVIPPEIIRE---VESRMKRDYLPPTLK----SLSQSPPNGTYP--VG 730
            .:|....|.:.:    ||....|...|   ::.|..|...|.||:    ...|:.|...:.  |.
Mouse   524 GSMDIMNTQVTS----PPFSRKEAKGEGPAIQQRESRPSSPNTLQGHLHGRHQTAPQAPFQRRVW 584

  Fly   731 AALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRASE 795
            ..|..|:.:||.             ::....|..:|:|       ||......:.:.|  :..|.
Mouse   585 RTLRNGLIRGLR-------------TLCCCLPIEKRVH-------PTNNRDLAVSQKS--QGGSH 627

  Fly   796 GSKSQFQG 803
            |.:: |:|
Mouse   628 GIRA-FRG 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	108/251 (43%)
		UBA_SIK	335..380	CDD:270523	13/44 (30%)
Gm14151	NP_001091446.1	STKc_AMPK-like	23..270	CDD:270905	108/250 (43%)
		UBA_MARK_Par1	290..328	CDD:270522	11/40 (28%)