DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik3 and CG14305

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_650732.1	Gene:	CG14305 / 42233	FlyBaseID:	FBgn0038630	Length:	302	Species:	Drosophila melanogaster

Alignment Length:	284	Identity:	93/284 - (32%)
Similarity:	154/284 - (54%)	Gaps:	25/284 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTK---------TKVAIKIIDKTCLNEEYL 82
            |....||.|.:.| |.:...||:|::|.|      :|.         ..:|.|||||.....:::
  Fly    15 TRSSDVDALAQRG-YNVGHKIGEGSYATV------ITAGYADDHGHGVHLACKIIDKAKAPTDFV 72

  Fly    83 NKTF-REIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQ 146
            ||.| ||:.||..:.|.:|.:::.:::....|::...||.||::..|:..:|.:.|.::...|.|
  Fly    73 NKFFPRELEILTKIDHSNIIQIHSILQRGPKIFIFMRYAENGDLLSHIKRSGPIDEKQSKIWFFQ 137

  Fly   147 LVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHY--EEGATLK--TWCGSPPYAAPE 207
            :..|:.|.|...:.|||||.||:||.|.:|||||||||:.:.  :.|..:|  |:|||..|||||
  Fly   138 MSKALKYLHNLDIAHRDLKCENILLSKRLNIKLADFGFARYCRDDNGREMKSETYCGSAAYAAPE 202

  Fly   208 VFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILEL----KSRVVLGKFRIPFFMSQECEQL 268
            |..|..||...:|.|||||:|:.::...:|||...:.:|    ::|....:.::...:|.:.:..
  Fly   203 VVCGRPYDPKLADAWSLGVILFIMMNAKMPFDDSNLTKLLEDQRNRKFAFRRKLQETISAQAKAT 267

  Fly   269 IRNMLVVEPDRRYTIKQIIKHRWL 292
            :..:|..|...|:.:::|:...||
  Fly   268 VSVLLEPEAHARWNLREILNCAWL 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	86/269 (32%)
		S_TKc	41..292	CDD:214567	86/268 (32%)
		UBA_SIK	335..380	CDD:270523
CG14305	NP_650732.1	STKc_TSSK-like	27..291	CDD:270982	87/270 (32%)
CG14305	NP_650732.1	S_TKc	28..287	CDD:214567	86/264 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010